Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Francis P. McManus"'
Autor:
Chongyang Li, Francis P. McManus, Cédric Plutoni, Cristina Mirela Pascariu, Trent Nelson, Lara Elis Alberici Delsin, Gregory Emery, Pierre Thibault
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
PIAS1 is an E3 SUMO ligase involved in various cellular processes. Here, the authors use quantitative proteomics to identify potential PIAS1 substrates in human cells and elucidate the biological consequences of PIAS1-mediated SUMOylation of vimentin
Externí odkaz:
https://doaj.org/article/ac44f97edfdb415aac4d3879661d3d3c
Autor:
Frédéric Lamoliatte, Francis P. McManus, Ghizlane Maarifi, Mounira K. Chelbi-Alix, Pierre Thibault
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Ubiquitylation and SUMOylation are two important related post-translational modifications. Here the authors present an approach for the simultaneous identification and quantification of protein-wide SUMO and ubiquitin sites from a single sample, unco
Externí odkaz:
https://doaj.org/article/b154cff5cc4243dfbe1fb2ed128260a0
Autor:
Nadia M. Schoonhoven, Derek K. O’Flaherty, Francis P. McManus, Lauralicia Sacre, Anne M. Noronha, M. Judith Kornblatt, Christopher J. Wilds
Publikováno v:
Molecules, Vol 22, Iss 11, p 1948 (2017)
O6-Alkylguanine-DNA alkyltransferases (AGTs) are proteins responsible for the removal of mutagenic alkyl adducts at the O6-atom of guanine and O4-atom of thymine. In the current study we set out to understand the role of the Ser134 residue in the Esc
Externí odkaz:
https://doaj.org/article/57129a90d2c542cfa3f6394bf5b13f07
Autor:
Jian Qin, Francis P. McManus, Deanna Elise MacNeil, Chantal Autexier, Pierre Thibault, Eric Bonneil, Patrick Lambert-Lanteigne
Publikováno v:
Mol Cell Biol
The nuclear and subnuclear compartmentalization of the telomerase-associated protein and H/ACA ribonucleoprotein component dyskerin is an important although incompletely understood aspect of H/ACA ribonucleoprotein function. Four SUMOylation sites we
Autor:
Francis P. McManus, Derek J. Bailey, Sibylle Pfammatter, Eric Bonneil, Pierre Thibault, Satendra Prasad, Michael W. Belford, Jean-Jacques Dunyach
Publikováno v:
Molecular & Cellular Proteomics. 17:2051-2067
The depth of proteomic analyses is often limited by the overwhelming proportion of confounding background ions that compromise the identification and quantification of low abundance peptides. To alleviate these limitations, we present a new high fiel
Publikováno v:
Cytokine and Growth Factor Reviews
Cytokine and Growth Factor Reviews, Elsevier, 2020, 55, pp.37-47. ⟨10.1016/j.cytogfr.2020.03.001⟩
Cytokine and Growth Factor Reviews, 2020, 55, pp.37-47. ⟨10.1016/j.cytogfr.2020.03.001⟩
Cytokine and Growth Factor Reviews, Elsevier, 2020, 55, pp.37-47. ⟨10.1016/j.cytogfr.2020.03.001⟩
Cytokine and Growth Factor Reviews, 2020, 55, pp.37-47. ⟨10.1016/j.cytogfr.2020.03.001⟩
International audience; SUMOylation is a reversible post-translational modification that regulates several cellular processes including protein stability, subcellular localization, protein–protein interactions and plays a key role in the interferon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2889bc20758571fe99eed1ccb4f7585e
https://hal.archives-ouvertes.fr/hal-03493273
https://hal.archives-ouvertes.fr/hal-03493273
Autor:
Eric Bonneil, Jian Qin, Patrick Lambert-Lanteigne, Francis P. McManus, Pierre Thibault, Chantal Autexier, Deanna Elise MacNeil
SummaryDyskerin, a telomerase-associated protein and H/ACA ribonucleoprotein complex component plays an essential role in human telomerase assembly and activity. The nuclear and subnuclear compartmentalization of dyskerin and the H/ACA complex is an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc5f266ea808c57bca190ff010705d50
https://doi.org/10.1101/2020.09.02.280198
https://doi.org/10.1101/2020.09.02.280198
Autor:
Francis P. McManus, Pierre Thibault, Neelam Shahani, Sophia Louise Lucille Park, Srinivasa Subramaniam, Manish Sharma, Uri Nimrod Ramírez-Jarquín, Oscar Rivera
The mechanistic target of rapamycin (mTOR) signaling is influenced by multiple regulatory proteins and post-translational modifications, however, underlying mechanisms remains unclear. Here, we report a novel role of small ubiquitin-like modifier (SU
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::382e5e28984b9085bda43eab50674e11
https://doi.org/10.1101/2020.09.03.281881
https://doi.org/10.1101/2020.09.03.281881
Autor:
Thibault Pierre, Srinivasa Subramaniam, Neelam Shahani, Pabalu Karunadharma, Uri Nimrod Ramírez-Jarquín, Francis P. McManus, Manish Sharma, Gogce Crynen, Oscar Rivera
Rhes (Ras homolog enriched in the striatum) is a multifunctional protein that orchestrates striatal toxicity, motor behaviors and abnormal movements associated with dopaminergic signaling, Huntington disease and Parkinson disease signaling in the str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c3d51020420805005d277ff3c97abf6
https://doi.org/10.1101/2020.06.18.160044
https://doi.org/10.1101/2020.06.18.160044
Publikováno v:
Journal of proteome research. 19(5)
Arsenic trioxide (ATO) is a therapeutic agent used to treat acute promyelocytic leukemia (APL), a disease caused by a chromosomal translocation of the retinoic acid receptor α (RARα) gene that can occur reciprocally with the promyelocytic leukemia