Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Francis Kappler"'
Autor:
Mitchell R. Smith, Truman R. Brown, Francis Kappler, Kristen Padavic-Shaller, Suzanne E Franks, Calvin Shaller, William G. Negendank, Yun Zhang, Fernando Arias-Mendoza
Publikováno v:
Leukemia Research. 26:919-926
Levels of phospholipid-related metabolites of chronic lymphocytic leukemia lymphocytes (CLL) and normal human lymphocytes were quantified using phosphorus magnetic resonance spectroscopy. The CLL cells versus normal lymphocytes showed significant inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::572a598843d443ef2a3bc8a555cf2380
https://doi.org/10.1016/s0145-2126(02)00035-8
https://doi.org/10.1016/s0145-2126(02)00035-8
Publikováno v:
Metabolism. 44:1527-1531
Production of unusual phosphorylated metabolites in the lens is one of several changes caused by hyperglycemia. Sorbitol 3-phosphate (Sor-3P) and fructose 3-phosphate (Fru-3P) are two such compounds identified in the diabetic lens, and galactitol 2-p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e1442fd057b7ca9425314327b051074
https://doi.org/10.1016/0026-0495(95)90069-1
https://doi.org/10.1016/0026-0495(95)90069-1
Autor:
Sundeep Lal, Truman R. Brown, Benjamin S. Szwergold, Francis Kappler, Anne Taylor, Bangying Su
Publikováno v:
Diabetes. 44:810-815
Using 31P–nuclear magnetic resonance spectroscopy, we have identified elevated concentrations of sedoheptulose-7-phosphate (S-7-P) in lenses from three animal models of hyperglycemia: streptozotocin-induced diabetic rats, galactose-fed rats, and xy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::035a4327207e8b3cae66b0645bd2dc92
https://doi.org/10.2337/diab.44.7.810
https://doi.org/10.2337/diab.44.7.810
Publikováno v:
NMR in Biomedicine. 7:121-127
Tumors and transformed cells have been shown by 31P NMR to contain elevated concentrations of two phosphomonoesters, phosphorylcholine and phosphorylethanolamine, involved in phospholipid metabolism. In order to understand the biochemical basis for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0232a6e67d30fd85a652c0486ce65bd
https://doi.org/10.1002/nbm.1940070304
https://doi.org/10.1002/nbm.1940070304
Publikováno v:
Current Eye Research. 13:239-242
Extracellular and intracellular pH has been shown to be an important physiological variable in many biological systems. However, studies on the effect of pH on the metabolic status of the mammalian lens have been few. It has been shown previously tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07ff35af8841df8bb9ce9518614d9599
https://doi.org/10.3109/02713689408995783
https://doi.org/10.3109/02713689408995783
Publikováno v:
Journal of Biological Chemistry. 268:7763-7767
Recently we have identified two novel phosphorylated metabolites in the lenses of diabetic rats as sorbitol 3-phosphate (Sor-3-P) and fructose 3-phosphate (Fru-3-P). The latter compound is of particular interest since it is a potent glycating agent,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f37271e78b20311e4b05df44f15e0d98
https://doi.org/10.1016/s0021-9258(18)53023-4
https://doi.org/10.1016/s0021-9258(18)53023-4
Publikováno v:
Biochemical Journal. 284:363-366
In human erythrocytes, the first step in the metabolism of fructose is generally thought to be phosphorylation to fructose 6-phosphate catalysed by hexokinase. In variance with this assumption, we show here that fructose in these cells is metabolized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daaf6f3a947010ecd24a83986c334729
https://doi.org/10.1042/bj2840363
https://doi.org/10.1042/bj2840363
Autor:
Benjamin S. Szwergold, Alan J. Benesi, Dominique Rolin, Stanley F. Osman, Philip E. Pfeffer, Francis Kappler
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1116:215-225
In our previous in vivo 31P study of intact nitrogen-fixing nodules (Rolin, D.B., Boswell, R.T., Sloger, C., Tu, S.I. and Pfeffer, P.E., 1989 Plant Physiol. 89, 1238-1246), we observed an unknown phosphodiester. The compound was also observed in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09808faf336d708733a1b3efb1bb38c3
https://doi.org/10.1016/0304-4165(92)90014-l
https://doi.org/10.1016/0304-4165(92)90014-l
Publikováno v:
Journal of Biological Chemistry. 265:17424-17427
Using 31P NMR spectroscopy, we have identified sorbitol 3-phosphate and fructose 3-phosphate in normal human erythrocytes wherein their concentrations are estimated to be 13 mumol/liter cells. Incubation of hemolysates with sorbitol, fructose and ATP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e3b9aee81f6a6fb32c0cea646a128c8
https://doi.org/10.1016/s0021-9258(18)38178-x
https://doi.org/10.1016/s0021-9258(18)38178-x
Publikováno v:
Biochemical and Biophysical Research Communications. 172:855-861
A novel metabolite of choline, phosphorylcholine methyl ester, has been identified in the eggs of S. purpuratus wherein it is present at ∼ 1mM concentration. To the best of our knowledge, this is the first instance of a phosphoryl-methyl-ester to b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75585226e2c2fa765a863585c90197bd
https://doi.org/10.1016/0006-291x(90)90754-b
https://doi.org/10.1016/0006-291x(90)90754-b