Zobrazeno 1 - 10
of 150
pro vyhledávání: '"Francis C Peterson"'
Autor:
Christian Berg, Michael J Wedemeyer, Motiejus Melynis, Roman R Schlimgen, Lasse H Hansen, Jon Våbenø, Francis C Peterson, Brian F Volkman, Mette M Rosenkilde, Hans R Lüttichau
Publikováno v:
PLoS Pathogens, Vol 18, Iss 3, p e1010355 (2022)
Human cytomegalovirus (HCMV) is a major pathogen in immunocompromised patients. The UL146 gene exists as 14 diverse genotypes among clinical isolates, which encode 14 different CXC chemokines. One genotype (vCXCL1GT1) is a known agonist for CXCR1 and
Externí odkaz:
https://doaj.org/article/b58f3e9f294b4bb682ffd33432ab9a5c
Autor:
Roman R. Schlimgen, Francis C. Peterson, Raimond Heukers, Martine J. Smit, John D. McCorvy, Brian F. Volkman
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract G protein-coupled receptors (GPCRs) are pivotal therapeutic targets, but their complex structure poses challenges for effective drug design. Nanobodies, or single-domain antibodies, have emerged as a promising therapeutic strategy to target
Externí odkaz:
https://doaj.org/article/52636f4e898c4c9caf197813d718a9df
Autor:
Andrew F Maule, David P Wright, Joshua J Weiner, Lanlan Han, Francis C Peterson, Brian F Volkman, Nicholas R Silvaggi, Andrew T Ulijasz
Publikováno v:
PLoS Pathogens, Vol 11, Iss 4, p e1004795 (2015)
Two-component signaling systems are ubiquitous in bacteria, Archaea and plants and play important roles in sensing and responding to environmental stimuli. To propagate a signaling response the typical system employs a sensory histidine kinase that p
Externí odkaz:
https://doaj.org/article/76130a7903044f98ac2797606428d74b
Autor:
Ting Xu, Anne Sophie Schou, Jarkko J. Lackman, Marina Barrio-Calvo, Lisa Verhallen, Christoffer Knak Goth, Benjamin Anderschou Holbech Jensen, Christopher T. Veldkamp, Brian F. Volkman, Francis C. Peterson, Gertrud Malene Hjortø
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 19, p 10854 (2024)
The chemokine receptors CCR1 and CCR5 display overlapping expression patterns and ligand dependency. Here we find that ligand activation of CCR5, not CCR1, is dependent on N-terminal receptor O-glycosylation. Release from O-glycosylation dependency i
Externí odkaz:
https://doaj.org/article/bd4632476ed246ffbad5143f98775b38
Autor:
Angela L. Zhou, Davin R. Jensen, Francis C. Peterson, Monica A. Thomas, Roman R. Schlimgen, Michael B. Dwinell, Brian C. Smith, Brian F. Volkman
Publikováno v:
SLAS Discovery, Vol 28, Iss 4, Pp 163-169 (2023)
The mucosal chemokine CCL28 is a promising target for immunotherapy drug development due to its elevated expression level in epithelial cells and critical role in creating and maintaining an immunosuppressive tumor microenvironment. Using sulfotyrosi
Externí odkaz:
https://doaj.org/article/cda8960ad51a44dcad7771ca3279a769
Autor:
Robin N. Witt, Kaileigh S. Nickel, John R. Binns, Alexander M. Gray, Alyssa M. Hintz, Noah F. Kofron, Steven F. Steigleder, Francis C. Peterson, Christopher T. Veldkamp
Publikováno v:
Biochemistry and Biophysics Reports, Vol 35, Iss , Pp 101524- (2023)
Chemokines are from a family of secreted cytokines that direct the trafficking of immune cells to coordinate immune responses. Chemokines are involved in numerous disease states, including responding to infections, autoimmune disorders, and cancer me
Externí odkaz:
https://doaj.org/article/b7fdc898e9404bb6b0c6597b58871729
Autor:
Deepak Parashar, Anjali Geethadevi, Donna McAllister, Johnathan Ebben, Francis C. Peterson, Davin R. Jensen, Erin Bishop, Sunila Pradeep, Brian F. Volkman, Michael B. Dwinell, Pradeep Chaluvally-Raghavan, Michael A. James
Publikováno v:
npj Precision Oncology, Vol 5, Iss 1, Pp 1-13 (2021)
Abstract Recurrence of therapy-resistant tumors is a principal problem in solid tumor oncology, particularly in ovarian cancer. Despite common complete responses to first line, platinum-based therapies, most women with ovarian cancer recur, and event
Externí odkaz:
https://doaj.org/article/c7efb85699a44039a124ea4253dbf709
Autor:
Holly N. Haver, Michael Wedemeyer, Erin Butcher, Francis C. Peterson, Brian F. Volkman, K. Matthew Scaglione
Publikováno v:
ACS Chemical Biology. 18:549-560
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a8827593aec0c7fb25939276a6285fc
https://doi.org/10.1021/acschembio.2c00893
https://doi.org/10.1021/acschembio.2c00893
Autor:
Emma Probst Brandum, Astrid Sissel Jørgensen, Marina Barrio Calvo, Katja Spiess, Francis C. Peterson, Zhang Yang, Brian F. Volkman, Christopher T. Veldkamp, Mette Marie Rosenkilde, Christoffer Knak Goth, Gertrud Malene Hjortø
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1397 (2022)
The chemokine receptor CCR7 and its ligands CCL19 and CCL21 regulate the lymph node homing of dendritic cells and naïve T-cells and the following induction of a motile DC-T cell priming state. Although CCL19 and CCL21 bind CCR7 with similar affiniti
Externí odkaz:
https://doaj.org/article/3e939e5d28bb4a66b830aab23d241528
Autor:
David E. Kim, Davin R. Jensen, David Feldman, Doug Tischer, Ayesha Saleem, Cameron M. Chow, Xinting Li, Lauren Carter, Lukas Milles, Hannah Nguyen, Alex Kang, Asim K. Bera, Francis C. Peterson, Brian F. Volkman, Sergey Ovchinnikov, David Baker
Publikováno v:
Proceedings of the National Academy of Sciences. 120
This dataset contains the supplementary materialsfor "De novo design of small beta barrel proteins" Datasets. All dataset_SX.tar.gz files extract into a directory named data_archive. Dataset S1 (dataset_S1.tar.gz). Contains designs, input files (incl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05ceedf726d217ed0e0b564435350c65
https://doi.org/10.1073/pnas.2207974120
https://doi.org/10.1073/pnas.2207974120