Zobrazeno 1 - 10
of 5 311
pro vyhledávání: '"Francis Robert"'
Autor:
Inci S. Aksoylu, Pauline Martin, Francis Robert, Krzysztof J. Szkop, Nicholas E. Redmond, Srirupa Bhattacharyya, Jennifer Wang, Shan Chen, Roberta L. Beauchamp, Irene Nobeli, Jerry Pelletier, Ola Larsson, Vijaya Ramesh
Publikováno v:
Molecular Autism, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Background Tuberous sclerosis complex (TSC) is an inherited neurocutaneous disorder caused by mutations in the TSC1 or TSC2 genes, with patients often exhibiting neurodevelopmental (ND) manifestations termed TSC-associated neuropsychiatric d
Externí odkaz:
https://doaj.org/article/057c7629fc914290bfd51a7dc5438070
Autor:
Leo Shen, Lauren Pugsley, Regina Cencic, HanChen Wang, Francis Robert, Sai Kiran Naineni, Ananya Sahni, Geneviève Morin, Wenhan Zhang, Anastasia Nijnik, John A. Porco, David Langlais, Sidong Huang, Jerry Pelletier
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Rocaglates are a class of eukaryotic translation initiation inhibitors that are being explored as chemotherapeutic agents. They function by targeting eukaryotic initiation factor (eIF) 4A, an RNA helicase critical for recruitment of the 40S
Externí odkaz:
https://doaj.org/article/8c4f9a7786f645b480c54ec87a7139b4
Autor:
Karina Chan, Francis Robert, Christian Oertlin, Dana Kapeller-Libermann, Daina Avizonis, Johana Gutierrez, Abram Handly-Santana, Mikhail Doubrovin, Julia Park, Christina Schoepfer, Brandon Da Silva, Melissa Yao, Faith Gorton, Junwei Shi, Craig J. Thomas, Lauren E. Brown, John A. Porco, Michael Pollak, Ola Larsson, Jerry Pelletier, Iok In Christine Chio
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Metabolic reprogramming is a hallmark of pancreatic ductal adenocarcinoma (PDA). Here, the authors show that in PDA cells redox and central carbon metabolism are driven by an eIF4F dependent translation program, and combined targeting of eIF4A and gl
Externí odkaz:
https://doaj.org/article/5805d19b9df44bceaf4b4ac6e534ad64
Autor:
Jennifer Chu, Wenhan Zhang, Regina Cencic, Patrick B.F. O’Connor, Francis Robert, William G. Devine, Asher Selznick, Thomas Henkel, William C. Merrick, Lauren E. Brown, Pavel V. Baranov, John A. Porco, Jr., Jerry Pelletier
Publikováno v:
Cell Reports, Vol 30, Iss 8, Pp 2481-2488.e5 (2020)
Summary: Rocaglates are a diverse family of biologically active molecules that have gained tremendous interest in recent years due to their promising activities in pre-clinical cancer studies. As a result, this family of compounds has been significan
Externí odkaz:
https://doaj.org/article/21a67c621b25477f8f89045cf022ad46
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 8, Iss 5, Pp 1627-1635 (2018)
Genetically engineered mouse models (GEMMs) are powerful tools by which to probe gene function in vivo, obtain insight into disease etiology, and identify modifiers of drug response. Increased sophistication of GEMMs has led to the design of tissue-s
Externí odkaz:
https://doaj.org/article/56c199e4afd447a19de5356776ec478e
Autor:
Sanaz Manteghi, Marie-Claude Gingras, Dmitri Kharitidi, Luc Galarneau, Maud Marques, Ming Yan, Regina Cencic, Francis Robert, Marilène Paquet, Michael Witcher, Jerry Pelletier, Arnim Pause
Publikováno v:
Cell Reports, Vol 15, Iss 9, Pp 1893-1900 (2016)
Endosomal sorting complexes required for transport (ESCRT) drive cell surface receptor degradation resulting in attenuation of oncogenic signaling and pointing to a tumor suppressor function. Here, we show that loss of function of an ESCRT protein (H
Externí odkaz:
https://doaj.org/article/20c7418fb9944e4c9e74f85af9af9e62
Autor:
Francis Robert, Jerry Pelletier
Publikováno v:
Frontiers in Genetics, Vol 9 (2018)
Over the past 15 years, sequencing of the human genome and The Cancer Genome Atlas (TCGA) project have led to comprehensive lists of single-nucleotide polymorphisms (SNPs) and gene mutations across a large number of human samples. However, our abilit
Externí odkaz:
https://doaj.org/article/66efc488696d43e8b30285e616e48e97
Autor:
Frédéric Picard-Jean, Carolin Brand, Maude Tremblay-Létourneau, Andréa Allaire, Maxime C Beaudoin, Simon Boudreault, Cyntia Duval, Julien Rainville-Sirois, Francis Robert, Jerry Pelletier, Brian J Geiss, Martin Bisaillon
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0193804 (2018)
The 5' RNA cap structure (m7GpppRNA) is a key feature of eukaryotic mRNAs with important roles in stability, splicing, polyadenylation, mRNA export, and translation. Higher eukaryotes can further modify this minimal cap structure with the addition of
Externí odkaz:
https://doaj.org/article/ef263c70fce2423fbcaa628572258e52