Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Francis J. Golder"'
Publikováno v:
Respiratory Physiology & Neurobiology. 189(2):395-402
Drug-induced respiratory depression (DIRD) is a common problem encountered post-operatively and can persist for days after surgery. It is not always possible to predict the timing or severity of DIRD due to the number of contributing factors. A safe
Publikováno v:
Veterinary Anaesthesia and Analgesia. 37:471-477
Observations A 22‐month‐old male neutered Coton De Tulear dog was presented for upper gastrointestinal endoscopy under general anesthesia. The anesthetic plan included premedication with intramuscular meperidine (4 mg kg −1 ) but meperidine was
Publikováno v:
The Journal of Physiology. 588:255-266
Phrenic long term facilitation (pLTF) is a form of respiratory plasticity induced by acute intermittent hypoxia. pLTF requires spinal serotonin receptor activation, new BDNF synthesis and TrkB receptor activation. Spinal adenosine 2A (A2A) receptor a
Autor:
Mary Rachael Lovett-Barr, Irawan Satriotomo, Gordon S. Mitchell, Francis J. Golder, Lavanya Ranganathan, Tracy L. Baker-Herman, Jyoti J. Watters, Michael S. Hoffman
Publikováno v:
The Journal of Neuroscience. 28:2033-2042
Acute intermittent hypoxia elicits a form of spinal, brain-derived neurotrophic factor (BDNF)-dependent respiratory plasticity known as phrenic long-term facilitation. Ligands that activate Gs-protein-coupled receptors, such as the adenosine 2a recep
Autor:
Andrew Peter Kennedy, Michael R. Van Scott, Ryan B. Gruber, Toshinori Hoshi, David Ritchie, Richard Woodward, Francis J. Golder, Robert L. Wardle, Courtney Ideo, Veljko Puskovic, Scott L. Dax, Santhosh M. Baby, Sean Peng, James C. Mannion, D. Euan MacIntyre
Publikováno v:
Anesthesiology. 123(5)
Background The authors describe the preclinical pharmacological properties of GAL-021, a novel peripheral chemoreceptor modulator. Methods The ventilatory effects of GAL-021 were characterized using tracheal pneumotachometry (n = 4 to 6), plethysmogr
Autor:
Mark L, Dallas, Chris, Peers, Francis J, Golder, Santhosh, Baby, Ryan, Gruber, D Euan, MacIntyre
Publikováno v:
Advances in experimental medicine and biology. 860
GAL-021 and GAL-160 are alkylamino triazine analogues, which stimulate ventilation in rodents, non-human primates and (for GAL-021) in humans. To probe the site and mechanism of action of GAL-021 and GAL-160 we utilized spirometry in urethane anesthe
Publikováno v:
The FASEB Journal. 29
Autor:
Ryan B. Gruber, Mark L. Dallas, Chris Peers, Santhosh M. Baby, D. Euan MacIntyre, Francis J. Golder
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9783319184395
GAL-021 and GAL-160 are alkylamino triazine analogues, which stimulate ventilation in rodents, non-human primates and (for GAL-021) in humans. To probe the site and mechanism of action of GAL-021 and GAL-160 we utilized spirometry in urethane anesthe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9281519804c0ffabe8fe88685fc9dd24
https://doi.org/10.1007/978-3-319-18440-1_41
https://doi.org/10.1007/978-3-319-18440-1_41
Publikováno v:
Journal of Applied Physiology. 100:800-806
We tested two hypotheses: 1) that the spontaneous enhancement of phrenic motor output below a C2spinal hemisection (C2HS) is associated with plasticity in ventrolateral spinal inputs to phrenic motoneurons; and 2) that phrenic motor recovery in anest
Autor:
Francis J. Golder, Gordon S. Mitchell
Publikováno v:
The Journal of Neuroscience. 25:2925-2932
Respiratory insufficiency is the leading cause of death after high-cervical spinal cord injuries (SCIs). Although respiratory motor recovery can occur with time after injury, the magnitude of spontaneous recovery is limited. We hypothesized that part