Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Francis J. Prael, III"'
Autor:
Francis J. Prael, III, Jiayi Cox, Noé Sturm, Peter Kutchukian, William C. Forrester, Gregory Michaud, Jutta Blank, Lingling Shen, Raquel Rodríguez-Pérez
Publikováno v:
Artificial Intelligence in the Life Sciences, Vol 6, Iss , Pp 100100- (2024)
Targeted protein degradation (TPD) is a rapidly developing drug discovery technique with unique efficacy and target scope stemming from its degradation-based activity. Molecular glue degraders are a promising arm of TPD, as evidenced by the FDA-appro
Externí odkaz:
https://doaj.org/article/55a983e8b68c47b29a24a8f5a592f2c3
Autor:
Francis J. Prael III, Kwangho Kim, Yu Du, Brittany D. Spitznagel, Gary A. Sulikowski, Eric Delpire, C. David Weaver
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
KCC2 is a K+-Cl− cotransporter that is expressed in neurons throughout the central nervous system. Deficits in KCC2 activity have been implicated in a variety of neurological disorders, including epilepsy, chronic pain, autism spectrum disorders, a
Externí odkaz:
https://doaj.org/article/494279392eab412885fe7d235f350b87