Výsledky vyhledávání - "Francis M. Cuss"

A Comparison of Double-Strength Beclomethasone Dipropionate (84 μg) MDI With Beclomethasone Dipropionate (42 μ) MDI in the Treatment of Asthma

Autor: Francis M. Cuss, Robert A. Nathan, Richard R. Lorber, Keith B. Nolop

Publikováno v: Chest. 112:34-39

Study objective To compare the efficacy and safety of a double-strength formulation of beclomethasone dipropionate (BDP 84) metered-dose inhaler (MDI) with that of beclomethasone dipropionate (BDP 42) MDI in the treatment of chronic asthma. Design A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5e06e8859c70863e3e5bd6e024873d5d
https://doi.org/10.1378/chest.112.1.34

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Calcitonin gene-related peptide is localised to human airway nerves and potently constricts human airway smooth muscle

Autor: James B.D. Palmer, Julia M. Polak, Mohamed A. Ghatei, PK Mulderry, A Cadieux, Francis M. Cuss, Peter J. Barnes, Stephen R. Bloom, David R. Springall

Publikováno v: British Journal of Pharmacology. 91:95-101

In human airways synthetic human sequence calcitonin gene-related peptide (hCGRP), a novel peptide produced by alternative processing of mRNA from the calcitonin gene, caused concentration-dependent contraction of human bronchi (EC50 4.9 X 10(-9) M)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b64402874724a1b035193d58e8bc0f80
https://doi.org/10.1111/j.1476-5381.1987.tb08987.x

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The effect of inhaled nifedipine on bronchial reactivity to histamine in man

Autor: Francis M. Cuss, Peter J. Barnes

Publikováno v: Journal of Allergy and Clinical Immunology. 76:718-723

We have administered nifedipine by aerosol to six patients with mild asthma to determine whether local administration of a potent calcium channel blocker has any effect on resting airway tone or histamine reactivity. Subjects had their responsiveness

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f9199201e38a9312909b49a3eec6030
https://doi.org/10.1016/0091-6749(85)90677-3

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Breakdown of phosphoinositides in airway smooth muscle: lack of influence of anti-asthmatic drugs

Autor: Beatrice Grandordy, Francis M. Cuss, Peter J. Barnes

Publikováno v: Life sciences. 41(13)

Hydrolysis of membrane inositol phospholipids during agonist-induced contraction in bronchial smooth muscle leads to formation of inositol phosphates. Inositol phosphates are associated with intracellular Ca++ mobilization, which in smooth muscle lea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5d61211f86007bf387b6e776345a1e0
https://pubmed.ncbi.nlm.nih.gov/3041148

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The effect of airway epithelium on smooth muscle contractility in bovine trachea

Autor: Francis M. Cuss, Peter J. Barnes, J B Palmer

Publikováno v: British journal of pharmacology. 86(3)

In bovine tracheal smooth muscle the presence of airway epithelium significantly reduced the sensitivity and maximum contractile response to histamine, 5-hydroxytryptamine (5-HT) or acetylcholine. Muscle contraction induced by K+ and electrical field

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c8aa8970acaaa78da7ba651e46462b1
https://pubmed.ncbi.nlm.nih.gov/4063586

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Posture and theophylline kinetics

Autor: Peter J. Barnes, Francis M. Cuss, J.B. Warren

Publikováno v: British journal of clinical pharmacology. 19(5)

The effect of posture on theophylline kinetics was examined in six healthy men who took 450 mg slow-release aminophylline orally at the same time of day on two separate occasions. On one day they remained standing and on the other supine throughout.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa1a48e5fb2382da5320787ee8794e00
https://pubmed.ncbi.nlm.nih.gov/4005108

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