Zobrazeno 1 - 10
of 177
pro vyhledávání: '"Francis M Jiggins"'
Autor:
Shuyu Olivia Zhou, Ramesh Arunkumar, Amina Irfan, Shuai Dominique Ding, Alexandre B Leitão, Francis M Jiggins
Publikováno v:
PLoS Pathogens, Vol 20, Iss 1, p e1011729 (2024)
Both constitutive and inducible immune mechanisms are employed by hosts for defense against infection. Constitutive immunity allows for a faster response, but it comes with an associated cost that is always present. This trade-off between speed and f
Externí odkaz:
https://doaj.org/article/a8971a707b9c48c3b49d8c2b779cbcff
Autor:
Perran A Ross, Samia Elfekih, Sophie Collier, Melissa J Klein, Su Shyan Lee, Michael Dunn, Sarah Jackson, Yexin Zhang, Jason K Axford, Xinyue Gu, Jessica L Home, Majed S Nassar, Prasad N Paradkar, Essam A Tawfik, Francis M Jiggins, Abdulaziz M Almalik, Mohamed B Al-Fageeh, Ary A Hoffmann
Publikováno v:
PLoS Pathogens, Vol 19, Iss 1, p e1011117 (2023)
Aedes aegypti mosquitoes carrying self-spreading, virus-blocking Wolbachia bacteria are being deployed to suppress dengue transmission. However, there are challenges in applying this technology in extreme environments. We introduced two Wolbachia str
Externí odkaz:
https://doaj.org/article/ee96bdeb1b3e41a090721b41c0ac7b5a
Autor:
Shuai Dominique Ding, Alexandre B Leitão, Jonathan P Day, Ramesh Arunkumar, Morgan Phillips, Shuyu Olivia Zhou, Francis M Jiggins
Publikováno v:
PLoS Genetics, Vol 18, Iss 11, p e1010453 (2022)
When an animal is infected, the expression of a large suite of genes is changed, resulting in an immune response that can defend the host. Despite much evidence that the sequence of proteins in the immune system can evolve rapidly, the evolution of g
Externí odkaz:
https://doaj.org/article/a260983ef01f47b39cdd6af40ac8004c
Autor:
Alexandre B Leitão, Ramesh Arunkumar, Jonathan P Day, Emma M Geldman, Ismaël Morin-Poulard, Michèle Crozatier, Francis M Jiggins
Publikováno v:
eLife, Vol 9 (2020)
Organisms rely on inducible and constitutive immune defences to combat infection. Constitutive immunity enables a rapid response to infection but may carry a cost for uninfected individuals, leading to the prediction that it will be favoured when inf
Externí odkaz:
https://doaj.org/article/b00a684d2c534fdbbc21d8b55e2bbd35
Autor:
Samuel H Lewis, Laura Ross, Stevie A Bain, Eleni Pahita, Stephen A Smith, Richard Cordaux, Eric A Miska, Boris Lenhard, Francis M Jiggins, Peter Sarkies
Publikováno v:
PLoS Genetics, Vol 16, Iss 6, p e1008864 (2020)
Cytosine methylation is an ancient epigenetic modification yet its function and extent within genomes is highly variable across eukaryotes. In mammals, methylation controls transposable elements and regulates the promoters of genes. In insects, DNA m
Externí odkaz:
https://doaj.org/article/7951cbc5c39449c3908f02bb355e6640
Autor:
Alexandre B Leitão, Xueni Bian, Jonathan P Day, Simone Pitton, Eşref Demir, Francis M Jiggins
Publikováno v:
PLoS Pathogens, Vol 15, Iss 10, p e1008084 (2019)
It is common to find abundant genetic variation in host resistance and parasite infectivity within populations, with the outcome of infection frequently depending on genotype-specific interactions. Underlying these effects are complex immune defenses
Externí odkaz:
https://doaj.org/article/ad8196a0cbd94941b71b9babbd249736
Autor:
Jessamyn I Perlmutter, Sarah R Bordenstein, Robert L Unckless, Daniel P LePage, Jason A Metcalf, Tom Hill, Julien Martinez, Francis M Jiggins, Seth R Bordenstein
Publikováno v:
PLoS Pathogens, Vol 15, Iss 9, p e1007936 (2019)
Wolbachia are the most widespread maternally-transmitted bacteria in the animal kingdom. Their global spread in arthropods and varied impacts on animal physiology, evolution, and vector control are in part due to parasitic drive systems that enhance
Externí odkaz:
https://doaj.org/article/377e739c26ae45a69f479690e2d6b034
Autor:
Elizabeth ML Duxbury, Jonathan P Day, Davide Maria Vespasiani, Yannik Thüringer, Ignacio Tolosana, Sophia CL Smith, Lucia Tagliaferri, Altug Kamacioglu, Imogen Lindsley, Luca Love, Robert L Unckless, Francis M Jiggins, Ben Longdon
Publikováno v:
eLife, Vol 8 (2019)
It is common to find considerable genetic variation in susceptibility to infection in natural populations. We have investigated whether natural selection increases this variation by testing whether host populations show more genetic variation in susc
Externí odkaz:
https://doaj.org/article/624025c10f434438a89a90bb98bd816b
Autor:
Ben Longdon, Jonathan P Day, Joel M Alves, Sophia C L Smith, Thomas M Houslay, John E McGonigle, Lucia Tagliaferri, Francis M Jiggins
Publikováno v:
PLoS Pathogens, Vol 14, Iss 4, p e1006951 (2018)
Host shifts, where a pathogen invades and establishes in a new host species, are a major source of emerging infectious diseases. They frequently occur between related host species and often rely on the pathogen evolving adaptations that increase thei
Externí odkaz:
https://doaj.org/article/0c3640a2bf4c44c0b065d9ec2f28ecb3
Autor:
John E McGonigle, Alexandre B Leitão, Sarah Ommeslag, Sophie Smith, Jonathan P Day, Francis M Jiggins
Publikováno v:
PLoS Pathogens, Vol 13, Iss 10, p e1006683 (2017)
A priority for biomedical research is to understand the causes of variation in susceptibility to infection. To investigate genetic variation in a model system, we used flies collected from single populations of three different species of Drosophila a
Externí odkaz:
https://doaj.org/article/cc7ba26c952d443b9ceb3185a968a250