Zobrazeno 1 - 10
of 407
pro vyhledávání: '"Francis Lévi"'
Autor:
Sylvie Giacchetti, Enora Laas, Thomas Bachelot, Jérome Lemonnier, Fabrice André, David Cameron, Judith Bliss, Sylvie Chabaud, Anne-Claire Hardy- Bessard, Magali Lacroix-Triki, Jean-Luc Canon, Marc Debled, Mario Campone, Paul Cottu, Florence Dalenc, Annabelle Ballesta, Frederique Penault-Llorca, Bernard Asselain, Elise Dumas, Fabien Reyal, Paul Gougis, Francis Lévi, Anne-Sophie Hamy
Publikováno v:
EBioMedicine, Vol 104, Iss , Pp 105141- (2024)
Summary: Background: Circadian rhythms regulate cellular physiology and could influence the efficacy of endocrine therapy (ET) in breast cancer (BC). We prospectively tested this hypothesis within the UNIRAD adjuvant phase III trial (NCT01805271). Me
Externí odkaz:
https://doaj.org/article/9f42a221348c45659c954d1962e5d5fe
Autor:
Craig Gouldthorpe, Sonia Ancoli-Israel, Elizabeth Cash, Pasquale Innominato, Gunnhild Jakobsen, Francis Lévi, Christine Miaskowski, Arti Parganiha, Atanu Kumar Pati, Deidre Pereira, Victoria Revell, Jamie M. Zeitzer, Andrew Davies
Publikováno v:
Cancers, Vol 15, Iss 15, p 3784 (2023)
Purpose: Circadian rest–Activity Rhythm Disorders (CARDs) are common in patients with cancer, particularly in advanced disease. CARDs are associated with increased symptom burden, poorer quality of life, and shorter survival. Research and reporting
Externí odkaz:
https://doaj.org/article/c3a94b29388c48568f2df4f4b6b3fddc
Autor:
Brice Faraut, Emilie Cordina-Duverger, Guillen Aristizabal, Catherine Drogou, Caroline Gauriau, Fabien Sauvet, Francis Lévi, Damien Léger, Pascal Guénel
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
ObjectivesWe aimed to examine the effects of circadian and sleep rhythm disruptions on immune biomarkers among hospital healthcare professionals working night shifts and rotating day shifts.MethodsHospital nurses working either as permanent night shi
Externí odkaz:
https://doaj.org/article/4e7f204669e141c6ac95c5d1a93eaa84
Autor:
Yiyuan Zhang, Emilie Cordina-Duverger, Sandra Komarzynski, Amal M. Attari, Qi Huang, Guillen Aristizabal, Brice Faraut, Damien Léger, René Adam, Pascal Guénel, Julia A. Brettschneider, Bärbel F. Finkenstädt, Francis Lévi
Publikováno v:
EBioMedicine, Vol 81, Iss , Pp 104121- (2022)
Summary: Background: Telemonitoring of circadian and sleep cycles could identify shift workers at increased risk of poor health, including cancer and cardiovascular diseases, thus supporting personalized prevention. Methods: The Circadiem cross-secti
Externí odkaz:
https://doaj.org/article/ea4806b99cd541fe993d9b383d8c058b
Autor:
Manuel Spitschan, Nayantara Santhi, Amrita Ahluwalia, Dorothee Fischer, Lilian Hunt, Natasha A Karp, Francis Lévi, Inés Pineda-Torra, Parisa Vidafar, Rhiannon White
Publikováno v:
eLife, Vol 11 (2022)
Growing evidence shows that sex differences impact many facets of human biology. Here we review and discuss the impact of sex on human circadian and sleep physiology, and we uncover a data gap in the field investigating the non-visual effects of ligh
Externí odkaz:
https://doaj.org/article/f119125cadf64eb6bf223214de317f6f
Autor:
Abdoulaye Karaboué, Thierry Collon, Ida Pavese, Viviane Bodiguel, Joel Cucherousset, Elda Zakine, Pasquale F. Innominato, Mohamed Bouchahda, René Adam, Francis Lévi
Publikováno v:
Cancers, Vol 14, Iss 4, p 896 (2022)
Hypothesis: Prior experimental and human studies have demonstrated the circadian organization of immune cells’ proliferation, trafficking, and antigen recognition and destruction. Nivolumab targets T(CD8) cells, the functions, and trafficking of wh
Externí odkaz:
https://doaj.org/article/dfcf1f1fab6d46a297f6fdbef4319186
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 1, p e1007218 (2020)
Precision medicine requires accurate technologies for drug administration and proper systems pharmacology approaches for patient data analysis. Here, plasma pharmacokinetics (PK) data of the OPTILIV trial in which cancer patients received oxaliplatin
Externí odkaz:
https://doaj.org/article/7784ee135eda414fb09d3a891895dd4b
Autor:
Francis Lévi, Sandra Komarzynski, Qi Huang, Teresa Young, Yeng Ang, Claire Fuller, Matei Bolborea, Julia Brettschneider, Joanna Fursse, Bärbel Finkenstädt, David Pollard White, Pasquale Innominato
Publikováno v:
Cancers, Vol 12, Iss 7, p 1938 (2020)
The dichotomy index (I < O), a quantitative estimate of the circadian regulation of daytime activity and sleep, predicted overall cancer survival and emergency hospitalization, supporting its integration in a mHealth platform. Modifiable causes of I
Externí odkaz:
https://doaj.org/article/883505ad5b074268aa96ddcdf0ce5099
Autor:
Alper Okyar, Enza Piccolo, Constance Ahowesso, Elisabeth Filipski, Virginie Hossard, Catherine Guettier, Rosanna La Sorda, Nicola Tinari, Stefano Iacobelli, Francis Lévi
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20393 (2011)
ATP-binding cassette transporter abcc2 is involved in the cellular efflux of irinotecan. The drug is toxic for mouse ileum, where abcc2 is highly expressed. Here, we investigate whether circadian changes in local abcc2 expression participate in the c
Externí odkaz:
https://doaj.org/article/0b992a758eb04a5eb17a712b49020b65
Publikováno v:
PLoS Computational Biology, Vol 6, Iss 3, p e1000712 (2010)
In host and cancer tissues, drug metabolism and susceptibility to drugs vary in a circadian (24 h) manner. In particular, the efficacy of a cell cycle specific (CCS) cytotoxic agent is affected by the daily modulation of cell cycle activity in the ta
Externí odkaz:
https://doaj.org/article/37d9041d671b4aed8bbe453939ca2d67