Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Francis P. Pankowicz"'
Autor:
Mercedes Barzi, Tong Chen, Trevor J. Gonzalez, Francis P. Pankowicz, Seh Hoon Oh, Helen L. Streff, Alan Rosales, Yunhan Ma, Sabrina Collias, Sarah E. Woodfield, Anna Mae Diehl, Sanjeev A. Vasudevan, Thao N. Galvan, John Goss, Charles A. Gersbach, Beatrice Bissig-Choisat, Aravind Asokan, Karl-Dimiter Bissig
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Clinical translation of AAV-mediated gene therapy requires preclinical development across different experimental models, often confounded by variable transduction efficiency. Here, we describe a human liver chimeric transgene-free Il2rg −/
Externí odkaz:
https://doaj.org/article/3464bdb424c442108002dbd891da2d8d
Autor:
Robert L. Kruse, Mercedes Barzi, Xavier Legras, Francis P. Pankowicz, Nika Furey, Lan Liao, Janming Xu, Beatrice Bissig-Choisat, Betty L. Slagle, Karl-Dimiter Bissig
Publikováno v:
JHEP Reports, Vol 3, Iss 2, Pp 100252- (2021)
Background & Aims: Development of new and more effective therapies against hepatitis B virus (HBV) is limited by the lack of suitable small animal models. The HBV transgenic mouse model containing an integrated overlength 1.3-mer construct has yielde
Externí odkaz:
https://doaj.org/article/3ed29fbe45da41f499709b7abe8d5061
Autor:
Mercedes Barzi, Francis P. Pankowicz, Barry Zorman, Xing Liu, Xavier Legras, Diane Yang, Malgorzata Borowiak, Beatrice Bissig-Choisat, Pavel Sumazin, Feng Li, Karl-Dimiter Bissig
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Human liver chimeric mice are increasingly used for drug testing in preclinical development, but express residual murine p450 cytochromes. Here the authors generate mice lacking the Por gene in the liver, and show that human cytochrome metabolism is
Externí odkaz:
https://doaj.org/article/3e218892915b40fa9da11819b0704336
Autor:
Francis P. Pankowicz, Mercedes Barzi, Xavier Legras, Leroy Hubert, Tian Mi, Julie A. Tomolonis, Milan Ravishankar, Qin Sun, Diane Yang, Malgorzata Borowiak, Pavel Sumazin, Sarah H. Elsea, Beatrice Bissig-Choisat, Karl-Dimiter Bissig
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-6 (2016)
Hereditary tyrosinaemia type I is caused by a gene defect that leads to a lethal accumulation of toxic metabolites in the liver. Here the authors use CRISPR/Cas9 to 'cure' the disease in mice by inactivating another gene, rather than targeting the di
Externí odkaz:
https://doaj.org/article/c9a870f56fb24cb1bba81c0bca196a4d
Autor:
Mercedes Barzi, Francis P. Pankowicz, Barry Zorman, Xing Liu, Xavier Legras, Diane Yang, Malgorzata Borowiak, Beatrice Bissig-Choisat, Pavel Sumazin, Feng Li, Karl-Dimiter Bissig
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-1 (2017)
An incorrect version of the Supplementary Information was inadvertently published with this Article where the wrong file was included. The HTML has been updated to include the correct version of the Supplementary Information.
Externí odkaz:
https://doaj.org/article/e4c3baa00a464fb7be24791025631cf9
P450-Humanized and Human Liver Chimeric Mouse Models for Studying Xenobiotic Metabolism and Toxicity
Autor:
Karl-Dimiter Bissig, Francis P. Pankowicz, Liang Ding, Xinxin Ding, Nataliia Kovalchuk, Qing Yu Zhang, Mercedes Barzi, Weiguo Han, Xiaoyu Fan
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 46(11)
Preclinical evaluation of drug candidates in experimental animal models is an essential step in drug development. Humanized mouse models have emerged as a promising alternative to traditional animal models. The purpose of this mini-review is to provi
Autor:
Juan C. Marini, Xavier Legras, Sarah H. Elsea, Francis P. Pankowicz, Beatrice Bissig-Choisat, David D. Moore, Karl-Dimiter Bissig, Celeste Santos Martins, William R. Lagor, Clavia Ruth Wooton-Kee, Kang Ho Kim, Mercedes Barzi
Publikováno v:
Gastroenterology. 155(6)
Background & aims Despite advances in gene editing technologies, generation of tissue-specific knockout mice is time-consuming. We used CRISPR/Cas9-mediated genome editing to disrupt genes in livers of adult mice in just a few months, which we refer
Autor:
Malgorzata Borowiak, Francis P. Pankowicz, Diane Yang, Pavel Sumazin, Mercedes Barzi, Barry Zorman, Xing Liu, Beatrice Bissig-Choisat, Xavier Legras, Karl-Dimiter Bissig, Feng Li
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Only one out of 10 drugs in development passes clinical trials. Many fail because experimental animal models poorly predict human xenobiotic metabolism. Human liver chimeric mice are a step forward in this regard, as the human hepatocytes in chimeric
Publikováno v:
Gut. 66(7)
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 genome engineering has revolutionised biomedical science and we are standing on the cusp of medical transformation. The therapeutic potential of this technology is tremendous, ho
Autor:
Diane Yang, Beatrice Bissig-Choisat, Milan Ravishankar, Qin Sun, Sarah H. Elsea, Pavel Sumazin, Karl-Dimiter Bissig, Tian Mi, Francis P. Pankowicz, Mercedes Barzi, Malgorzata Borowiak, Julie A. Tomolonis, Leroy Hubert, Xavier Legras
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-6 (2016)
Nature Communications
Nature Communications
Many metabolic liver disorders are refractory to drug therapy and require orthotopic liver transplantation. Here we demonstrate a new strategy, which we call metabolic pathway reprogramming, to treat hereditary tyrosinaemia type I in mice; rather tha