UNBS5162, a Novel Naphthalimide That Decreases CXCL Chemokine Expression in Experimental Prostate Cancers

Autor: Tatjana Mijatovic, Tina Mahieu, Céline Bruyère, Nancy De Nève, Janique Dewelle, Gentiane Simon, Mischaël J.M. Dehoux, Ellen van der Aar, Benjamin Haibe-Kains, Gianluca Bontempi, Christine Decaestecker, Eric Van Quaquebeke, Francis Darro, Robert Kiss

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 10, Iss 6, Pp 573-586 (2008)

Several naphthalimides have been evaluated clinically as potential anticancer agents. UNBS3157, a naphthalimide that belongs to the same class as amonafide, was designed to avoid the specific activating metabolism that induces amonafide’s hematotox

Externí odkaz: https://doaj.org/article/4107d46edf0f43789479a01f83b30729

Cardenolide-Induced Lysosomal Membrane Permeabilization Demonstrates Therapeutic Benefits in Experimental Human Non-Small Cell Lung Cancers

Autor: Tatjana Mijatovic, Véronique Mathieu, Jean-François Gaussin, Nancy De Néve, Fabrice Ribaucour, Eric Van Quaquebeke, Patrick Dumont, Francis Darro, Robert Kiss

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 8, Iss 5, Pp 402-412 (2006)

Non-small cell lung cancers (NSCLCs) are the leading cause of cancer deaths in most developed countries. Targeting heat shock protein 70 (Hsp70) expression and function, together with the induction of lysosomal membrane permeabilization (LMP), could

Externí odkaz: https://doaj.org/article/223d995ff71b41e3ae603e20fbdf5d44

Cardiotonic steroids on the road to anti-cancer therapy

Autor: Eric Van Quaquebeke, Bruno Delest, Tatjana Mijatovic, Francis Darro, Robert Kiss, Olivier Debeir

Publikováno v: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 1776:32-57

The sodium pump, Na(+)/K(+)-ATPase, could be an important target for the development of anti-cancer drugs as it serves as a versatile signal transducer, it is a key player in cell adhesion and its aberrant expression and activity are implicated in th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86c8c459785793b2db750055930512d0
https://doi.org/10.1016/j.bbcan.2007.06.002

The α1 subunit of the sodium pump could represent a novel target to combat non-small cell lung cancers

Autor: Robert Kiss, Isabelle Roland, Gustavo Blanco, F. Van Vynckt, Anne Mathieu, E. Van Quaquebeke, B Nilsson, Tatjana Mijatovic, Francis Darro, Vincenzo Facchini

Publikováno v: The Journal of Pathology. 212:170-179

With an overall 5 year survival rate as low as 15% for non-small cell lung cancer (NSCLC), even with surgical intervention and the use of newer molecules in adjuvant chemotherapy, there is an urgent need for new biological targets and associated nove

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::578f12f062564312f5a622e81c1ff805
https://doi.org/10.1002/path.2172

Cardenolide-Induced Lysosomal Membrane Permeabilization Demonstrates Therapeutic Benefits in Experimental Human Non-Small Cell Lung Cancers

Autor: Fabrice Ribaucour, Véronique Mathieu, Eric Van Quaquebeke, Tatjana Mijatovic, Jean-François Gaussin, Patrick Dumont, Francis Darro, Robert Kiss, Nancy De Nève

Publikováno v: Neoplasia (New York, N.Y.), 8 (5
Neoplasia: An International Journal for Oncology Research, Vol 8, Iss 5, Pp 402-412 (2006)
NeoPlasia : an international journal of oncology research, no. 8, p. 402-412 (2006)

Non-small cell lung cancers (NSCLCs) are the leading cause of cancer deaths in most developed countries. Targeting heat shock protein 70 (Hsp70) expression and function, together with the induction of lysosomal membrane permeabilization (LMP), could

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a165ed060154ef36e2a1256ecabe73d