Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Francis M Hughes"'
Publikováno v:
BMC Urology, Vol 24, Iss 1, Pp 1-11 (2024)
Abstract Background One of the most common, but least studied, diabetic complication is diabetic bladder dysfunction. Current therapies include glucose control and symptom-based interventions. However, efficacy of these therapies is mixed and often h
Externí odkaz:
https://doaj.org/article/2dcae694afff4061aec71ecfe978ba5a
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 29, Iss 4, p 154 (2024)
Background: Diabetic bladder dysfunction (DBD) is driven in part by inflammation which dysregulates prostaglandin release in the bladder. Precise inflammatory mechanisms responsible for such dysregulation have been elusive. Since prostaglandins impac
Externí odkaz:
https://doaj.org/article/115df09a5c39451dbc4ea60a3b5baca7
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Diabetes is a rapidly expanding epidemic projected to affect as many as 1 in 3 Americans by 2050. This disease is characterized by devastating complications brought about high glucose and metabolic derangement. The most common of these complications
Externí odkaz:
https://doaj.org/article/876c33714b004b2e9e9276e1a58b8da8
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2821 (2023)
Anecdotal evidence has long suggested that patients with lower urinary tract symptoms (LUTS) develop mood disorders, such as depression and anxiety, at a higher rate than the general population and recent prospective studies have confirmed this link.
Externí odkaz:
https://doaj.org/article/29f1c996f44248f1a18ee9626afea96a
Publikováno v:
American Journal of Physiology-Renal Physiology. 323:F616-F632
Approximately half of the patients with diabetes develop diabetic bladder dysfunction (DBD). The initiation and progression of DBD is largely attributed to inflammation due to dysregulated glucose and the production of toxic metabolites that activate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9fedf2fded366e9ad9bafeb497c55d5
https://doi.org/10.1152/ajprenal.00047.2022
https://doi.org/10.1152/ajprenal.00047.2022
Autor:
Francis M. Hughes, Armand Allkanjari, Michael R. Odom, Jack E. Mulcrone, Huixia Jin, J. Todd Purves
Publikováno v:
American Journal of Physiology-Renal Physiology.
Diabetic Bladder Dysfunction (DBD) is a prevalent diabetic complication that is recalcitrant to glucose control. Using the Akita mouse model (type 1) bred to be NLRP3+/+ or NLRP3-/-, we previously found that females (mild hyperglycemia) progress from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28893c5a45124d42357f32a34429f175
https://doi.org/10.1152/ajprenal.00284.2022
https://doi.org/10.1152/ajprenal.00284.2022
Publikováno v:
Int Urol Nephrol
PURPOSE: To determine the unique contributions from elevated voiding and storage pressures in the development of fibrosis and the epithelial-to-mesenchymal transition (EMT) in urothelial cells, and how progressive BOO pressure cycling is an important
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac4a66d0d949691f422045ac443e619d
https://doi.org/10.1007/s11255-021-02942-3
https://doi.org/10.1007/s11255-021-02942-3
Autor:
Byron W. Hayes, Francis M. Hughes, Cassandra Phoenix, Yuxuan Miao, Gustavo Sosa Macias, R. Lee Reinhardt, J. Todd Purves, Jianxuan Wu, Soman N. Abraham, Hae Woong Choi
Publikováno v:
Nature immunology
Urinary tract infections (UTIs) typically evoke prompt and vigorous innate bladder immune responses, including extensive exfoliation of the epithelium. To explain the basis for the extraordinarily high recurrence rates of UTIs, we examined adaptive i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d20c31e672be3c6e4026a98182c0d9b9
https://doi.org/10.1038/s41590-020-0688-3
https://doi.org/10.1038/s41590-020-0688-3
Autor:
Simon W. White, William T Harrison, Isabelle Doan, Nathan Hirshman, Huixia Jin, J. Todd Purves, Patrick D Leidig, Francis M. Hughes, Shelby N. Harper
Publikováno v:
Am J Physiol Renal Physiol
Recent breakthroughs demonstrate that peripheral diseases can trigger inflammation in the brain, causing psychosocial maladies, including depression. While few direct studies have been made, anecdotal reports associate urological disorders with menta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b3afdcf1716848320ea54eb18a96ec7
https://doi.org/10.1152/ajprenal.00408.2019
https://doi.org/10.1152/ajprenal.00408.2019
Publikováno v:
Life Sci
AIMS: Diabetic bladder dysfunction (DBD) is a prevalent diabetic complication thought to progress from overactive (OAB) to underactive (UAB) bladder. Previously we found OAB at 15 weeks in the Akita mouse, a genetic model of Type 1 diabetes. The firs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c7f074421f381808cc3cc91dc49e814
https://pubmed.ncbi.nlm.nih.gov/35381220
https://pubmed.ncbi.nlm.nih.gov/35381220