Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Francis J. Burrows"'
Autor:
Rolf A. Brekken, Michael T. Dellinger, Francis J. Burrows, Noah B. Sorrelle, Huocong Huang, Amanda Kirane, Yuqing Zhang
Supplementary Figure 1. (a) Representative images of metastasis to the liver of control mice in Colo357 model was shown by H&E staining. Total magnifications are 100X and 200X. Scale bar, 50μm. (b) Colo357 human pancreatic cancer cells (1 × 10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7445e0e18bcc467ee9416c74f72b5f59
https://doi.org/10.1158/1541-7786.22513384.v1
https://doi.org/10.1158/1541-7786.22513384.v1
Autor:
Atanasio Pandiella, Azucena Esparís-Ogando, Francis J. Burrows, Jesús San Miguel, Enrique M. Ocio, Sara Zaknoen, Tracy Parrott, María Jesús Ortiz-Ruiz, Stela Álvarez-Fernández
Ex vivo effect of TG02 on primary myeloma cells analyzed in each of the patients separately.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d82089d4a89dc04e2731678b697ebd7
https://doi.org/10.1158/1078-0432.22446573.v1
https://doi.org/10.1158/1078-0432.22446573.v1
Autor:
Atanasio Pandiella, Azucena Esparís-Ogando, Francis J. Burrows, Jesús San Miguel, Enrique M. Ocio, Sara Zaknoen, Tracy Parrott, María Jesús Ortiz-Ruiz, Stela Álvarez-Fernández
Kinases inhibited by TG02 in the low nM range.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ad550009ba7c2eaa7a16a81e49ae7c9
https://doi.org/10.1158/1078-0432.22446555
https://doi.org/10.1158/1078-0432.22446555
Autor:
Atanasio Pandiella, Azucena Esparís-Ogando, Francis J. Burrows, Jesús San Miguel, Enrique M. Ocio, Sara Zaknoen, Tracy Parrott, María Jesús Ortiz-Ruiz, Stela Álvarez-Fernández
Purpose: To analyze the antimyeloma potential of TG02, an ERK5/CDK inhibitory drug.Experimental Design: Utilizing different multiple myeloma cell lines we determined the effect of TG02 over viability by MTT assays. The apoptotic effect over multiple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::992eac3a070d9fa9c2a0355ce6083f3e
https://doi.org/10.1158/1078-0432.c.6520782
https://doi.org/10.1158/1078-0432.c.6520782
Publikováno v:
Cancers, Vol 14, Iss 86, p 86 (2022)
Cancers
Cancers
Simple Summary Pancreatic cancer is a challenging disease to treat effectively. Fibroblasts associated with pancreatic cancer contribute to disease progression by secreting factors that enhance tumor cell survival and help tumor cells avoid detection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b27a7190c3b0e1315f4450644db8085
https://doi.org/10.3390/cancers14010086
https://doi.org/10.3390/cancers14010086
Autor:
Francis J Burrows, Martin Gore, W Russell Smiley, Martha Y Kanemitsu, Douglas J Jolly, Susana B Read, Thomas Nicholas, Carol A Kruse
Publikováno v:
Cancer Gene Therapy. 9:87-95
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f036f94b9593da29a8a3b3978b485746
https://doi.org/10.1038/sj/cgt/7700401
https://doi.org/10.1038/sj/cgt/7700401
Autor:
Douglas J. Jolly, Thomas Nicholas, Francis J. Burrows, Susana B. Read, Carol A. Kruse, Martha Y Kanemitsu, Martin Gore, W Russell Smiley
Publikováno v:
Cancer Gene Therapy. 9:87-95
An important consequence of the suicide gene therapeutic paradigm is the phenomenon of bystander cell killing, the death of adjacent tumor cells not transduced with the thymidine kinase (TK) gene from herpes simplex virus (HSV) after treatment with t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d725bfdead0d97ea1c4ab2b7a559167b
https://doi.org/10.1038/sj.cgt.7700401
https://doi.org/10.1038/sj.cgt.7700401
Autor:
Nadine Ognoskie, Dee Wynne, Gloria Peters, Ronald Kerr, Francis J. Burrows, Timothy Fong, Fred B. Oldham, Dale Ando, Janet Bruce, Wally Meyer, John Nemunaitis, John Pippen
Publikováno v:
Human Gene Therapy. 10:1289-1298
The purpose of this study was to determine the safety and antitumor activity of IFN-gamma retroviral vector in patients with advanced melanoma. Seventeen patients (9 single courses, 8 multiple courses) received a total of 363 intratumor injections of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ccf3cb733c4dca9312fe6001bf7f684
https://doi.org/10.1089/10430349950017978
https://doi.org/10.1089/10430349950017978
Autor:
Adeela, Kamal, Francis J, Burrows
Publikováno v:
Discovery medicine. 4(23)
Extract: Cancer drug discovery has traditionally focused on targeting DNA synthesis and cell division, resulting in drugs that show efficacy but have severe side effects, due to their lack of selectivity for tumor cells over normal cells. One truly t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9809fd0e33c8033b8f5b7cb30b9d9a00
https://pubmed.ncbi.nlm.nih.gov/20704959
https://pubmed.ncbi.nlm.nih.gov/20704959
Autor:
Srinivas R, Kasibhatla, Kevin, Hong, Marco A, Biamonte, David J, Busch, Patricia L, Karjian, John L, Sensintaffar, Adeela, Kamal, Rachel E, Lough, John, Brekken, Karen, Lundgren, Roy, Grecko, Gregg A, Timony, Yingqing, Ran, Robert, Mansfield, Lawrence C, Fritz, Edgar, Ulm, Francis J, Burrows, Marcus F, Boehm
Publikováno v:
Journal of medicinal chemistry. 50(12)
Heat shock protein 90 (Hsp90) is a molecular chaperone protein implicated in stabilizing the conformation and maintaining the function of many cell-signaling proteins. Many oncogenic proteins are more dependent on Hsp90 in maintaining their conformat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7d4b2feee8ee425cef56bd83ad21acf6
https://pubmed.ncbi.nlm.nih.gov/17488003
https://pubmed.ncbi.nlm.nih.gov/17488003