Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Francis P Kuhajda"'
Autor:
Joseph W McFadden, Susan Aja, Qun Li, Veera V R Bandaru, Eun-Kyoung Kim, Norman J Haughey, Francis P Kuhajda, Gabriele V Ronnett
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e115642 (2014)
Modification of hypothalamic fatty acid (FA) metabolism can improve energy homeostasis and prevent hyperphagia and excessive weight gain in diet-induced obesity (DIO) from a diet high in saturated fatty acids. We have shown previously that C75, a sti
Externí odkaz:
https://doaj.org/article/53736a7662d34e2aaa4b3122d532c78e
Autor:
Leslie E. Landree, Francis P. Kuhajda, Edward A. Wydysh, Khadija Daniels, Yajun Tu, Wan Fang Han, Susan M. Medghalchi, Jonathan M. Peterson, Craig A. Townsend, Kody Wong, Gabriele V. Ronnett, Susan Aja, Rajaa El Meskini
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 301:R116-R130
Storage of excess calories as triglycerides is central to obesity and its associated disorders. Glycerol-3-phosphate acyltransferases (GPATs) catalyze the initial step in acylglyceride syntheses, including triglyceride synthesis. We utilized a novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d90a0025cb30411f85b3328e144809b
https://doi.org/10.1152/ajpregu.00147.2011
https://doi.org/10.1152/ajpregu.00147.2011
Autor:
Tricia Tan, Francis P. Kuhajda, Gabriele V. Ronnett, Ismail Laher, Xavier Pi-Sunyer, Stephen R. Bloom, David S. Weigle
Publikováno v:
Molecular Interventions. 8:82-98
Obesity, defined by a body mass index greater than 30kg/m(2), claims an increasing number of lives every year, underscoring a dire need for effective therapeutic interventions. The origins of the obesity epidemic are complex, but commonly cited facto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::852e8465b7cbfed7af8f2ed6b5b9410d
https://doi.org/10.1124/mi.8.2.6
https://doi.org/10.1124/mi.8.2.6
Autor:
Matthew H. Kemm, Leslie E. Landree, Jagan N. Thupari, Francis P. Kuhajda, Jayson Hyun, Susan M. Medghalchi, Khadija Daniels, Erica Plummer, Andrea Aplasca, Susan Aja, Amy M. Kleman, Gabriele V. Ronnett, Craig A. Townsend, Aravinda Vadlamudi, Jill M. McFadden, Timothy H. Moran
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 294:R352-R361
Inhibition of brain carnitine palmitoyl-transferase-1 (CPT-1) is reported to decrease food intake and body weight in rats. Yet, the fatty acid synthase (FAS) inhibitor and CPT-1 stimulator C75 produces hypophagia and weight loss when given to rodents
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::501cd28916cdcec594873dcd0ed7cff6
https://doi.org/10.1152/ajpregu.00862.2006
https://doi.org/10.1152/ajpregu.00862.2006
Autor:
Jonathan Coulter, Ellen Tully, Edward Gabrielson, Colleen Lemmon, Aravinda Vadlamudi, Hajime Orita, Susan M. Medghalchi, Francis P. Kuhajda
Publikováno v:
Clinical Cancer Research. 13:7139-7145
Purpose: Fatty acid synthase (FAS) is overexpressed in many human cancers and is considered to be a promising target for therapy. However, in vitro use of previous generations of FAS inhibitors has been limited by severe, but reversible, anorexia in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1f75bbd0c5f83a4d4fab9c81050d795
https://doi.org/10.1158/1078-0432.ccr-07-1186
https://doi.org/10.1158/1078-0432.ccr-07-1186
Autor:
Gabriele V. Ronnett, Leslie E. Landree, Louise D. McCullough, Francis P. Kuhajda, Eun Kyoung Kim
Publikováno v:
Central Nervous System Agents in Medicinal Chemistry. 6:15-25
The regulation of cellular energy homeostasis within the CNS is crucial not only to neuronal survival, but to the brains function as an integrator of hormonal and neural inputs that regulate many functions, such as feeding behavior. The sensing and r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::869e30c4b18a9f2febc438ab3d1b7bfe
https://doi.org/10.2174/187152406776056564
https://doi.org/10.2174/187152406776056564
Publikováno v:
Current Medicinal Chemistry-Immunology, Endocrine & Metabolic Agents. 5:439-450
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f768808855f9cefd114552fe1c504c7b
https://doi.org/10.2174/156801305774322402
https://doi.org/10.2174/156801305774322402
Autor:
Poulikos I. Poulikakos, Deborah A. Altomare, Francis P. Kuhajda, Hui Qin Wang, Joseph R. Testa, Antonio Di Cristofano, Kristine L Skele
Publikováno v:
Oncogene. 24:3574-3582
Activation of AKT and overexpression of fatty acid synthase (FAS) are frequently observed in human ovarian cancer. To explore a possible connection between AKT and FAS, immunohistochemical analyses were conducted on an ovarian cancer tissue microarra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6e0e79b92e237f7a4df4130c60ab33d
https://doi.org/10.1038/sj.onc.1208463
https://doi.org/10.1038/sj.onc.1208463
Autor:
Susan M. Medghalchi, Jill M. Mcfadden, Michael L. Pinn, Aravinda Vadlamudi, Craig A. Townsend, Katherine I. Miller, Jagan N. Thupari, Francis P. Kuhajda
Publikováno v:
Journal of Medicinal Chemistry. 48:946-961
Fatty acid synthase (FAS) catalyzes the synthesis of palmitate from the sequential condensation of an acetyl primer with two carbon units added from malonyl-CoA. Inhibition of the beta-ketoacyl synthase domain of mammalian FAS leads to selective cyto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::534b3a33adbb647d92b83dc3ea8a66c9
https://doi.org/10.1021/jm049389h
https://doi.org/10.1021/jm049389h
Autor:
Francis P. Kuhajda, Eun Kyoung Kim, Leslie E. Landree, Susan Aja, Michael L. Pinn, Jill M. McFadden, Ian Miller, Timothy H. Moran, Gabriele V. Ronnett
Publikováno v:
Journal of Biological Chemistry. 279:19970-19976
Energy homeostasis and feeding are regulated by the central nervous system. C75, a fatty acid synthase (FAS) inhibitor, causes weight loss and anorexia, implying a novel central nervous system pathway(s) for sensing energy balance. AMP-activated prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4edf7aa4b7f10a1199b625063bae78ef
https://doi.org/10.1074/jbc.m402165200
https://doi.org/10.1074/jbc.m402165200