Zobrazeno 1 - 10
of 620
pro vyhledávání: '"Francis J Doyle"'
Autor:
Lindsey S Brown, Francis J Doyle
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 11, p e1008459 (2020)
The molecular circadian clock is driven by interlocked transcriptional-translational feedback loops, producing oscillations in the expressions of genes and proteins to coordinate the timing of biological processes throughout the body. Modeling this s
Externí odkaz:
https://doaj.org/article/c8e311242ab04c1f81a3cbd81cf0edaf
Autor:
Synthia H Mellon, F Saverio Bersani, Daniel Lindqvist, Rasha Hammamieh, Duncan Donohue, Kelsey Dean, Marti Jett, Rachel Yehuda, Janine Flory, Victor I Reus, Linda M Bierer, Iouri Makotkine, Duna Abu Amara, Clare Henn Haase, Michelle Coy, Francis J Doyle, Charles Marmar, Owen M Wolkowitz
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0213839 (2019)
Posttraumatic stress disorder (PTSD) is associated with impaired major domains of psychology and behavior. Individuals with PTSD also have increased co-morbidity with several serious medical conditions, including autoimmune diseases, cardiovascular d
Externí odkaz:
https://doaj.org/article/7a92b8e5847042428eb3305e3034fc25
Autor:
Peter C St John, Francis J Doyle
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 11, p e1004451 (2015)
Stochastic noise at the cellular level has been shown to play a fundamental role in circadian oscillations, influencing how groups of cells entrain to external cues and likely serving as the mechanism by which cell-autonomous rhythms are generated. D
Externí odkaz:
https://doaj.org/article/f30b95f91c364e878399b4c91da95cc9
Autor:
Zachary N. Blalock, Gwyneth W. Y Wu, Daniel Lindqvist, Caroline Trumpff, Janine D. Flory, Jue Lin, Victor I. Reus, Ryan Rampersaud, Rasha Hammamieh, Aarti Gautam, SBPBC, Francis J. Doyle, Charles R. Marmar, Marti Jett, Rachel Yehuda, Owen M. Wolkowitz, Synthia H. Mellon
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Circulating cell-free mitochondrial DNA (ccf-mtDNA) is a biomarker of cellular injury or cellular stress and is a potential novel biomarker of psychological stress and of various brain, somatic, and psychiatric disorders. No studies have yet
Externí odkaz:
https://doaj.org/article/462b504a442545f2add418e35eab0665
Autor:
Maria Rodriguez-Fernandez, Benyamin Grosman, Theresa M Yuraszeck, Bryan G Helwig, Lisa R Leon, Francis J Doyle
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e73393 (2013)
Heat stroke (HS) is a life-threatening illness induced by prolonged exposure to a hot environment that causes central nervous system abnormalities and severe hyperthermia. Current data suggest that the pathophysiological responses to heat stroke may
Externí odkaz:
https://doaj.org/article/78be039ac5cf43a38f70e1ff91249a62
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 2, p e1002379 (2012)
Cortisol, secreted in the adrenal cortex in response to stress, is an informative biomarker that distinguishes anxiety disorders such as major depression and post-traumatic stress disorder (PTSD) from normal subjects. Yehuda et al. proposed a hypothe
Externí odkaz:
https://doaj.org/article/c8a34303b0734ec9960ded5e50fd31ad
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 11, p e1002787 (2012)
The mammalian suprachiasmatic nuclei (SCN) contain thousands of neurons capable of generating near 24-h rhythms. When isolated from their network, SCN neurons exhibit a range of oscillatory phenotypes: sustained or damping oscillations, or arrhythmic
Externí odkaz:
https://doaj.org/article/31954a25e23e4f2aa539b464b50428ab
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e53130 (2012)
Pancreatic β-cell dysfunction is a diagnostic criterion of Type 2 diabetes and includes defects in glucose transport and insulin secretion. In healthy individuals, β-cells maintain plasma glucose concentrations within a narrow range in concert with
Externí odkaz:
https://doaj.org/article/6a43ad1c9e3942bbb05b920e7b2619c8
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42958 (2012)
Physiological and psychological stresses cause anxiety disorders such as depression and post-traumatic stress disorder (PTSD) and induce drastic changes at a molecular level in the brain. To counteract this stress, the heat-shock protein (HSP) networ
Externí odkaz:
https://doaj.org/article/7c47ff776d914058b6665cd020032d3b
Autor:
Theresa M Yuraszeck, Pierre Neveu, Maria Rodriguez-Fernandez, Anne Robinson, Kenneth S Kosik, Francis J Doyle
Publikováno v:
PLoS Computational Biology, Vol 6, Iss 11, p e1000997 (2010)
The multifactorial nature of disease motivates the use of systems-level analyses to understand their pathology. We used a systems biology approach to study tau aggregation, one of the hallmark features of Alzheimer's disease. A mathematical model was
Externí odkaz:
https://doaj.org/article/99a8da51ecab4091a0cf5aec9f6e3ee9