Výsledky vyhledávání - "Francis J Miller"

Akademický článek

Towards monitoring of critical illness via the detection of histones with extended gate field-effect transistor sensors

Autor: Hayley Richardson, Jeffrey Barahona, Greg Medwig, Angela Johns, Lina M. Acosta Pérez, Koji Sode, Michael Daniele, Francis J. Miller, Edgar Lobaton, Spyridon Pavlidis

Publikováno v: Biosensors and Bioelectronics: X, Vol 19, Iss , Pp 100501- (2024)

Extracellular histone proteins in the blood indicate a heightened risk of morbidity after trauma or in major illnesses such as sepsis. We present the development of an aptasensor for histone detection with an extended gate field-effect transistor (EG

Externí odkaz: https://doaj.org/article/c30c234929ae4466a71e321a55556f56

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Akademický článek

The multifunctional Ca²⁺/calmodulin-dependent kinase IIδ (CaMKIIδ) regulates arteriogenesis in a mouse model of flow-mediated remodeling.

Publikováno v: PLoS ONE, Vol 8, Iss 8, p e71550 (2013)

OBJECTIVE:Sustained hemodynamic stress mediated by high blood flow promotes arteriogenesis, the outward remodeling of existing arteries. Here, we examined whether Ca²⁺/calmodulin-dependent kinase II (CaMKII) regulates arteriogenesis. METHODS AND R

Externí odkaz: https://doaj.org/article/a6212747293a4b058e5501de611d149f

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Akademický článek

Rapid identification of cell-specific, internalizing RNA aptamers with bioinformatics analyses of a cell-based aptamer selection.

Autor: William H Thiel, Thomas Bair, Andrew S Peek, Xiuying Liu, Justin Dassie, Katie R Stockdale, Mark A Behlke, Francis J Miller, Paloma H Giangrande

Publikováno v: PLoS ONE, Vol 7, Iss 9, p e43836 (2012)

The broad applicability of RNA aptamers as cell-specific delivery tools for therapeutic reagents depends on the ability to identify aptamer sequences that selectively access the cytoplasm of distinct cell types. Towards this end, we have developed a

Externí odkaz: https://doaj.org/article/89e7a8b78bce46dea63ccda58900cb55

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Akademický článek

Smooth muscle cell-targeted RNA ligand promotes accelerated reendothelialization in a swine peripheral injury model

Autor: Beilei Lei, Linda B. Liu, Lauren Stokes, Paloma H. Giangrande, Francis J. Miller, Jr., Saami K. Yazdani

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 34, Iss , Pp 102023- (2023)

The local delivery of antiproliferative agents to inhibit neointimal growth is not specific to vascular smooth muscle cells (VSMC) and delays reendothelialization and vascular healing. This investigation was intended to evaluate the effect of luminal

Externí odkaz: https://doaj.org/article/45a81757d7534d55ac6af4b27abbb0b3

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Akademický článek

Inhalation of an RNA aptamer that selectively binds extracellular histones protects from acute lung injury

Autor: Beilei Lei, Chaojian Wang, Kamie Snow, Murilo E. Graton, Robert M. Tighe, Ammon M. Fager, Maureane R. Hoffman, Paloma H. Giangrande, Francis J. Miller, Jr.

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 31, Iss , Pp 662-673 (2023)

Acute lung injury (ALI) is a syndrome of acute inflammation, barrier disruption, and hypoxemic respiratory failure associated with high morbidity and mortality. Diverse conditions lead to ALI, including inhalation of toxic substances, aspiration of g

Externí odkaz: https://doaj.org/article/60455e7ecf584a589b079e930bb50ded

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Akademický článek

Local intraluminal delivery of a smooth muscle-targeted RNA ligand inhibits neointima growth in a porcine model of peripheral vascular disease

Autor: Saami K. Yazdani, Beilei Lei, Claire V. Cawthon, Kathryn Cooper, Clifton Huett, Paloma H. Giangrande, Francis J. Miller, Jr.

