Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Francis Leopardi"'
Autor:
Robin Schmitz, Robert Patrick Davis, Qimeng Gao, Allan D. Kirk, Bradley H. Collins, Mingqing Song, Niki Huffman, Francis Leopardi, Zachary W. Fitch, Benjamin M. Martin, Gayathri R. Devi, Kannan P. Samy
Publikováno v:
Xenotransplantation
Background Thrombosis is a known consequence of intraportal islet transplantation, particularly for xenogeneic islets. To define the origins of thrombosis after islet xenotransplantation and relate it to early inflammation, we examined porcine islets
Autor:
Francis Leopardi, Adela R. Cardones, Mingqing Song, Jean Kwun, Linda C. Cendales, Dimitrios Moris, MacKenzie McRae, Andrew Atia, K.D. Williams, Linda Stempora, Allan D. Kirk, William Parker
Publikováno v:
Transplant International. 33
Vascularized composite allotransplantation (VCA) is challenged by the morbidity of immunosuppression required to prevent rejection. The use of highly specific biologics has not been well explored in VCA. Given that psoriasis is T-cell mediated, as is
Autor:
Tam How, Francis Leopardi, Robert Patrick Davis, J. Cano, Benjamin M. Martin, Bradley H. Collins, K.D. Williams, Gayathri R. Devi, Kannan P. Samy, Anna G. McDonald, Qimeng Gao, Alton B. Farris, E.K. Gall, C.R. Dove, M. Song, Allan D. Kirk
Publikováno v:
American Journal of Transplantation. 18:998-1006
Porcine islet xenografts have the potential to provide an inexhaustible source of islets for β cell replacement. Proof-of-concept has been established in nonhuman primates. However, significant barriers to xenoislet transplantation remain, including
Autor:
Bradley H. Collins, T.A. Springer, C. Lu, Allan D. Kirk, Keith A. Reimann, K.D. Williams, Francis Leopardi, S.C. Kachlany, K.S. Franke, B.S. Parker, Andrea L. MacDonald, Alton B. Farris, D.A. Anderson, Denise J. Lo, M. Song, Tam How, Michael S. Mulvihill, Kannan P. Samy
Publikováno v:
American Journal of Transplantation. 17:1193-1203
Costimulation blockade (CoB) via belatacept is a lower morbidity alternative to calcineurin inhibitor (CNI)-based immunosuppression. However, it has higher rates of early acute rejection. These early rejections are mediated in part by memory T cells,
Autor:
Douglas J. Anderson, Elizabeth Strobert, Joe B. Jenkins, Denise J. Lo, Mingqing Song, Francis Leopardi, Allan D. Kirk, Christian P. Larsen
Publikováno v:
Clin Transplant
Belatacept, the CD28-B7 costimulation pathway inhibitor, has been approved as a calcineurin inhibitor (CNI) alternative in kidney transplantation. Although costimulation blockade (CoB) allows for CNI avoidance, it is associated with increased rates o
Autor:
Allan D. Kirk, Francis Leopardi, Keith A. Reimann, Christian P. Larsen, Denise J. Lo, Joe B. Jenkins, Nicole A. Turgeon, Mingqing Song, Rijian Wang, Douglas J. Anderson, Elizabeth Strobert
Publikováno v:
American Journal of Transplantation. 16:1456-1464
Costimulation blockade with the fusion protein belatacept provides a desirable side effect profile and improvement in renal function compared with calcineurin inhibition in renal transplantation. This comes at the cost of increased rates of early acu
Autor:
Alton B. Farris, JA Jenkins, M. Song, Alessandrina M. Freitas, Linda Stempora, Allan D. Kirk, Kannan P. Samy, Linda C. Cendales, Francis Leopardi, Elizabeth Strobert
Publikováno v:
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 15(8)
Vascularized composite allografts (VCAs) are technically feasible. Similar to other organ transplants, VCAs are hampered by the toxicity and incomplete efficacy associated with conventional immunosuppression. Complications attributable to calcineurin