Zobrazeno 1 - 10
of 267
pro vyhledávání: '"Francis SH"'
Autor:
Matthew Franklin, Francis Shupo, Grace Wayi-Wayi, Natasa Zibelnik, Emily Jones, Nicola Mason, John Brazier, Sudipto Mukherjee
Publikováno v:
Oncology and Therapy, Vol 12, Iss 3, Pp 491-508 (2024)
Abstract Introduction Idiopathic multicentric Castleman disease (iMCD) is a rare, chronic, debilitating lymphoproliferative disorder where the mainstay of treatment is symptom management. Our recent international patient survey showed that patients w
Externí odkaz:
https://doaj.org/article/2e1b76a676c34735bda2a0626d7a24ce
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-22 (2023)
Abstract Vascular cognitive impairment and dementia (VCID) is commonly caused by vascular injuries in cerebral large and small vessels and is a key driver of age-related cognitive decline. Severe VCID includes post-stroke dementia, subcortical ischem
Externí odkaz:
https://doaj.org/article/727f856306844f23b2203646878b13e9
Autor:
Wenhui Qiao, Yixing Chen, Jun Zhong, Benjamin J. Madden, Cristine M. Charlesworth, Yuka A. Martens, Chia-Chen Liu, Joshua Knight, Tadafumi C. Ikezu, Aishe Kurti, Yiyang Zhu, Axel Meneses, Cassandra L. Rosenberg, Lindsey A. Kuchenbecker, Lucy K. Vanmaele, Fuyao Li, Kai Chen, Francis Shue, Maxwell V. Dacquel, John Fryer, Akhilesh Pandey, Na Zhao, Guojun Bu
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-22 (2023)
Abstract Background The rare p.H157Y variant of TREM2 (Triggering Receptor Expressed on Myeloid Cells 2) was found to increase Alzheimer’s disease (AD) risk. This mutation is located at the cleavage site of TREM2 extracellular domain. Ectopic expre
Externí odkaz:
https://doaj.org/article/aeb26e05f9954b82bf1169b444687ab2
Autor:
Na Wang, Minghui Wang, Suren Jeevaratnam, Cassandra Rosenberg, Tadafumi C. Ikezu, Francis Shue, Sydney V. Doss, Alla Alnobani, Yuka A. Martens, Melissa Wren, Yan W. Asmann, Bin Zhang, Guojun Bu, Chia-Chen Liu
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-20 (2022)
Abstract Background Abnormal lipid accumulation has been recognized as a key element of immune dysregulation in microglia whose dysfunction contributes to neurodegenerative diseases. Microglia play essential roles in the clearance of lipid-rich cellu
Externí odkaz:
https://doaj.org/article/c84dad3190d44dd7b5898869d241cadf
Autor:
Sudipto Mukherjee, Francis Shupo, Grace Wayi-Wayi, Natasa Zibelnik, Emily Jones, Nicola Mason, Matthew Franklin, John Brazier
Publikováno v:
EClinicalMedicine, Vol 64, Iss , Pp 102192- (2023)
Summary: Background: Idiopathic Multicentric Castleman Disease (iMCD) is a rare inflammatory lymphoproliferative disorder with heterogenous clinical presentations. The symptomatology in iMCD patients remains poorly understood. The aim of this study w
Externí odkaz:
https://doaj.org/article/f60a4f73ab904812b44261352373f2a9
Autor:
Matt Franklin, Francis Shupo, Emily Jones, Nicola Mason, Grace Wayi-Wayi, Karan Kanhai, Natasa Zibelnick, Mileva Repasky, Kelly Makarounas-Kirchmann, Sudipto Mukherjee, John Brazier
Publikováno v:
HemaSphere, Vol 7, p e69432f9 (2023)
Externí odkaz:
https://doaj.org/article/20c8c50023504171b35f1e6c71d49a27
Autor:
Hiroshi Oue, Yu Yamazaki, Wenhui Qiao, Chen Yuanxin, Yingxue Ren, Aishe Kurti, Francis Shue, Tammee M. Parsons, Ralph B. Perkerson, Keiji Kawatani, Ni Wang, Skylar C. Starling, Bhaskar Roy, Ioana-Emilia Mosneag, Tomonori Aikawa, Marie-Louise Holm, Chia-Chen Liu, Yasuteru Inoue, Patrick M. Sullivan, Yan W. Asmann, Betty Y.S. Kim, Guojun Bu, Takahisa Kanekiyo
Publikováno v:
JCI Insight, Vol 8, Iss 7 (2023)
Cerebrovasculature is critical in maintaining brain homeostasis; its dysregulation often leads to vascular cognitive impairment and dementia (VCID) during aging. VCID is the second most prevalent cause of dementia in the elderly, after Alzheimer’s
Externí odkaz:
https://doaj.org/article/3982980e6d7948619fd5c5933bf5242e
Autor:
Amer N. Kadri, MD, George Hanzel, MD, Sammy Elmariah, MD, Francis Shannon, MD, Karim Al-Azizi, MD, Judith Boura, MS, Michael Mack, MD, Amr E. Abbas, MD
Publikováno v:
JTCVS Open, Vol 7, Iss , Pp 51-60 (2021)
Objectives: To compare echocardiographic and invasive mean gradients obtained concomitantly in degenerated bioprosthetic surgical aortic valves (SAVRs). Methods: In a multicenter study, we compared concomitant echocardiographic and invasive mean grad
Externí odkaz:
https://doaj.org/article/38e657cf56244b43bdf389869bccfd52
Publikováno v:
Asian Journal of Medical Sciences, Vol 12, Iss 8, Pp 149-154 (2021)
Background: Interpretation of body mass index in children is quite different from that in adults which use standard weight status categories that are the same for all ages and for both men and women. Aims and Objective: The study was aimed at dete
Externí odkaz:
https://doaj.org/article/bd05093ba85f4b6f89d6e4b864397411
Autor:
Jing Zhao, Yuan Fu, Yu Yamazaki, Yingxue Ren, Mary D. Davis, Chia-Chen Liu, Wenyan Lu, Xue Wang, Kai Chen, Yesesri Cherukuri, Lin Jia, Yuka A. Martens, Lucy Job, Francis Shue, Thanh Thanh Nguyen, Steven G. Younkin, Neill R. Graff-Radford, Zbigniew K. Wszolek, David A. Brafman, Yan W. Asmann, Nilüfer Ertekin-Taner, Takahisa Kanekiyo, Guojun Bu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
APOE4 is a strong genetic risk factor for late-onset Alzheimer’s disease. Here, the authors show that APOE4 is associated with AD features in hiPSCs-derived cerebral organoids. Isogenic conversion of APOE4 to APOE3 attenuates the AD-associated phen
Externí odkaz:
https://doaj.org/article/6279c67f0fd74c15a58ff8bbebdd96ab