Zobrazeno 1 - 10
of 686
pro vyhledávání: '"Francis G, Spinale"'
Autor:
Stephanie L Samani, Shayne C Barlow, Lisa A Freeburg, Traci L Jones, Marlee Poole, Mark A Sarzynski, Michael R Zile, Tarek Shazly, Francis G Spinale
Publikováno v:
PLoS ONE, Vol 19, Iss 2, p e0292243 (2024)
BackgroundStandardized exercise protocols have been shown to improve overall cardiovascular fitness, but direct effects on left ventricular (LV) function, particularly diastolic function and relation to post-transcriptional molecular pathways (microR
Externí odkaz:
https://doaj.org/article/f0f0cf33b3ec4f5286355ca0b5c3e294
Publikováno v:
BMC Medical Informatics and Decision Making, Vol 22, Iss 1, Pp 1-10 (2022)
Abstract Background Cardiac Resynchronization Therapy (CRT) is a widely used, device-based therapy for patients with left ventricle (LV) failure. Unfortunately, many patients do not benefit from CRT, so there is potential value in identifying this gr
Externí odkaz:
https://doaj.org/article/47bcf85edb0c4e7591653b2230d951bd
Publikováno v:
JTCVS Open, Vol 10, Iss , Pp 185-194 (2022)
Externí odkaz:
https://doaj.org/article/a150a816c0614128a02063cac0a1585c
Autor:
Patrick Badertscher, MD, David Gregg, MD, Catalin F. Baicu, PhD, Viswanathan Ramakrishnan, PhD, Francis G. Spinale, MD, PhD, Michael R. Zile, MD, Michael R. Gold, MD, PhD, FHRS
Publikováno v:
Heart Rhythm O2, Vol 2, Iss 1, Pp 37-45 (2021)
Background: Atrial fibrillation (AF) is less common in African Americans (AA) than Caucasians (C) despite a higher prevalence of risk factors such as hypertension (HTN). Objective: Test the hypothesis that differences in extracellular matrix (ECM) be
Externí odkaz:
https://doaj.org/article/f2d76ac15469419b9545ff07f003b349
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
There is a critical need for interventions to control the development and remodeling of scar tissue after myocardial infarction. A significant hurdle to fibrosis-related therapy is presented by the complex spatial needs of the infarcted ventricle, na
Externí odkaz:
https://doaj.org/article/eee16b33348c4d9ea72f8102f79b8d37
Autor:
Olga H. Toro-Salazar, Ji Hyun Lee, Kia N. Zellars, Paige E. Perreault, Kathryn C. Mason, Zhu Wang, Kan N. Hor, Eileen Gillan, Caroline J. Zeiss, Daniel M. Gatti, Brooke T. Davey, Shelby Kutty, Bruce T. Liang, Francis G. Spinale
Publikováno v:
Cardio-Oncology, Vol 4, Iss 1, Pp 1-11 (2018)
Abstract Background Anthracycline induced cardiomyopathy is a major cause of mortality and morbidity among pediatric cancer survivors. It has been postulated that oxidative stress induction and inflammation may play a role in the pathogenesis of this
Externí odkaz:
https://doaj.org/article/81eee6c0ac974fc38f9cb55f49d53ef9
Autor:
Stephanie L. Thorn, James A. Shuman, Mitchel R. Stacy, Brendan P. Purcell, Heather Doviak, Jason A. Burdick, Francis G. Spinale, Albert J. Sinusas
Publikováno v:
Journal of Cardiovascular Translational Research. 16:155-165
Autor:
Mitchel R. Stacy, Ben A. Lin, Stephanie L. Thorn, David C. Lobb, Mark W. Maxfield, Craig Novack, Kia N. Zellars, Lisa Freeburg, Joseph G. Akar, Albert J. Sinusas, Francis G. Spinale
Publikováno v:
Heart Rhythm
BACKGROUND: Left ventricular (LV) remodeling following a myocardial infarction (MI) is associated with new onset atrial fibrillation (AF). LV remodeling post-MI is characterized by regional changes in matrix metalloproteinases (MMPs) and tissue inhib
Ensemble machine learning model identifies patients with HFpEF from matrix-related plasma biomarkers
Autor:
Michael Ward, Amirreza Yeganegi, Catalin F. Baicu, Amy D. Bradshaw, Francis G. Spinale, Michael R. Zile, William J. Richardson
Publikováno v:
Am J Physiol Heart Circ Physiol
Arterial hypertension can lead to structural changes within the heart including left ventricular hypertrophy (LVH) and eventually heart failure with preserved ejection fraction (HFpEF). The initial diagnosis of HFpEF is costly and generally based on
Autor:
Jonathan A. Kirk, Zamaneh Kassiri, Edward B. Thorp, Keith R. Brunt, Crystal M. Ripplinger, Steven P. Jones, Kristine Y. DeLeon-Pennell, Ganesh V. Halade, Petra Kleinbongard, Lisandra E. de Castro Brás, Rebecca H. Ritchie, Merry L. Lindsey, Nikolaos G. Frangogiannis, John W. Calvert, Dominic P. Del Re, Francis G. Spinale, Stefan Frantz, Richard J. Gumina
Publikováno v:
Am J Physiol Heart Circ Physiol
Despite significant improvements in reperfusion strategies, acute coronary syndromes all too often culminate in a myocardial infarction (MI). The consequent MI can, in turn, lead to remodeling of the left ventricle (LV), the development of LV dysfunc