Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Francis Grafton"'
Autor:
Sara Ranjbarvaziri, Aliya Zeng, Iris Wu, Amara Greer-Short, Farshad Farshidfar, Ana Budan, Emma Xu, Reva Shenwai, Matthew Kozubov, Cindy Li, Melissa Van Pell, Francis Grafton, Charles E MacKay, Xiaomei Song, James R Priest, Gretchen Argast, Mohammad A. Mandegar, Timothy Hoey, Jin Yang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-2 (2024)
Externí odkaz:
https://doaj.org/article/665b649400904d3780546ebb20c2a05d
Autor:
Sara Ranjbarvaziri, Aliya Zeng, Iris Wu, Amara Greer-Short, Farshad Farshidfar, Ana Budan, Emma Xu, Reva Shenwai, Matthew Kozubov, Cindy Li, Melissa Van Pell, Francis Grafton, Charles E MacKay, Xiaomei Song, James R Priest, Gretchen Argast, Mohammad A. Mandegar, Timothy Hoey, Jin Yang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Heart failure with preserved ejection fraction (HFpEF) poses therapeutic challenges due to the limited treatment options. Building upon our previous research that demonstrates the efficacy of histone deacetylase 6 (HDAC6) inhibition in a gen
Externí odkaz:
https://doaj.org/article/9658610d4ff04dbaabe514860e2f248f
Autor:
Francis Grafton, Jaclyn Ho, Sara Ranjbarvaziri, Farshad Farshidfar, Anastasiia Budan, Stephanie Steltzer, Mahnaz Maddah, Kevin E Loewke, Kristina Green, Snahel Patel, Tim Hoey, Mohammad Ali Mandegar
Publikováno v:
eLife, Vol 10 (2021)
Drug-induced cardiotoxicity and hepatotoxicity are major causes of drug attrition. To decrease late-stage drug attrition, pharmaceutical and biotechnology industries need to establish biologically relevant models that use phenotypic screening to dete
Externí odkaz:
https://doaj.org/article/ac40721906f04a0b8947457bd4ad3670
Autor:
Jin Yang, Francis Grafton, Sara Ranjbarvaziri, Ana Budan, Farshad Farshidfar, Marie Cho, Emma Xu, Jaclyn Ho, Mahnaz Maddah, Kevin E. Loewke, Julio Medina, David Sperandio, Snahel Patel, Tim Hoey, Mohammad A. Mandegar
Publikováno v:
Science translational medicine. 14(652)
Dilated cardiomyopathy (DCM) is characterized by reduced cardiac output, as well as thinning and enlargement of left ventricular chambers. These characteristics eventually lead to heart failure. Current standards of care do not target the underlying
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb087098594330648b8ab9ba7ac091b6
https://pubmed.ncbi.nlm.nih.gov/35896800
https://pubmed.ncbi.nlm.nih.gov/35896800
Autor:
Kristina Green, Farshad Farshidfar, Sara Ranjbarvaziri, Patel Snahel, Jaclyn J. Ho, Mahnaz Maddah, Mohammad A. Mandegar, Tim Hoey, Stephanie Steltzer, Francis Grafton, Anastasiia Budan, Kevin E. Loewke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a288d2a8add948bff2c2e180b7a97cfd
https://doi.org/10.7554/elife.68714.sa2
https://doi.org/10.7554/elife.68714.sa2
Autor:
Farshad Farshidfar, Mahnaz Maddah, Mohammad A. Mandegar, Sara Ranjbarvaziri, Patel Snahel, Kristina Green, Jaclyn J. Ho, Francis Grafton, Stephanie Steltzer, Anastasiia Budan, Kevin E. Loewke, Tim Hoey
Drug-induced cardiotoxicity and hepatotoxicity are major causes of drug attrition. To decrease late-stage drug attrition, pharmaceutical and biotechnology industries need to establish biologically relevant models that use phenotypic screening to pred
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41bf660a8d4a8ac70dfa7c51a873d243
https://doi.org/10.1101/2021.03.23.436666
https://doi.org/10.1101/2021.03.23.436666
Publikováno v:
McGill Science Undergraduate Research Journal. 11:22-27
Background: The α-9/10 nicotinic acetylcholine receptor is known to be the primary channel through which both vestibular and auditory efferents mediate the inhibition of their respective peripheral hair cells and afferents. With respect to the audit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a7abd9291e645a383d42f22b0e39683
https://doi.org/10.26443/msurj.v11i1.164
https://doi.org/10.26443/msurj.v11i1.164
Autor:
Keri Dame, Kevin E. Loewke, Alexandre J.S. Ribeiro, Francis Grafton, Mahnaz Maddah, Mohammad A. Mandegar
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 105:106895
Cardiac and hepatic toxicity result from induced disruption of the functioning of cardiomyocytes and hepatocytes, respectively, which is tightly related to the organization of their subcellular structures. Cellular structure can be analyzed from micr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::073a5ebdad1af1f5f160d984d4a74e50
https://doi.org/10.1016/j.vascn.2020.106895
https://doi.org/10.1016/j.vascn.2020.106895