Zobrazeno 1 - 10
of 241
pro vyhledávání: '"Francis C. Szoka"'
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 7, Iss C, Pp 60-73 (2017)
New methods to produce large numbers of myeloid progenitor cells, precursors to macrophages (MΦs), by maintaining Hoxb8 transcription factor activity1 has reinvigorated interest in MΦ cell therapies. We generated Hoxb8-dependent myeloid progenitors
Externí odkaz:
https://doaj.org/article/32d287b13d874155a319d7df03cfac6a
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0215218 (2019)
Poor solute transport through the cartilage endplate (CEP) impairs disc nutrition and could be a key factor that limits the success of intradiscal biologic therapies. Here we demonstrate that treating the CEP with matrix metalloproteinase-8 (MMP-8) r
Externí odkaz:
https://doaj.org/article/2d73efca4a9845d7b36f8f8984bd4c6e
Autor:
Francis C. Szoka
Publikováno v:
Science translational medicine. 14(654)
PEGylated lipid protein immunogens delivered intranasally to mice and macaques drive production of IgG and IgA antibodies at other mucosal sites (Hartwell et al. ).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f95b4255b6af9c8030b81c61431f40b
https://pubmed.ncbi.nlm.nih.gov/35857825
https://pubmed.ncbi.nlm.nih.gov/35857825
Publikováno v:
Blood. 140:11557-11558
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b23686365a13fe25568c4ba78721103
https://doi.org/10.1182/blood-2022-168103
https://doi.org/10.1182/blood-2022-168103
Autor:
Linda T. Vo, P. Jonathan Li, Theodore L. Roth, Murad R. Mamedov, David N. Nguyen, Peixin Amy Chen, Eric Shifrut, Jeffrey A. Bluestone, Ryan Apathy, Alexander Marson, Francis C. Szoka, Jennifer M. Puck, Daniel B. Goodman, Victoria Tobin
Publikováno v:
Nature biotechnology
Nature biotechnology, vol 38, iss 1
Nature biotechnology, vol 38, iss 1
Versatile and precise genome modifications are needed to create a wider range of adoptive cellular therapies1-5. Here we report two improvements that increase the efficiency of CRISPR-Cas9-based genome editing in clinically relevant primary cell type
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edaff5425b66396abfa68d401206e96a
https://doi.org/10.1038/s41587-019-0325-6
https://doi.org/10.1038/s41587-019-0325-6
Autor:
Ayano Ueno, Kaori Igarashi, Huixia Li, Zhipeng Dai, Carlos H.G. Sponton, Tomoyoshi Soga, Momoko Yoneshiro, Qiang Wang, Zachary Brown, Takeshi Yoneshiro, Haruya Takahashi, Takamasa Ishikawa, Rachana N. Pradhan, Mito Kuroda, Kyeongkyu Kim, Olga Ilkayeva, Robert W. McGarrah, Michael T. McManus, Yann Deleye, Tsuyoshi Goto, Labros S. Sidossis, Vanille J. Greiner, Shingo Kajimura, Yong Chen, Maki Ohishi, Yasuo Oguri, Hiroko Maki, Phillip J. White, Francis C. Szoka, Maria Chondronikola, Mami Matsushita, Kazuki Tajima, Masayuki Saito, Teruo Kawada, Homa Majd, Kenji Ikeda
Publikováno v:
Nature, vol 572, iss 7771
Endocrinology
Endocrinology
Branched-chain amino acid (BCAA; valine, leucine and isoleucine) supplementation is often beneficial to energy expenditure; however, increased circulatinglevels of BCAA are linked to obesity and diabetes. The mechanisms of this paradox remain unclear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ac559a32ea08ae0a8f0a3b76e42d03c
https://doi.org/10.1038/s41586-019-1503-x
https://doi.org/10.1038/s41586-019-1503-x
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102566 (2014)
We explore a strategy to substantially increase the half-life of recombinant proteins by genetic fusion to FcIII, a 13-mer IgG-Fc domain binding peptide (IgGBP) originally identified by DeLano and co-workers at Genentech [DeLano WL, et al. (2000) Sci
Externí odkaz:
https://doaj.org/article/e516049d6443427daa8548bf20595ec6
Publikováno v:
BioTechniques, Vol 27, Iss 2, Pp 286-290 (1999)
Externí odkaz:
https://doaj.org/article/78ce1038a2644d929d0e4fa4ef788fcb
Autor:
Mei Li, Douglas Yasumura, Aye Aye K Ma, Michael T Matthes, Haidong Yang, Gregory Nielson, Yong Huang, Francis C Szoka, Matthew M Lavail, Marc I Diamond
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56026 (2013)
Huntington disease (HD) is an inherited neurodegenerative disease that affects multiple brain regions. It is caused by an expanded polyglutamine tract in huntingtin (Htt). The development of therapies for HD and other neurodegenerative diseases has b
Externí odkaz:
https://doaj.org/article/7e3484705d5c43ee9ae68c9aba56ed2f
Publikováno v:
Gene Therapy for Diseases of the Lung ISBN: 9781003064619
The delivery of nucleic acids for therapeutic purposes must surmount multiple cellular barriers that restrict efficient gene delivery. Manipulation of the biology of the cell and association of various effectors with the nucleic acid or utilization o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::326b31ac692881a96a0b2861b58dfaf9
https://doi.org/10.1201/9781003064619-11
https://doi.org/10.1201/9781003064619-11
