Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Francis X. Witkowski"'
Autor:
Anders Nygren, Robert B. Clark, Colleen S. Kondo, Francis X. Witkowski, Darrell D. Belke, Wayne R. Giles
Publikováno v:
Annals of Biomedical Engineering. 28:958-967
A custom-made apparatus based on a charge-coupled-device camera has been used to monitor changes in fluorescence from Langendorff-perfused adult mouse hearts stained with a voltage-sensitive dye, di-4-ANEPPS. With this approach it is possible to moni
Autor:
Jeffrey E. Saffitz, Bodh I. Jugdutt, Francis X. Witkowski, Patricia A. Guerrero, Katherine M. Kavanagh
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 77:510-519
This study tests the hypothesis that moderate myocardial dysfunction is associated with altered myocardial anisotropic properties and structurally altered ventricular fibrillation (VF). Mongrel dogs were randomized to either a control group or a grou
Autor:
William L. Ditto, L. Joshua Leon, Wayne R. Giles, Robert B. Clark, Patricia A. Penkoske, Francis X. Witkowski, Mark L. Spano
Publikováno v:
Chaos: An Interdisciplinary Journal of Nonlinear Science. 8:94-102
The measurement of cardiac transmembrane potential changes with voltage sensitive dyes is in increasing use. Detection of these very small fluorescent alterations using large multiplexed arrays, such as charge coupled device (CCD) cameras at high sam
Autor:
Francis X. Witkowski, L. Joshua Leon
Publikováno v:
Journal of Cardiovascular Electrophysiology. 6:379-390
Transmembrane Current Estimation. Introduction: A mathematical/computer model of cardiac tissue was used to study the estimation of transmembrane current (EIm) from extracellular potential recordings. Methods and Results: The simulated EIm of transme
Publikováno v:
Journal of Cardiovascular Electrophysiology. 2:562-572
Mechanisms of Cardiac Defibrillation. Cardiac defibrillation is currently the only available successful therapy for ventricular fibrillation. Despite the wide application of this effective clinical tool, controversy exists concerning the electrophysi
Publikováno v:
Journal of Surgical Research. 49:337-340
Many physiological investigations of cardiac function require accurate control of heart rate. To examine heart rate effects at values lower than the intrinsic heart rate requires the ability to prevent an accelerated junctional rhythm from becoming d
Autor:
David E. Johnstone, Ross B. MacKenzie, Robert M. Miller, Bohumil M. Horacek, Cynthia A. Spencer, Francis X. Witkowski, Terrence J. Montague
Publikováno v:
Chest. 97:1333-1342
Body surface ST integral maps were recorded in 36 coronary artery disease (CAD) patients at: rest; peak, angina-limited exercise; and, 1 and 5 min of recovery. They were compared to maps of 15 CAD patients who exercised to fatigue, without angina, an
Publikováno v:
Journal of Electrocardiology. 23:39-45
The widespread clinical application of implantable electrical defibrillation devices has engendered considerable interest into the mechanism of action of such devices. In addition, better means of rapid detection of postshock efficacy have been sough
Publikováno v:
Proceedings of the 15th Annual International Conference of the IEEE Engineering in Medicine and Biology Societ.
Autor:
P.A. Penkoske, Francis X. Witkowski
Publikováno v:
[1990] Proceedings of the Twelfth Annual International Conference of the IEEE Engineering in Medicine and Biology Society.
In vivo intracellular cardiac recordings using conventional glass microelectrodes to study the mechanisms of action of defibrillatory shocks are limited by electrode fragility. A technique was devised using sintered Ag/AgCl electrodes that allows mul