Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Francis C, Luca"'
Autor:
Paulo F. Santos, Beatriz Fazendeiro, Francis C. Luca, António Francisco Ambrósio, Hélène Léger
Publikováno v:
European Journal of Cell Biology, Vol 102, Iss 2, Pp 151333- (2023)
Nuclear Dbf2-related (NDR) kinases are a subgroup of evolutionarily conserved AGC protein kinases that regulate various aspects of cell growth and morphogenesis. There are 4 NDR protein kinases in mammals, LATS1, LATS2 and STTK8/NDR1, STK38L/NDR2 pro
Externí odkaz:
https://doaj.org/article/36fd8a03331e478399c077f03bde73f4
Autor:
Li Ling, Fangfang Li, Pinglan Yang, Robert D Oates, Sherman Silber, Cornelia Kurischko, Francis C Luca, N Adrian Leu, Jinwen Zhang, Qiuling Yue, Helen Skaletsky, Laura G Brown, Steve G Rozen, David C Page, P Jeremy Wang, Ke Zheng
Publikováno v:
Biol Reprod
Although hundreds of knockout mice show infertility as a major phenotype, the causative genic mutations of male infertility in humans remain rather limited. Here, we report the identification of a missense mutation (D136G) in the X-linked TAF7L gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d04a0f0fbcbcc9d237e3ee33661a7f79
https://doi.org/10.1093/biolre/ioac093
https://doi.org/10.1093/biolre/ioac093
Publikováno v:
Journal of Visualized Experiments.
Preparation of high-quality mouse eye sections for immunohistochemistry (IHC) is critical for assessing the retinal structure and function and for determining the mechanisms underlying retinal diseases. Maintaining structural integrity throughout the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fb7216f150798b6f9b3909ff3e0968e
https://doi.org/10.3791/59683
https://doi.org/10.3791/59683
Autor:
Gustavo D. Aguirre, Hélène Léger, Eliot T Smith, N. Adrian Leu, William A. Beltran, Francis C. Luca, Evelyn Santana
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-21 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-21 (2018)
Ndr2/Stk38l encodes a protein kinase associated with the Hippo tumor suppressor pathway and is mutated in a naturally-occurring canine early retinal degeneration (erd). To elucidate the retinal functions of Ndr2 and its paralog Ndr1/Stk38, we generat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f41e013a71c30e223be514d1f306036b
https://pubmed.ncbi.nlm.nih.gov/30135513
https://pubmed.ncbi.nlm.nih.gov/30135513
Publikováno v:
Journal of Cell Biology. 202:97-111
The rate of eukaryotic cell growth is tightly controlled for proper progression through each cell cycle stage and is important for cell size homeostasis. It was previously shown that cell growth is inhibited during mitosis when cells are preparing fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d999624fd227fc83c73543321e160452
https://doi.org/10.1083/jcb.201211093
https://doi.org/10.1083/jcb.201211093
Publikováno v:
Eukaryotic Cell. 11:708-717
The r egulation of A ce2 and m orphogenesis (RAM) network is a protein kinase signaling pathway conserved among eukaryotes from yeasts to humans. Among fungi, the RAM network has been most extensively studied in the model yeast Saccharomyces cerevisi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aa272273129e883646763c96b499199
https://doi.org/10.1128/ec.00044-12
https://doi.org/10.1128/ec.00044-12
Publikováno v:
Molecular Biology of the Cell
Cbk1 kinase was previously implicated in regulating polarized morphogenesis, gene expression, and cell integrity. This study reveals that Cbk1 regulates heat shock signaling and stress adaptation by modulating Mpk1 activity and MAPK phosphatase local
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66c3ce80ce6bd2529e6a609ed376f042
https://doi.org/10.1091/mbc.e11-04-0371
https://doi.org/10.1091/mbc.e11-04-0371
Publikováno v:
Molecular Microbiology. 81:831-849
Mechanisms that control mRNA metabolism are critical for cell function, development and stress response. The Saccharomyces cerevisiae mRNA-binding protein Ssd1 has been implicated in mRNA processing, ageing, stress response and maintenance of cell in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8164e8cb67401f645fb5a11a67c7be5
https://doi.org/10.1111/j.1365-2958.2011.07731.x
https://doi.org/10.1111/j.1365-2958.2011.07731.x
Publikováno v:
The Journal of Cell Biology
In the absence of Cbk1 phosphorylation Ssd1-associated mRNAs are redirected from sites of polarized cell growth to stress granules and P-bodies.
The mRNA-binding protein Ssd1 is a substrate for the Saccharomyces cerevisiae LATS/NDR orthologue Cb
The mRNA-binding protein Ssd1 is a substrate for the Saccharomyces cerevisiae LATS/NDR orthologue Cb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::885e5b06c27210a114773287237d6d9a
http://europepmc.org/articles/PMC3044126
http://europepmc.org/articles/PMC3044126
Publikováno v:
Molecular Biology of the Cell. 16:5465-5479
The Saccharomyces cerevisiae mitotic exit network (MEN) is a conserved signaling network that coordinates CDK inactivation, cytokinesis and G1 gene transcription. The MEN Cdc14p phosphatase is sequestered in the nucleolus and transiently released in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::164b18d61049f1bbbda1e082f25a7194
https://doi.org/10.1091/mbc.e05-04-0337
https://doi.org/10.1091/mbc.e05-04-0337