Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Francis L. Earl"'
Publikováno v:
Toxicology and Applied Pharmacology. 37:319-330
The enzymic activities of 9000g supernatant fractions obtained from the livers of normal beagle dogs and miniature swine and of dogs and swine treated with lindane and phenobarbital are presented. No significant sex differences in activities were not
Autor:
Victor J. Ferrans, Tibor Balazs, Stephen Krop, Robert S.K. Young, Eugene H. Herman, Francis L. Earl
Publikováno v:
Toxicology and Applied Pharmacology. 47:493-503
Minoxidil, a vasodilating antihypertensive drug, was given orally in doses of 0.5, 1.0, or 3.0 mg/kg to adult Beagle dogs on 2 consecutive days. Within 2 hr of administration, each of these doses produced hypotension and a marked tachycardia which pe
Publikováno v:
Toxicology and Applied Pharmacology. 33:498-504
Diazoxide, a vasodilating antihypertensive drug, caused tachycardia when given to dogs as iv doses of 10–40 mg/kg. Doses of 20–40 mg/kg, given on 2 or 3 consecutive days, caused myocardial necroses similar to that produced by hydralazine. The pap
Publikováno v:
Toxicology and Applied Pharmacology. 29:47-52
An accelerated metabolism and consequent decreased activity of vitamin D3 has been considered to be responsible for the osteomalacia associated with the use of anticonvulsant drugs. To investigate the effects of sodium phenobarbital and sodium diphen
Autor:
T.M. Farber, G.W. Bierbower, David L. Ritter, Morris A. Weinberger, James T. Tanner, Celester J. Carter, Francis L. Earl, Edward J. Van Loon, Melvin H. Friedman
Publikováno v:
Toxicology. 5:319-336
Miniature swine were fed brominated sesame oil at dietary levels of 0, 5, 25, 50 or 500 mg/kg of body weight for 17 weeks and brominated soybean oil at levels of 0, 5, 50 or 500 mg/kg of body weight for 28 weeks. Growth rate and food intake were decr
Publikováno v:
Toxicology and Applied Pharmacology. 18:285-295
Beagle dogs and Hormel-Hanford swine survived single oral doses of 300 or 500 mg/kg of diazinon. In addition, 4 daily doses of 50 mg/kg/day were tolerated. Dogs survived as long as 15 days and swine up to 30 days at doses of 25 mg/kg/day, although 2
Publikováno v:
Toxicology and Applied Pharmacology. 13:392-403
Carbaryl (1-naphthyl- N -methyl carbamate; Sevin), a reversible cholinesterase-inhibiting insecticide, was incorporated into the feed of pregnant beagle dogs and fed throughout the gestational period at levels of 50, 25, 12.5, 6.25, and 3.125 mg/kg b
Publikováno v:
Food and Cosmetics Toxicology. 9:819-828
Beagle dogs and miniature swine were fed dichloran (2.6-dichloro-4-nitroaniline) at levels of 0.75, 6.0, 24, 48 or 192 mg/kg/day in the diet for periods of 50–306 days. Corneal opacities appeared in the eyes of dogs given the 24- or 48-mg levels in
Publikováno v:
Archives of Environmental Health: An International Journal. 13:776-787
Autor:
Mushtaq A. Khan, Marshall L. Rennels, Michael S. Forbes, T.M. Farber, S. David Gertz, Muhammad M. Husain, Felix P. Heald, Eugene Miller, Francis L. Earl, Erland Nelson
Publikováno v:
Experimental and molecular pathology. 26(1)
The effects of feeding an experimental diet containing 16.25% (w/w) dry powdered egg yolk and 30.8% total fat (20% from lard) were compared with an isocaloric amount of control (stock) diet in castrated (N = 11 each) and sham-operated (N = 8 each) ma