Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Francis G Fang"'
Autor:
Kunihiko Kanatsu, Yoshinori Takahashi, Tetsuya Sakaguchi, Dae-Shik Kim, Miki Murota, Mingde Shan, Kazuki Fukami, Wataru Itano, Kenji Kikuta, Hikaru Yoshimura, Toshiki Kurokawa, Yuko Nagayama, Rena Ishikawa, Ryo Dairiki, Zhi Zhou, Kristen Sanders, Jacob Stupalski, So Yasui, Diana Liu, Farid Benayoud, Hui Fang, Enxuan Jing, Makoto Ogo, Francis G. Fang, John Wang, Hyeong-wook Choi
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 36, Iss 1, Pp 102404- (2025)
Antisense oligonucleotides (ASOs) are an important class of therapeutics to treat genetic diseases, and expansion of this modality to neurodegenerative disorders has been an active area of research. To realize chronic administration of ASO therapeuti
Externí odkaz:
https://doaj.org/article/48fa025010654763a422d4a52be32434
Structural basis of malaria parasite phenylalanine tRNA-synthetase inhibition by bicyclic azetidines
Autor:
Manmohan Sharma, Nipun Malhotra, Manickam Yogavel, Karl Harlos, Bruno Melillo, Eamon Comer, Arthur Gonse, Suhel Parvez, Branko Mitasev, Francis G. Fang, Stuart L. Schreiber, Amit Sharma
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Bicyclic azetidine inhibitors are promising antimalarials that target the Plasmodium cytosolic phenylalanine tRNAsynthetase (cFRS). Here, Sharma et al. provide the biochemical and structural basis of its mechanism using co-crystal structure of PvcFRS
Externí odkaz:
https://doaj.org/article/96b3e407ffe647c5b54ac432fe843d79
Autor:
Takashi Niwa, Tsuyoshi Tahara, Charles E. Chase, Francis G. Fang, Takayoshi Nakaoka, Satsuki Irie, Emi Hayashinaka, Yasuhiro Wada, Hidefumi Mukai, Kenkichi Masutomi, Yasuyoshi Watanabe, Yilong Cui, Takamitsu Hosoya
Publikováno v:
Bulletin of the Chemical Society of Japan. 96:283-290
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::574aaacbd2a91d1bbc32c562ecac31a1
https://doi.org/10.1246/bcsj.20220335
https://doi.org/10.1246/bcsj.20220335
Autor:
Xingfeng Bao, Francis G. Fang, Nadeem Sarwar, Janna Hutz, John Wang, Mark Matijevic, Yu Chen, Thomas A. Noland, Atsushi Endo, Dae-Shik Kim, David Verbel, Noel Taylor, Renee Hukkanen, Huilan Yao, Karen Tendyke, Jiayi Wu, Chi Zhang, Vaishali Dixit, Shannon McGrath, Dinesh Chandra, Kuan-Chun Huang
Stimulator of interferon genes (STING) is an innate immune receptor activated by natural or synthetic agonists to elicit antitumoral immune response via type I IFNs and other inflammatory cytokines. Bacillus Calmette-Guerin (BCG) is the standard of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f3d9ee7ebb8731980048e5b88caf15a
https://doi.org/10.1158/1535-7163.c.6543267
https://doi.org/10.1158/1535-7163.c.6543267
Autor:
Xingfeng Bao, Francis G. Fang, Nadeem Sarwar, Janna Hutz, John Wang, Mark Matijevic, Yu Chen, Thomas A. Noland, Atsushi Endo, Dae-Shik Kim, David Verbel, Noel Taylor, Renee Hukkanen, Huilan Yao, Karen Tendyke, Jiayi Wu, Chi Zhang, Vaishali Dixit, Shannon McGrath, Dinesh Chandra, Kuan-Chun Huang
Supplementary Table from Pharmacologic Activation of STING in the Bladder Induces Potent Antitumor Immunity in Non–Muscle Invasive Murine Bladder Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f4982a5678c9cb618ec50a450ed0964
