Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Francis P. Arena"'
Autor:
Patrick J. Magill, Elizabeth Anderson, Elsa M. Cora, Sarah Bacus, Claire Watkins, Elizabeth Curcio, Joan F. Kroener, Francis P. Arena, Ian Rabinowitz, Melanie Royce, Aroop Mangalik, Vicente Valero, Massimo Cristofanilli
Purpose: This phase II randomized trial evaluated the efficacy and tolerability of anastrozole combined with gefitinib or anastrozole with placebo in women with hormone receptor–positive metastatic breast cancer (MBC).Experimental Design: Postmenop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04eef7a44323438f83c0b2e5c9a2110a
https://doi.org/10.1158/1078-0432.c.6517791
https://doi.org/10.1158/1078-0432.c.6517791
Autor:
Patrick J. Magill, Elizabeth Anderson, Elsa M. Cora, Sarah Bacus, Claire Watkins, Elizabeth Curcio, Joan F. Kroener, Francis P. Arena, Ian Rabinowitz, Melanie Royce, Aroop Mangalik, Vicente Valero, Massimo Cristofanilli
Supplementary Data from Phase II, Randomized Trial to Compare Anastrozole Combined with Gefitinib or Placebo in Postmenopausal Women with Hormone Receptor–Positive Metastatic Breast Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27a396e499ae23400b6df0c1f280f3c2
https://doi.org/10.1158/1078-0432.22440465.v1
https://doi.org/10.1158/1078-0432.22440465.v1
Critical Aspects of a Sustainable Clinical Research Program in the Community-Based Oncology Practice
Publikováno v:
American Society of Clinical Oncology Educational Book. :176-184
Increasing enrollment into clinical trials is a top priority across the field of oncology. Because the vast majority of those afflicted with cancer receive their care in the community, creating strong clinical research programs in the community-based
Publikováno v:
Current Treatment Options in Gastroenterology. 14:507-534
As new and effective novel therapies in inflammatory bowel disease (IBD) become available, patients are living longer with advancing age and are at increased risk for malignancy. The management of IBD and malignancy involves multiple combinations of
Autor:
Tetiana Taran, Y-S Yap, Anne C Armstrong, Francis P. Arena, Mustafa Ozguroglu, B H Xu, Kunwei Shen, Claudine Isaacs, Zsuzsanna Papai, Ruth O'Regan, Guillermo Lerzo, L B Pacaud, A Jappe, István Láng, Noriyuki Masuda, Michelle White, Yunyu Zhang
Publikováno v:
Cancer Research. 76:P4-13
Background PI3K/AKT/mTOR pathway activation due to PTEN loss may lead to trastuzumab (TRAS) resistance. mTOR inhibition has been shown to restore TRAS sensitivity in PTEN-deficient tumors. This provided the rationale for the BOLERO-3 trial which eval
Autor:
Michael M. Chen, Edward H. Kaplan, Luis H. Camacho, Bryan J. Bienvenu, Mary Tagliaferri, Luis T. Campos, Dapeng Li, J. Paul Waymack, Lee S. Schwartzberg, Francis P. Arena
Publikováno v:
Journal of Cancer
Background: This study was designed to assess the safety and preliminary efficacy of KLTi plus gemcitabine in patients with locally advanced or metastatic pancreatic cancer. Methods: In a randomized, open-label study, patients with locally advanced o
Autor:
Melanie Royce, Joan Kroener, Sarah S. Bacus, Elizabeth Curcio, Massimo Cristofanilli, Elsa M. Cora, Patrick Magill, Vicente Valero, Claire Watkins, Francis P. Arena, Aroop Mangalik, Ian Rabinowitz, Elizabeth Anderson
Publikováno v:
Clinical Cancer Research. 16:1904-1914
Purpose: This phase II randomized trial evaluated the efficacy and tolerability of anastrozole combined with gefitinib or anastrozole with placebo in women with hormone receptor–positive metastatic breast cancer (MBC). Experimental Design: Postmeno
Autor:
Elizabeth Crowley, Linda T. Vahdat, Randa Loutfi, Rebecca Bechhold, Robert Weaver, Michael Yellin, Dennis Citrin, Thomas Hawthorne, Thomas A. Davis, Scott Cruickshank, Francis P. Arena, Denise A. Yardley, Andres Forero, Michelle E. Melisko, Ira Oliff, Mansoor N. Saleh, Alison Stopeck, Tessa Cigler, Agustin A. Garcia, Jennifer Green
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 33(14)
Purpose Glycoprotein NMB (gpNMB), a negative prognostic marker, is overexpressed in multiple tumor types. Glembatumumab vedotin is a gpNMB-specific monoclonal antibody conjugated to the potent cytotoxin monomethyl auristatin E. This phase II study in
Autor:
Sharon Wilks, Luca Gianni, Zsuzsanna Papai, Shyanne Ali, Tetiana Taran, Jennifer K. Litton, David Chen, Kunwei Shen, Claudine Isaacs, Fabrice Andre, István Láng, Yoon Sim Yap, Francis P. Arena, Mustafa Ozguroglu, Anne C Armstrong, Michelle White, Norikazu Masuda, Ruth O'Regan, Guy Jerusalem, Binghe Xu, Masakazu Toi, Guillermo Lerzo, Yufen Zhang
Publikováno v:
The Lancet. Oncology. 15(6)
Summary Background Disease progression in patients with HER2-positive breast cancer receiving trastuzumab might be associated with activation of the PI3K/Akt/mTOR intracellular signalling pathway. We aimed to assess whether the addition of the mTOR i
Autor:
Mansoor N. Saleh, Malcolm J. Moore, Jeffrey R. Infante, Thomas J. Ervin, Eric Van Cutsem, Josep Tabernero, Daniel D. Von Hoff, Marion Harris, Francis P. Arena, Manuel Hidalgo, Xinyu Wei, E. Gabriela Chiorean, Wen Wee Ma, Nathan Bahary, David Goldstein, Daniel A. Laheru, Sergei Tjulandin, Scot Dowden, Ramesh K. Ramanathan, Michele Reni, Thomas E. Seay, Jose Iglesias, Markus F. Renschler
BACKGROUND In a phase 1–2 trial of albumin-bound paclitaxel (nab-paclitaxel) plus gemcitabine, substantial clinical activity was noted in patients with advanced pancreatic cancer. We conducted a phase 3 study of the efficacy and safety of the combi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bca36e04c6f2f6f441b1299ecfc2cc4
https://europepmc.org/articles/PMC4631139/
https://europepmc.org/articles/PMC4631139/