Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Francis J. Roushar"'
Autor:
Patrick Carmody, Francis J. Roushar, Austin Tedman, Madeline Herwig, Minsoo Kim, Eli F. McDonald, Jennifer Wong-Roushar, Jon-Luc Poirier, Nathan B. Zelt, Ben T. Pockrass, Andrew G. McKee, Charles P. Kuntz, Lars Plate, Wesley D. Penn, Jonathan P. Schlebach
The cotranslational misfolding of the cystic fibrosis transmembrane conductance regulator (CFTR) plays a central role in the molecular basis of cystic fibrosis (CF). The misfolding of the most common CF variant (ΔF508) remodels both the translationa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::009df340500f9e9d1716c507b65b9e3a
https://doi.org/10.1101/2023.05.02.539166
https://doi.org/10.1101/2023.05.02.539166
Autor:
Andrew G. McKee, Eli F. McDonald, Wesley D. Penn, Charles P. Kuntz, Karen Noguera, Laura M. Chamness, Francis J. Roushar, Jens Meiler, Kathryn E. Oliver, Lars Plate, Jonathan P. Schlebach
Publikováno v:
Cell Chemical Biology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9501f312c1e0216fff34da5cd41e992
https://doi.org/10.1016/j.chembiol.2023.05.001
https://doi.org/10.1016/j.chembiol.2023.05.001
Publikováno v:
Journal of Cell Biology. 222
The scaffold protein IQGAP1 assembles multiprotein signaling complexes to influence biological functions. Cell surface receptors, particularly receptor tyrosine kinases and G-protein coupled receptors, are common IQGAP1 binding partners. Interactions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b81bea51d7c00cf60389221d70df419c
https://doi.org/10.1083/jcb.202205062
https://doi.org/10.1083/jcb.202205062
Autor:
Andrew G. McKee, Eli F. McDonald, Wesley D. Penn, Charles P. Kuntz, Karen Noguera, Laura M. Chamness, Francis J. Roushar, Jens Meiler, Kathryn E. Oliver, Lars Plate, Jonathan P. Schlebach
Cystic fibrosis (CF) is a chronic genetic disease caused by mutations that compromise the expression and/ or function of the cystic fibrosis transmembrane conductance regulator chloride channel (CFTR). Most people with CF harbor a common misfolded CF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7584e1d85192eff5486f78007991047
https://doi.org/10.1101/2022.10.14.512300
https://doi.org/10.1101/2022.10.14.512300
Autor:
Francis J. Roushar, Andrew G. McKee, Charles P. Kuntz, Joseph T. Ortega, Wesley D. Penn, Hope Woods, Laura M. Chamness, Victoria Most, Jens Meiler, Beata Jastrzebska, Jonathan P. Schlebach
Over 100 mutations in the rhodopsin gene have been linked to a spectrum of retinopathies that include retinitis pigmentosa and congenital stationary night blindness. Though most of these variants exhibit a loss of function, the molecular defects caus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b3e64c2136852a74992b2808a73cff3
https://doi.org/10.1101/2022.03.01.482516
https://doi.org/10.1101/2022.03.01.482516
Autor:
Francis J. Roushar, Andrew G. McKee, Charles P. Kuntz, Joseph T. Ortega, Wesley D. Penn, Hope Woods, Laura M. Chamness, Victoria Most, Jens Meiler, Beata Jastrzebska, Jonathan P. Schlebach
Publikováno v:
Journal of Biological Chemistry. 298:102266
Over 100 mutations in the rhodopsin gene have been linked to a spectrum of retinopathies that include retinitis pigmentosa and congenital stationary night blindness. Though most of these variants exhibit a loss of function, the molecular defects caus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dc5cb2d388b7b1c268b9c596bfca86a
https://doi.org/10.1016/j.jbc.2022.102266
https://doi.org/10.1016/j.jbc.2022.102266
Autor:
Veronica Nash, Andrew G. McKee, Hope Woods, Jens Meiler, Mahesh S. Chandak, Douglas B. Rusch, Charles P. Kuntz, Chris Hemmerich, Wesley D. Penn, Timothy C. Gruenhagen, Francis J. Roushar, Jonathan P. Schlebach
Publikováno v:
Science Advances
Sequence constraints associated with topological energetics restrict the evolution and mutational tolerance of membrane proteins.
Membrane proteins must balance the sequence constraints associated with folding and function against the hydrophobi
Membrane proteins must balance the sequence constraints associated with folding and function against the hydrophobi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7181e33c7c3b9c034c2bc6d56f3bf56e
http://europepmc.org/articles/PMC7056298
http://europepmc.org/articles/PMC7056298
Autor:
Jens Meiler, Jonathan P. Schlebach, Wesley D. Penn, Beata Jastrzebska, Bian Li, Timothy C. Gruenhagen, Francis J. Roushar
Publikováno v:
Journal of the American Chemical Society. 141:204-215
Membrane proteins are prone to misfolding and degradation within the cell, yet the nature of the conformational defects involved in this process remain poorly understood. The earliest stages of membrane protein folding are mediated by the Sec61 trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e63b2436991aa62cdef2a4f0b4761f97
https://doi.org/10.1021/jacs.8b08243
https://doi.org/10.1021/jacs.8b08243
Autor:
Adam W. Smith, Jonathan P. Schlebach, Francis J. Roushar, D. Paul Mallory, Margaret Pinkevitch, Elizabeth Gutierrez, William D. Comar, Beata Jastrzebska, Christie Klinginsmith
Publikováno v:
Biochemistry. 57:5188-5201
G protein-coupled receptors can exist as dimers and higher-order oligomers in biological membranes. The specific oligomeric assembly of these receptors is believed to play a major role in their function, and the disruption of native oligomers has bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00bb89a28bbc11549ae98f087788308b
https://doi.org/10.1021/acs.biochem.8b00403
https://doi.org/10.1021/acs.biochem.8b00403
Autor:
Jens Meiler, Hope Woods, Jonathan P. Schlebach, Beata Jastrzebska, Charles P. Kuntz, Joseph T. Ortega, Francis J. Roushar, Victoria Most, Andrew G. McKee
Publikováno v:
The Journal of Biological Chemistry
Membrane protein variants with diminished conformational stability often exhibit enhanced cellular expression at reduced growth temperatures. The expression of "temperature-sensitive" variants is also typically sensitive to corrector molecules that b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9142578362bd4d540ceabc59ad0ffcb2
https://doi.org/10.1016/j.jbc.2021.101359
https://doi.org/10.1016/j.jbc.2021.101359