https://doi.org/10.1158/1535-7163.22522050
https://doi.org/10.1158/1535-7163.22522050
Autor:
Xingfeng Bao, Francis G. Fang, Nadeem Sarwar, Janna Hutz, John Wang, Mark Matijevic, Yu Chen, Thomas A. Noland, Atsushi Endo, Dae-Shik Kim, David Verbel, Noel Taylor, Renee Hukkanen, Huilan Yao, Karen Tendyke, Jiayi Wu, Chi Zhang, Vaishali Dixit, Shannon McGrath, Dinesh Chandra, Kuan-Chun Huang
Supplementary Figure from Pharmacologic Activation of STING in the Bladder Induces Potent Antitumor Immunity in Non–Muscle Invasive Murine Bladder Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d5ae3b428e39e00eb21a6ffcbdd5d39
https://doi.org/10.1158/1535-7163.22522053
https://doi.org/10.1158/1535-7163.22522053
Autor:
Francis G. Fang, Fabian Gusovsky, Vijay Kalla, Venkata Sasidhar Balla, Dixit Girish, Chiranjeevi Terli, Branko Mitasev, Ravi Kumar Talabhakthula, Venugopalarao Vikram, Srinivasa Rao Sugandham, Bruno Melillo, Anand Vaddi, Jiong Yang, Stuart L. Schreiber, Srikanth Bathula, Pavan Kumar Rayaprolu, Anil Shahaji Khile, Masaharu Gotoda
Publikováno v:
Organic Process Research & Development. 26:817-831
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::555e4ce3e36547f4ee636a2b8a25c676
https://doi.org/10.1021/acs.oprd.1c00225
https://doi.org/10.1021/acs.oprd.1c00225
Autor:
Farid Benayoud, Masayuki Omori, Yuichi Suzuki, Arani Chanda, Kazunori Wakasugi, Yuzo Watanabe, Akio Kayano, Paschalis Dimopoulos, Yoichi Kita, Kunitoshi Takeda, Toshihiko Kaneko, Mitsuo Nagai, Noboru Yamamoto, Takafumi Motoki, Kazuhiro Yoshizawa, Christopher Neil Farthing, Lily Lu, Matthew J. Schnaderbeck, Khan Afzal, Tasuku Ishida, Huiming Zhang, Mamoru Takaishi, Markus Bracke, Branko Mitasev, Dae-Shik Kim, Francis G. Fang, Adrian Hall
Publikováno v:
Organic Process Research & Development. 26:804-816
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb5e8d3db93d6da5adb84ced4755f7b9
https://doi.org/10.1021/acs.oprd.1c00223
https://doi.org/10.1021/acs.oprd.1c00223
Autor:
Kuan-Chun Huang, Dinesh Chandra, Shannon McGrath, Vaishali Dixit, Chi Zhang, Jiayi Wu, Karen Tendyke, Huilan Yao, Renee Hukkanen, Noel Taylor, David Verbel, Dae-Shik Kim, Atsushi Endo, Thomas A. Noland, Yu Chen, Mark Matijevic, John Wang, Janna Hutz, Nadeem Sarwar, Francis G Fang, Xingfeng Bao
Publikováno v:
Molecular Cancer Therapeutics. 22:551-551
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec2b09b30299a732223f4eacba70bcea
https://doi.org/10.1158/1535-7163.mct-23-0121
https://doi.org/10.1158/1535-7163.mct-23-0121
Autor:
Kristen Sanders, Janna Hutz, Hyeong-Wook Choi, Steven Mathieu, Dae-Shik Kim, Yongchun Shen, Thomas Noland, Yu Chen, Christy Ingersoll, Utpal Majumder, Xiaojie Zhu, Xingfeng Bao, Jiayi Wu, Karen TenDyke, Atsushi Endo, Nadeem Sarwar, So Yasui, Kuan-Chun Huang, Francis G. Fang, John Wang, Kara A. Loiacono, Ming-Hong Hao
Publikováno v:
ChemMedChem. 16:1741-1744
A strategy for creating potent and pan-genotypic stimulator of interferon genes (STING) agonists is described. Locking a bioactive U-shaped conformation of cyclic dinucleotides by introducing a transannular macrocyclic bridge between the nucleic acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::004795c53b9e23729fc448b3023672c0
https://doi.org/10.1002/cmdc.202100068
https://doi.org/10.1002/cmdc.202100068