Zobrazeno 1 - 10
of 137
pro vyhledávání: '"Francis S, Markland"'
Autor:
Steve Swenson, Radu O. Minea, Cao Duc Tuan, Thu-Zan Thein, Thomas C. Chen, Francis S. Markland
Publikováno v:
Molecules, Vol 23, Iss 11, p 2918 (2018)
We developed a bacterial expression system to produce a recombinant disintegrin, vicrostatin (VCN), whose structure is based on a natural disintegrin isolated from southern copperhead snake venom. Our goal is to develop VCN for potential clinical tra
Externí odkaz:
https://doaj.org/article/0500811d701f4fb1977ce3622aa02ba3
Autor:
Radu O Minea, Corey M Helchowski, Samuel J Zidovetzki, Fritz K Costa, Stephen D Swenson, Francis S Markland
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e10929 (2010)
Similar to other integrin-targeting strategies, disintegrins have previously shown good efficacy in animal cancer models with favorable pharmacological attributes and translational potential. Nonetheless, these polypeptides are notoriously difficult
Externí odkaz:
https://doaj.org/article/14648aebbdc544c5988dfa92d26ec79e
Autor:
Ryan Park, Steve Swenson, Li-Peng Yap, Francis S. Markland, Hossein Jadvar, Ivetta Vorobyova, Kai Chen
Publikováno v:
Amino Acids
A novel recombinant disintegrin, vicrostatin (VCN), displays high binding affinity to a broad range of human integrins in substantial competitive biological advantage over other integrin-based antagonists. In this study, we synthesized a new (64)Cu-l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a970c33a868b383a37569faf56414599
https://europepmc.org/articles/PMC6881555/
https://europepmc.org/articles/PMC6881555/
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2068
Integrin targeting has been shown to be an effective approach for anticancer therapy. We engineered a recombinant disintegrin, vicrostatin (VCN), that binds with high affinity and specificity to the Arg-Gly-Asp (RGD) class of integrins, including αv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9060083da82e859c8f022efdf8875980
https://pubmed.ncbi.nlm.nih.gov/31576529
https://pubmed.ncbi.nlm.nih.gov/31576529
Publikováno v:
Snake and Spider Toxins ISBN: 9781493998449
Integrin targeting has been shown to be an effective approach for anticancer therapy. We engineered a recombinant disintegrin, vicrostatin (VCN), that binds with high affinity and specificity to the Arg-Gly-Asp (RGD) class of integrins, including αv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c270881b618213680b2cfc43052b36e0
https://doi.org/10.1007/978-1-4939-9845-6_10
https://doi.org/10.1007/978-1-4939-9845-6_10
Publikováno v:
Cancer Research. 81:PO030-PO030
Disintegrins are disulfide-rich peptides, many containing an Arg-Gly-Asp (RGD) motif. They hold significant translational potential as anti-cancer agents based on their high-affinity/high-specificity interaction with tumor integrins and desirable pha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e402d4d619d5c3b53d6c17d0128f610c
https://doi.org/10.1158/1538-7445.tme21-po030
https://doi.org/10.1158/1538-7445.tme21-po030
Publikováno v:
Biochemical Pharmacology. 181:114149
Snake venoms consist of a complex mixture of many bioactive molecules. Among them are disintegrins, which are peptides without enzymatic activity, but with high binding affinity for integrins, transmembrane receptors that function to connect cells wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11993c12e25f386d66d12cc304ac6717
https://doi.org/10.1016/j.bcp.2020.114149
https://doi.org/10.1016/j.bcp.2020.114149
Autor:
Thomas C. Chen, Francis S. Markland, Cao Duc Tuan, Thu-Zan Thein, Radu O. Minea, Steve Swenson
Publikováno v:
Molecules, Vol 23, Iss 11, p 2918 (2018)
Molecules
Volume 23
Issue 11
Molecules
Volume 23
Issue 11
We developed a bacterial expression system to produce a recombinant disintegrin, vicrostatin (VCN), whose structure is based on a natural disintegrin isolated from southern copperhead snake venom. Our goal is to develop VCN for potential clinical tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f2075b42d9506657b9ead4ad9a57eec
https://www.mdpi.com/1420-3049/23/11/2918
https://www.mdpi.com/1420-3049/23/11/2918
Autor:
Honggang Cui, Francis S. Markland, Martha K. Pastuszka, Stephen Swenson, J. Andrew MacKay, Siti M. Janib, Peter S. Conti, Radu O. Minea, Lye Lin Lock, Zibo Li, Joshua A. Gustafson, Shuanglong Liu
Publikováno v:
Biomacromolecules
Recombinant protein therapeutics have increased in number and frequency since the introduction of human insulin, 25 years ago. Presently, proteins and peptides are commonly used in the clinic. However, the incorporation of peptides into clinically ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d336bb227eb87536f71c084b9eb6ac4
http://europepmc.org/articles/PMC4098058
http://europepmc.org/articles/PMC4098058
Autor:
Francis S. Markland, Stephen Swenson
Publikováno v:
Toxicon. 62:3-18
Recent proteomic analyses of snake venoms show that metalloproteinases represent major components in most of the Crotalid and Viperid venoms. In this chapter we discuss the multiple activities of the SVMPs. In addition to hemorrhagic activity, member
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54b66df7a61b4e4942e4380685ca5c82
https://doi.org/10.1016/j.toxicon.2012.09.004
https://doi.org/10.1016/j.toxicon.2012.09.004