Zobrazeno 1 - 10
of 163
pro vyhledávání: '"Francis Jacob"'
Autor:
Thorsten Schaefer, Nitish Mittal, Hui Wang, Meric Ataman, Silvia Candido, Jonas Lötscher, Sergiy Velychko, Lionel Tintignac, Thomas Bock, Anastasiya Börsch, Jochen Baßler, Tata Nageswara Rao, Jakub Zmajkovic, Sarah Roffeis, Jordan Löliger, Francis Jacob, Alain Dumlin, Christoph Schürch, Alexander Schmidt, Radek C. Skoda, Matthias P. Wymann, Christoph Hess, Hans R. Schöler, Holm Zaehres, Ed Hurt, Mihaela Zavolan, Claudia Lengerke
Publikováno v:
Cell Reports, Vol 43, Iss 10, Pp 114807- (2024)
Summary: Stemness and pluripotency are mediated by transcriptional master regulators that promote self-renewal and repress cell differentiation, among which is the high-mobility group (HMG) box transcription factor SOX2. Dysregulated SOX2 expression,
Externí odkaz:
https://doaj.org/article/3f4435c1df914aa5bdc0b2931130faf7
Autor:
Kathrin B. Labrosse, Flavio C. Lombardo, Natalie Rimmer, Mónica Núñez López, André Fedier, Viola Heinzelmann-Schwarz, Ricardo Coelho, Francis Jacob
Publikováno v:
STAR Protocols, Vol 5, Iss 3, Pp 103274- (2024)
Summary: Three-dimensional (3D) ex vivo cultures allow the study of cancer progression and drug resistance mechanisms. Here, we present a protocol for measuring on-target drug sensitivity in a scaffold-free 3D culture system through quantification of
Externí odkaz:
https://doaj.org/article/7878e94092734d8e99c5e69881ee4ebf
Autor:
Lenka Kasikova, Jana Rakova, Michal Hensler, Tereza Lanickova, Jana Tomankova, Josef Pasulka, Jana Drozenova, Katerina Mojzisova, Anna Fialova, Sarka Vosahlikova, Jan Laco, Ales Ryska, Pavel Dundr, Roman Kocian, Tomas Brtnicky, Petr Skapa, Linda Capkova, Marek Kovar, Jan Prochazka, Ivan Praznovec, Vladimir Koblizek, Alice Taskova, Hisashi Tanaka, Robert Lischke, Fernando Casas Mendez, Jiri Vachtenheim, Viola Heinzelmann-Schwarz, Francis Jacob, Iain A. McNeish, Michal J. Halaska, Lukas Rob, David Cibula, Sandra Orsulic, Lorenzo Galluzzi, Radek Spisek, Jitka Fucikova
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Intratumoral tertiary lymphoid structures (TLSs) have been associated with improved outcome in various cohorts of patients with cancer, reflecting their contribution to the development of tumor-targeting immunity. Here, we demonstrate that h
Externí odkaz:
https://doaj.org/article/51ecc26da57243349eb37f9d6e8d150d
Autor:
Arthur Dondi, Ulrike Lischetti, Francis Jacob, Franziska Singer, Nico Borgsmüller, Ricardo Coelho, Tumor Profiler Consortium, Viola Heinzelmann-Schwarz, Christian Beisel, Niko Beerenwinkel
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Understanding the complex background of cancer requires genotype-phenotype information in single-cell resolution. Here, we perform long-read single-cell RNA sequencing (scRNA-seq) on clinical samples from three ovarian cancer patients presen
Externí odkaz:
https://doaj.org/article/a6ca4dd2f21440459a66c8a701729688
Autor:
Katharine A. Barrett, Francis Jacob Kassama, William Surks, Andrew J. Mulholland, Karen D. Moulton, Danielle H. Dube
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
IntroductionThe pathogenic bacterium Helicobacter pylori has evolved glycan-mediated mechanisms to evade host immune defenses. This study tests the hypothesis that genetic disruption of H. pylori glycan biosynthesis alters immune recognition and resp
Externí odkaz:
https://doaj.org/article/e690178a884a41e28a98a60f5f828bf9
Autor:
Fabienne D. Schwab, Manuel C. Scheidmann, Lauren L. Ozimski, André Kling, Lucas Armbrecht, Till Ryser, Ilona Krol, Karin Strittmatter, Bich Doan Nguyen-Sträuli, Francis Jacob, André Fedier, Viola Heinzelmann-Schwarz, Andreas Wicki, Petra S. Dittrich, Nicola Aceto
Publikováno v:
Microsystems & Nanoengineering, Vol 8, Iss 1, Pp 1-11 (2022)
Abstract Cancer patients with advanced disease are characterized by intrinsic challenges in predicting drug response patterns, often leading to ineffective treatment. Current clinical practice for treatment decision-making is commonly based on primar
Externí odkaz:
https://doaj.org/article/bf251c3a1c404b639047bcf71de7b3ad
Autor:
Ricardo Coelho, Alessandra Tozzi, Muriel Disler, Flavio Lombardo, André Fedier, Mónica Núñez López, Florian Freuler, Francis Jacob, Viola Heinzelmann-Schwarz
Publikováno v:
Cell Death and Disease, Vol 13, Iss 10, Pp 1-13 (2022)
Abstract PARP inhibitors (PARPi) have revolutionized the therapeutic landscape of epithelial ovarian cancer (EOC) treatment with outstanding benefits in regard to progression-free survival, especially in patients either carrying BRCA1/2 mutations or
Externí odkaz:
https://doaj.org/article/dc5ab75700d94ee09c33c23ff0a4a4ac
Generation of endogenously tagged E-cadherin cells using gene editing via non-homologous end joining
Publikováno v:
STAR Protocols, Vol 4, Iss 2, Pp 102305- (2023)
Summary: We provide a protocol using non-homologous end joining to integrate an oligonucleotide sequence of a fluorescence protein at the CDH1 locus encoding for the epithelial glycoprotein E-cadherin. We describe steps for implementing the CRISPR-Ca
Externí odkaz:
https://doaj.org/article/afdcb0e1a13442128cdfeef619702a44
Autor:
Francis Jacob, Rosa Lina Marchetti, André B. Kind, Kenneth Russell, Andreas Schoetzau, Viola A. Heinzelmann‐Schwarz
Publikováno v:
Molecular Oncology, Vol 15, Iss 1, Pp 91-103 (2021)
In the era of personalized medicine, where transition from organ‐based to individualized genetic diagnosis takes place, the tailoring of treatment in cancer becomes increasingly important. This is particularly true for high‐grade, advanced FIGO s
Externí odkaz:
https://doaj.org/article/071df08e308f4d2393146cce94a83a3a
Autor:
Yen-Lin Huang, Ching-Yeu Liang, Vera Labitzky, Danilo Ritz, Tiago Oliveira, Cécile Cumin, Manuela Estermann, Tobias Lange, Arun V. Everest-Dass, Francis Jacob
Publikováno v:
iScience, Vol 24, Iss 10, Pp 103168- (2021)
Summary: Integrin alpha 2 (ITGA2) promotes cancer metastasis through selective adhesion to ECM proteins; however, the specific contribution of integrin glycosylation remains uncertain. We provide evidence that ITGA2 is a highly glycosylated transmemb
Externí odkaz:
https://doaj.org/article/e81193d18188454cbcfd5b064d5807a9