Zobrazeno 1 - 10
of 510
pro vyhledávání: '"Francis J Castellino"'
Autor:
Jonathan J. Molina, Kurt N. Kohler, Christopher Gager, Marissa J. Andersen, Ellsa Wongso, Elizabeth R. Lucas, Andrew Paik, Wei Xu, Deborah L. Donahue, Karla Bergeron, Aleksandra Klim, Michael G. Caparon, Scott J. Hultgren, Alana Desai, Victoria A. Ploplis, Matthew J. Flick, Francis J. Castellino, Ana L. Flores-Mireles
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Catheter-associated urinary tract infections (CAUTIs) are amongst the most common nosocomial infections worldwide and are difficult to treat partly due to development of multidrug-resistance from CAUTI-related pathogens. Importantly, CAUTI o
Externí odkaz:
https://doaj.org/article/3cbe7c971bf8491cb4d5b2b0b02ebda0
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0122840 (2015)
The neuroprotective activity of conantokin-G (con-G), a naturally occurring antagonist of N-methyl-D-aspartate receptors (NMDAR), was neurologically and histologically compared in the core and peri-infarct regions after ischemia/reperfusion brain inj
Externí odkaz:
https://doaj.org/article/9c660c43f1a04d79bbd6c67854766445
Autor:
Kamlesh K Gupta, Deborah L Donahue, Mayra J Sandoval-Cooper, Francis J Castellino, Victoria A Ploplis
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120728 (2015)
Sepsis-induced acute kidney injury (AKI) contributes to the high mortality and morbidity in patients. Although the pathogenesis of AKI during sepsis is poorly understood, it is well accepted that plasminogen activator inhibitor-1 (PAI-1) and vitronec
Externí odkaz:
https://doaj.org/article/2ebb137a2bcc41899be7cf91e2bfd9aa
Autor:
Jeffrey A Mayfield, Zhong Liang, Garima Agrahari, Shaun W Lee, Deborah L Donahue, Victoria A Ploplis, Francis J Castellino
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100698 (2014)
The cluster of virulence sensor (CovS)/responder (CovR) two-component operon (CovRS) regulates ∼15% of the genes of the Group A Streptococcal pyogenes (GAS) genome. Bacterial clones containing inactivating mutations in the covS gene have been isola
Externí odkaz:
https://doaj.org/article/34ad268c760145c9bb8b3c83fd5e2b3d
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 11 (2024)
Human plasminogen (PLG), the zymogen of the fibrinolytic protease, plasmin, is a polymorphic protein with two widely distributed codominant alleles, PLG/Asp453 and PLG/Asn453. About 15 other missense or non-synonymous single nucleotide polymorphisms
Externí odkaz:
https://doaj.org/article/07cce74d2c0f4e3ead298489121629fe
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e81405 (2013)
Three members of a family of small neurotoxic peptides from the venom of Conus parius, conantokins (Con) Pr1, Pr2, and Pr3, function as antagonists of N-methyl-D-aspartate receptors (NMDAR). We report structural characterizations of these synthetic p
Externí odkaz:
https://doaj.org/article/242d700ab10c4b8fa33b63aa9acd145b
Autor:
Martina L Sanderson-Smith, Yueling Zhang, Diane Ly, Deborah Donahue, Andrew Hollands, Victor Nizet, Marie Ranson, Victoria A Ploplis, Mark J Walker, Francis J Castellino
Publikováno v:
PLoS Pathogens, Vol 9, Iss 7, p e1003469 (2013)
Recruitment of the serine protease plasmin is central to the pathogenesis of many bacterial species, including Group A streptococcus (GAS), a leading cause of morbidity and mortality globally. A key process in invasive GAS disease is the ability to a
Externí odkaz:
https://doaj.org/article/fca5dc76a6ce464cbcffb989cb933e88
Autor:
Francis J Castellino, Zhong Liang, Patrick K Davis, Rashna D Balsara, Harsha Musunuru, Deborah L Donahue, Denise L Smith, Mayra J Sandoval-Cooper, Victoria A Ploplis, Mark Walsh
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52878 (2012)
To delineate the critical features of platelets required for formation and stability of thrombi, thromboelastography and platelet aggregation measurements were employed on whole blood of normal patients and of those with Bernard-Soulier Syndrome (BSS
Externí odkaz:
https://doaj.org/article/39cdca1cd69d4c199bd8fa80aa341c6d
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e25725 (2011)
Matrix metalloproteinase 7 (MMP7), a metallohydrolase involved in the development of several cancers, is downregulated in the Apc(Min/+) colon cancer mouse model following sulindac treatment. To determine whether this effect is relevant to the human
Externí odkaz:
https://doaj.org/article/6fc241cda55c4c6c8c355248fdd57f63
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9070 (2010)
Fas, a member of the tumor necrosis family, is responsible for initiating the apoptotic pathway when bound to its ligand, Fas-L. Defects in the Fas-mediated apoptotic pathway have been reported in colorectal cancer.In the present study, a variant of
Externí odkaz:
https://doaj.org/article/e0c6d1974186437fa5c56eda4e7929b8