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 29, Iss , Pp 577-583 (2022)

Anti-proliferative agents have been the primary therapeutic drug of choice to inhibit restenosis after endovascular treatment. However, recent safety and efficacy concerns for patients who underwent peripheral artery disease revascularization have de

Externí odkaz: https://doaj.org/article/f60ad065679042edbbf850287c0647ad

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Akademický článek

Comparative study between apocynin and protocatechuic acid regarding antioxidant capacity and vascular effects

Autor: Murilo E. Graton, Bruno H. S. H. Ferreira, Jéssica A. Troiano, Simone R. Potje, Gabriel T. Vale, Ana Cláudia M. S. Nakamune, Carlos R. Tirapelli, Francis J. Miller, Valdecir F. Ximenes, Cristina Antoniali

Publikováno v: Frontiers in Physiology, Vol 13 (2022)

Reactive oxygen species (ROS) derived from NOX enzymes activity play an important role in the development of cardiovascular diseases. Compounds able to decrease oxidative stress damage are potential candidates as drugs and/or supplements for hyperten

Externí odkaz: https://doaj.org/article/0b19805f06d248b493922ff66483a5c5

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The endothelial-enriched lncRNA LINC00607 mediates angiogenic function

Publikováno v: Basic Research in Cardiology, 118(1):5. Springer
Boos, F, Oo, J A, Warwick, T, Günther, S, Izquierdo Ponce, J, Lopez, M, Rafii, D, Buchmann, G, Pham, M D, Msheik, Z S, Li, T, Seredinski, S, Haydar, S, Kashefiolasl, S, Plate, K H, Behr, R, Mietsch, M, Krishnan, J, Pullamsetti, S S, Bibli, S, Hinkel, R, Baker, A H, Boon, R A, Schulz, M H, Wittig, I, Miller, F J, Brandes, R P & Leisegang, M S 2023, ' The endothelial-enriched lncRNA LINC00607 mediates angiogenic function ', Basic research in cardiology, vol. 118, no. 1, 5 . https://doi.org/10.1007/s00395-023-00978-3
Boos, F, Oo, J A, Warwick, T, G?nther, S, Izquierdo Ponce, J, Lopez, M, Rafii, D, Buchmann, G, Pham, M D, Msheik, Z S, Li, T, Seredinski, S, Haydar, S, Kashefiolasl, S, Plate, K H, Behr, R D, Mietsch, M, Krishnan, J, Pullamsetti, S S, Bibli, S-I, Hinkel, R, Baker, A H, Boon, R A, Schulz, M H, Wittig, I, Miller, F J, Brandes, R P & Leisegang, M S 2023, ' The endothelial-enriched lncRNA LINC00607 mediates angiogenic function ', Basic Research in Cardiology, vol. 118, no. 1, 5 . https://doi.org/10.1007/s00395-023-00978-3
Basic Research in Cardiology, 118(1):5. D. Steinkopff-Verlag

Long non-coding RNAs (lncRNAs) can act as regulatory RNAs which, by altering the expression of target genes, impact on the cellular phenotype and cardiovascular disease development. Endothelial lncRNAs and their vascular functions are largely undefin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ebbb1adb912075138984c27d421e77e
https://doi.org/10.1007/s00395-023-00978-3

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Akademický článek

RNA inhibitors of nuclear proteins responsible for multiple organ dysfunction syndrome

Autor: Kevin T. Urak, Giselle N. Blanco, Shambhavi Shubham, Li-Hsien Lin, Justin P. Dassie, William H. Thiel, Yani Chen, Vijay Kumar Sonkar, Beilei Lei, Shubha Murthy, Wade R. Gutierrez, Mary E. Wilson, Jonathan A. Stiber, Julia Klesney-Tait, Sanjana Dayal, Francis J. Miller, Paloma H. Giangrande

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

Multiple organ dysfunction syndrome (MODS) is a serious event that can occur following infection or tissue injury, and is partly mediated by histones released in circulation. Here, the authors develop aptamers that neutralise histones involved in MOD

Externí odkaz: https://doaj.org/article/d86b6e4d36f645ec80b0587ff0507135

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