Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Francis M. Ndungu"'
Autor:
Robert M. Mugo, Benedict Orindi, Faiz M. Shee, Duncan Bellamy, Jedidah Mwacharo, Katie J. Ewer, Philip Bejon, Francis M. Ndungu
Publikováno v:
PLoS ONE, Vol 18, Iss 5 (2023)
Background RTS,S/AS01 induced anti-circumsporozoite protein (CSP) IgG antibodies are associated with the vaccine efficacy. There is currently no international standardisation of the assays used in the measurement of anti-CSP IgG antibody concentratio
Externí odkaz:
https://doaj.org/article/12c85a7e4d424b3e846eee3d51bed22a
Autor:
Robert M. Mugo, Kennedy Mwai, Jedidah Mwacharo, Faiz M. Shee, Jennifer N. Musyoki, Juliana Wambua, Edward Otieno, Philip Bejon, Francis M. Ndungu
Publikováno v:
Malaria Journal, Vol 20, Iss 1, Pp 1-8 (2021)
Abstract Background RTS,S/AS01, the leading malaria vaccine has been recommended by the WHO for widespread immunization of children at risk. RTS,S/AS01-induced anti-CSP IgG antibodies are associated with the vaccine efficacy. Here, the long-term kine
Externí odkaz:
https://doaj.org/article/f3598ba2fe95427294830402b185dbef
Autor:
Reagan M. Mogire, Alireza Morovat, John Muthii Muriuki, Alexander J. Mentzer, Emily L. Webb, Wandia Kimita, Francis M. Ndungu, Alex W. Macharia, Clare L. Cutland, Sodiomon B. Sirima, Amidou Diarra, Alfred B. Tiono, Swaib A. Lule, Shabir A. Madhi, Manjinder S. Sandhu, Andrew M. Prentice, Philip Bejon, John M. Pettifor, Alison M. Elliott, Adebowale Adeyemo, Thomas N. Williams, Sarah H. Atkinson
Publikováno v:
BMC Medicine, Vol 19, Iss 1, Pp 1-14 (2021)
Abstract Background Children living in sub-Saharan Africa have a high burden of rickets and infectious diseases, conditions that are linked to vitamin D deficiency. However, data on the vitamin D status of young African children and its environmental
Externí odkaz:
https://doaj.org/article/af36fc5b4df647808f587d75066738fb
Autor:
Peter Jahnmatz, Diana Nyabundi, Christopher Sundling, Linnea Widman, Jedidah Mwacharo, Jennifer Musyoki, Edward Otieno, Niklas Ahlborg, Philip Bejon, Francis M. Ndungu, Anna Färnert
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Identifying the mechanism of naturally acquired immunity against Plasmodium falciparum malaria could contribute to the design of effective malaria vaccines. Using a recently developed multiplexed FluoroSpot assay, we assessed cross-sectional pre-exis
Externí odkaz:
https://doaj.org/article/55ade425e9c54d8ebd694c0df15bbb79
Autor:
Mainga Hamaluba, Debra Riako, Betty Kalama, Francis M. Ndungu, Hope Mwangudzah, Saye Khoo, David G. Lalloo, Lawrence Babu, Richard FitzGerald, Michael Abouyannis, Benedict Orindi, Samson Ngome, Mwanajuma Ngama, Yvonne K. Nyambura, Laura Else, Frida Lewa, Noni Mumba, Ifedayo Adetifa, Sujan Dily Penchala, Nicholas R. Casewell
Publikováno v:
Wellcome Open Research, Vol 7 (2022)
Background: Snakebites affect over 5 million people each year, and over 100,000 per year die as a result. The only available treatment is antivenom, which has many shortcomings including high cost, intravenous administration, and high risk of adverse
Externí odkaz:
https://doaj.org/article/d23d9447885c40cdb89579bc43c2f874
Autor:
Jedida Mwacharo, Matt Berriman, Jean Langhorne, Francis M. Ndungu, Kevin Marsh, Jennifer Musyoki, John W.G. Addy, John Joseph Valletta, Joyce Mwongeli Ngoi, Philip Bejon, Yaw Bediako, Mario Recker, Joshua Wambua, Adam J. Reid, Chris I. Newbold, Khadija Said Mohammed, Edward Otieno
Publikováno v:
Wellcome Open Research, Vol 6 (2022)
After decades of research, our understanding of when and why individuals infected with Plasmodium falciparum develop clinical malaria is still limited. Correlates of immune protection are often sought through prospective cohort studies, where measure
Externí odkaz:
https://doaj.org/article/63369b7637934cea969bd98baf984384
Autor:
John Joseph Valetta, Jedida Mwacharo, Matthew Berriman, Jean Langhorne, Francis M. Ndungu, Kevin Marsh, Jennifer Musyoki, John W.G. Addy, Joyce Mwongeli Ngoi, Yaw Bediako, Philip Bejon, Mario Recker, Joshua Wambua, Adam J. Reid, Edward Otieno, Khadija Said Mohammed
Publikováno v:
Wellcome Open Research, Vol 6 (2022)
Background: Studies of long-term malaria cohorts have provided essential insights into how Plasmodium falciparum interacts with humans, and influences the development of antimalarial immunity. Immunity to malaria is acquired gradually after multiple
Externí odkaz:
https://doaj.org/article/3c6460d553e64a7b9d05aef883a961a6
Autor:
John Muthii Muriuki, Alexander J. Mentzer, Emily L. Webb, Alireza Morovat, Wandia Kimita, Francis M. Ndungu, Alex W. Macharia, Rosie J. Crane, James A. Berkley, Swaib A. Lule, Clare Cutland, Sodiomon B. Sirima, Amidou Diarra, Alfred B. Tiono, Philip Bejon, Shabir A. Madhi, Adrian V. S. Hill, Andrew M. Prentice, Parminder S. Suchdev, Alison M. Elliott, Thomas N. Williams, Sarah H. Atkinson
Publikováno v:
BMC Medicine, Vol 18, Iss 1, Pp 1-14 (2020)
Abstract Background Iron deficiency (ID) is a major public health burden in African children and accurate prevalence estimates are important for effective nutritional interventions. However, ID may be incorrectly estimated in Africa because most meas
Externí odkaz:
https://doaj.org/article/c4b8577e01b24a9aa3d0e11b1e8c3f55
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Chronic immune activation has been considered as the driving force for CD4+ T cell depletion in people infected with HIV-1. Interestingly, the normal immune profile of adult HIV-negative individuals living in Africa also exhibit chronic immune activa
Externí odkaz:
https://doaj.org/article/cbd345a6832c46c1815ec3f5e75ec547
Repeated clinical malaria episodes are associated with modification of the immune system in children
Autor:
Yaw Bediako, Rhys Adams, Adam J. Reid, John Joseph Valletta, Francis M. Ndungu, Jan Sodenkamp, Jedidah Mwacharo, Joyce Mwongeli Ngoi, Domtila Kimani, Oscar Kai, Juliana Wambua, George Nyangweso, Etienne P. de Villiers, Mandy Sanders, Magda Ewa Lotkowska, Jing-Wen Lin, Sarah Manni, John W. G. Addy, Mario Recker, Chris Newbold, Matthew Berriman, Philip Bejon, Kevin Marsh, Jean Langhorne
Publikováno v:
BMC Medicine, Vol 17, Iss 1, Pp 1-14 (2019)
Abstract Background There are over 200 million reported cases of malaria each year, and most children living in endemic areas will experience multiple episodes of clinical disease before puberty. We set out to understand how frequent clinical malaria
Externí odkaz:
https://doaj.org/article/bb064bb916684a2ca4a05449c002975e