Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Francis C. Chao"'
Publikováno v:
Thrombosis and Haemostasis. 32:216-231
SummaryThe effects of varying concentrations of platelets, fibrinogen and thrombin on platelet aggregation and on fibrin clotting were investigated. The results indicated that a threshold thrombin to platelet concentration ratio may be required to ca
Publikováno v:
Blood. 69:479-485
Sixty-eight patients with malignant disease were divided into two groups based on the results of the platelet antithrombin test (PAT). The normal group had a PAT clotting time ranging from 21.4 to 29.8 seconds, which was equivalent to 25% to 65% inac
Publikováno v:
Thrombosis and Haemostasis. 34:115-126
SummaryAntithrombin activity has been identified in intact washed human platelets. An apparent activity was demonstrated at platelet concentrations above 0.31 × 109/ml, when platelet suspensions were incubated with 2.0 NIH units/ml of thrombin. Neit
Autor:
Francis C. Chao, Dianne M. Kenney
Publikováno v:
Journal of Cellular Physiology. 96:43-52
The effects of the antimicrotubular drugs colchicine and vinblastine on the blood platelet release reaction were studied by measuring release of 14C-5-hydroxytryptamine (14C-5-HT, release I) and β-glucuronidase (release II) from gel-filtered human p
Publikováno v:
Blood. 55:187-194
Treatment of platelets (10(9) cells/ml) with thrombin (1 U/ml) resulted in rapid disappearance of fibrinogen from the system as measured by the tanned red cell hemagglutination inhibition immunoassay (TRCHII). Plasmin digestion of individual pellet a
Publikováno v:
Blood. 67:555-558
Essential thrombocythemia is a myeloproliferative disorder characterized by frequent bleeding and thrombotic complications. On a molecular level, two abnormalities of platelet thrombospondin have been identified: abnormal glycosylation of the intact
Autor:
Francis C. Chao, Hanspeter Honegger, Dianne M. Kenney, Omar Fleischaker, Linda Hewitt, James L. Tullis
Publikováno v:
Cancer. 48:1177-1182
Analysis of fresh surgical specimens of normal tissue and tumor tissue show a cellular antithrombin activity to be present in certain organs. In normal tissues it was noted chiefly in normal colon, testes, breast, and uterus. In malignant tissues it
Publikováno v:
Thrombosis and Haemostasis. 34:780-794
SummaryThe uptake and binding of antimitotic alkaloid colchicine has been demonstrated in washed preparations of human platelets. A silicone oil technique was adapted so that both uptake and binding of 14C-colchicine were examined in the same platele
Publikováno v:
Journal of Psychiatric Research. 16:163-171
Autor:
Dianne M. Kenney, Francis C. Chao
Publikováno v:
Journal of Cellular Physiology. 103:289-298
Cytoplasmic calcium levels are believed to be important in blood platelet activation. Upon activation, the discrete marginal microtubule band, which maintains the discoid shape of non-activated platelets, becomes disrupted. Present studies demonstrat