Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Francis K, Yoshimoto"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 16, p 9020 (2024)
Cytochrome P450 (P450) enzymes dominate steroid metabolism. In general, the simple C-hydroxylation reactions are mechanistically straightforward and are generally agreed to involve a perferryl oxygen species (formally FeO3+). Several of the steroid t
Externí odkaz:
https://doaj.org/article/360b5c5b8f9b41ccb18e32215ad5370d
Publikováno v:
Organic & Biomolecular Chemistry. 21:3172-3176
Menarandroside A, which bears a 12α-hydroxypregnenolone steroid backbone, was isolated from the plant, Cynanchum menarandrense. This natural product was synthesized from dehydroepiandrosterone (DHEA).
Autor:
Hadi D. Arman, Tu M. Ho, Kaitlyn Varela, Cynthia S. Veliz, Richard B. Zanni, Armando Rodriguez, Zhiwei Wang, Francis K. Yoshimoto
Publikováno v:
Journal of Chemical Education.
Autor:
Kaitlyn Varela, Hafij Al Mahmud, Hadi D. Arman, Luis R. Martinez, Catherine A. Wakeman, Francis K. Yoshimoto
Publikováno v:
J Nat Prod
Dihydroartemisinic acid (DHAA) is a plant natural product that undergoes a spontaneous endoperoxide-forming cascade reaction to yield artemisinin in the presence of air. The endoperoxide functional group gives artemisinin its biological activity that
Publikováno v:
Journal of Natural Products. 84:1967-1984
Artemisinin is the plant natural product used to treat malaria. The endoperoxide bridge of artemisinin confers its antiparasitic properties. Dihydroartemisinic acid is the biosynthetic precursor of artemisinin that was previously shown to nonenzymati
Publikováno v:
The Protein Journal
Coronavirus disease 2019 (COVID-19), which is the pandemic caused by the virus, severe acute respiratory syndrome coronavirus-2 (SARS CoV-2), first appearing in December 2019, continues to confound the world. In this update we provide insights into h
Autor:
Francis K. Yoshimoto
Publikováno v:
The Protein Journal
The global pandemic that shut down the world in 2020 was caused by the virus, SARS CoV-2. The chemistry of the various nonstructural proteins (NSP3, NSP5, NSP12, NSP13, NSP14, NSP15, NSP16) of SARS CoV-2 is discussed. Secondly, a recent major focus o
Publikováno v:
Journal of Natural Products. 83:66-78
Dihydroartemisinic acid is the biosynthetic precursor to artemisinin, the endoperoxide-containing natural product used to treat malaria. The conversion of dihydroartemisinic acid to artemisinin is a cascade reaction that involves C-C bond cleavage, h
Publikováno v:
Steroids. 186:109088
The Schönecker oxidation involves the 12beta-hydroxylation of 17-imino pyridine DHEA derivatives using copper and either molecular oxygen or hydrogen peroxide as the oxidant. In this study, a 19-imino pyridine DHEA derivative was synthesized and was
Publikováno v:
Journal of natural products. 84(7)
Artemisinin is the plant natural product used to treat malaria. The endoperoxide bridge of artemisinin confers its antiparasitic properties. Dihydroartemisinic acid is the biosynthetic precursor of artemisinin that was previously shown to nonenzymati