Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Francis J McNally"'
Autor:
Elizabeth A Beath, Cynthia Bailey, Meghana Mahantesh Magadam, Shuyan Qiu, Karen L McNally, Francis J McNally
Publikováno v:
eLife, Vol 13 (2024)
Fertilization occurs before the completion of oocyte meiosis in the majority of animal species and sperm contents move long distances within the zygotes of mouse and C. elegans. If incorporated into the meiotic spindle, paternal chromosomes could be
Externí odkaz:
https://doaj.org/article/fd9defef573148fbb4a053f5684871c2
Publikováno v:
PLoS Genetics, Vol 19, Iss 12, p e1011090 (2023)
Oocyte meiotic spindles mediate the expulsion of ¾ of the genome into polar bodies to generate diploid zygotes in nearly all animal species. Failures in this process result in aneuploid or polyploid offspring that are typically inviable. Accurate me
Externí odkaz:
https://doaj.org/article/1364b39c97884b858d8c3eb1cec38f15
Autor:
Karen P McNally, Elizabeth A Beath, Brennan M Danlasky, Consuelo Barroso, Ting Gong, Wenzhe Li, Enrique Martinez-Perez, Francis J McNally
Publikováno v:
PLoS Genetics, Vol 18, Iss 10, p e1010136 (2022)
Accurate chromosome segregation requires a cohesin-mediated physical attachment between chromosomes that are to be segregated apart, and a bipolar spindle with microtubule plus ends emanating from exactly two poles toward the paired chromosomes. We a
Externí odkaz:
https://doaj.org/article/8a80bd3aaa3e4fb3bcc091f424568ecf
Publikováno v:
eLife, Vol 4 (2015)
Trisomy, the presence of a third copy of one chromosome, is deleterious and results in inviable or defective progeny if passed through the germ line. Random segregation of an extra chromosome is predicted to result in a high frequency of trisomic off
Externí odkaz:
https://doaj.org/article/d7a51c57753e4fdea9a68034e59306da
Autor:
Liza O'Donnell, Danielle Rhodes, Stephanie J Smith, D Jo Merriner, Brett J Clark, Claire Borg, Belinda Whittle, Anne E O'Connor, Lee B Smith, Francis J McNally, David M de Kretser, Chris C Goodnow, Chris J Ormandy, Duangporn Jamsai, Moira K O'Bryan
Publikováno v:
PLoS Genetics, Vol 8, Iss 5, p e1002698 (2012)
Katanin is an evolutionarily conserved microtubule-severing complex implicated in multiple aspects of microtubule dynamics. Katanin consists of a p60 severing enzyme and a p80 regulatory subunit. The p80 subunit is thought to regulate complex targeti
Externí odkaz:
https://doaj.org/article/2997ff13e1264b80bb3d72a00a9d1b87
Autor:
Ting Gong, Francis J McNally
Publikováno v:
Genetics. 223
Chromosome segregation errors during meiosis are the leading cause of aneuploidy. Faithful chromosome segregation during meiosis in most eukaryotes requires a crossover which provides a physical attachment holding homologs together in a “bivalent.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76f6b4f8d9cb521ef0b26feda744f5c7
https://doi.org/10.1093/genetics/iyad021
https://doi.org/10.1093/genetics/iyad021
Autor:
Karen P. McNally, Elizabeth A. Beath, Brennan M. Danlasky, Consuelo Barroso, Ting Gong, Wenzhe Li, Enrique Martinez-Perez, Francis J. McNally
Publikováno v:
PLoS genetics, vol 18, iss 10
Accurate chromosome segregation requires a cohesin-mediated physical attachment between chromosomes that are to be segregated apart, and a bipolar spindle with microtubule plus ends emanating from exactly two poles toward the paired chromosomes. We a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9c832be13f2fbe3aa6d0333a1adb013
https://escholarship.org/uc/item/3hh4g9jm
https://escholarship.org/uc/item/3hh4g9jm
Autor:
Karen Perry McNally, Brennan Danlasky, Consuelo Barroso, Ting Gong, Wenzhe Li, Enrique Martinez-Perez, Francis J. McNally
Accurate chromosome segregation requires a cohesin-mediated physical attachment between chromosomes that are to be segregated apart, and a bipolar spindle with microtubule plus ends emanating from exactly two poles toward the paired chromosomes. We a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e77f11181528a8d0c6aa87ebc917d2f5
https://doi.org/10.1101/2022.03.10.483728
https://doi.org/10.1101/2022.03.10.483728
Publikováno v:
microPublication Biology
RMD-1,2,3,6 (regulator of microtubule dynamics) is a family of homologous proteins conserved between humans and C. elegans. Human RMD-3/PTPIP51 is a mitochondrial protein that tethers mitochondria to the endoplasmic reticulum. C. elegans RMD-2, 3, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0deead668961f69eccd3eec37fa4c16a
https://pubmed.ncbi.nlm.nih.gov/34296068
https://pubmed.ncbi.nlm.nih.gov/34296068
Autor:
Sabine A. H. Hoffmeister-Ullerich, Michael R. Kreutz, Laura Ruschkies, Jessica E. M. Dunleavy, Melanie Richter, Monika S. Brill, Thomas Misgeld, Franco L. Lombino, Edda Thies, Michael Frotscher, André T. Lopes, Torben J. Hausrat, David Lutz, Froylan Calderon de Anda, Mary Muhia, Francis J. McNally, Jeffrey Lopez-Rojas, Irm Hermans-Borgmeyer, Matthias Kneussel
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports
Scientific reports, 9:15940
Scientific reports, vol 9, iss 1
Scientific Reports
Scientific reports, 9:15940
Scientific reports, vol 9, iss 1
Microtubule severing regulates cytoskeletal rearrangement underlying various cellular functions. Katanin, a heterodimer, consisting of catalytic (p60) and regulatory (p80) subunits severs dynamic microtubules to modulate several stages of cell divisi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::166efaa6b8e3f7367fa7a47152ee290b
http://link.springer.com/article/10.1038/s41598-019-52367-3
http://link.springer.com/article/10.1038/s41598-019-52367-3