Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Francis Bitsch"'
Autor:
Lukas-Adrian Gurzeler, Marion Link, Yvonne Ibig, Isabel Schmidt, Olaf Galuba, Julian Schoenbett, Christelle Gasser-Didierlaurant, Christian N. Parker, Xiaohong Mao, Francis Bitsch, Markus Schirle, Philipp Couttet, Frederic Sigoillot, Jana Ziegelmüller, Anne-Christine Uldry, Wojciech Teodorowicz, Niko Schmiedeberg, Oliver Mühlemann, Jürgen Reinhardt
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113159- (2023)
Externí odkaz:
https://doaj.org/article/a17f69f34eb64c599e2fdcd86f226d38
Publikováno v:
Journal of the American Society for Mass Spectrometry. 32(8)
With increasing protein therapeutics being designed as non-mAb (non-monoclonal antibody) modalities, additional efforts and resources are required to develop and characterize such therapeutic proteins. Truncation is an emerging issue for manufacturin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6dad62bb30660fc8d06ee30dd5aaf2a
https://pubmed.ncbi.nlm.nih.gov/33395284
https://pubmed.ncbi.nlm.nih.gov/33395284
Autor:
Dieter Seebach, Ralph Woessner, Hauke Hennecke, Henk Schulz, Hansjörg Schild, Alexander K. Nussbaum, Bruno Martinoni, Jürg V. Schreiber, Stefan Abele, Francis Bitsch
Publikováno v:
CHIMIA, Vol 52, Iss 12 (1998)
Interactions and cleavage reactions of ?-amino acids and ?-oligopeptides (up to nine residues, carrying the side chains of Ala, Val, Leu, Ile, Phe, Ser, Lys, and Hop) with biological systems, such as the most potent peptidases (pronase, proteinase K,
Externí odkaz:
https://doaj.org/article/5d36bb67889f4e9fa30370bea6c5fcc6
Autor:
Sébastien Hannedouche, Tewis Bouwmeester, Frederic Bassilana, Noemie Beluch, Jianping Li, Layla Raad, Agnès Hiou-Feige, Corinne Debon, Michel Detheux, José M. Carballido, Keith Mansfield, Nadine Lageyre, Bianka L. Grosshans, Johann Wirsching, Klaus Seuwen, Vincent Lannoy, Nathalie Carte, Philip Smith, Janet Dawson, Thomas Suply, Jeffrey A. Porter, Francis Bitsch, Birgit Baumgarten, Solange Vidal, Rocco Falchetto, Samuel Barbieri, Michael Schaefer, Frank Hillger, Valerie Beck
Publikováno v:
Science signaling. 10(496)
GPR15 is an orphan G protein–coupled receptor (GPCR) that is found in lymphocytes. It functions as a co-receptor of simian immunodeficiency virus and HIV-2 and plays a role in the trafficking of T cells to the lamina propria in the colon and to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5624169695ba9d34ddfedd3b9d4e931
https://pubmed.ncbi.nlm.nih.gov/28900043
https://pubmed.ncbi.nlm.nih.gov/28900043
Autor:
Joerg Kallen, André Strauss, Alain Schilb, Francis Bitsch, Martin Geiser, Virginie Riou, Brigitte Fournier, Ireos Filipuzzi, Jean-Marc Schlaeppi, Alexander Graham
Publikováno v:
Journal of Biological Chemistry. 279:49330-49337
The crystal structure of the ligand binding domain (LBD) of the estrogen-related receptor α (ERRα, NR3B1) complexed with a coactivator peptide from peroxisome proliferator-activated receptor coactivator-1α (PGC-1α) reveals a transcriptionally act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5861c6663b849ca65fdcd63e98e23d6e
https://doi.org/10.1074/jbc.m407999200
https://doi.org/10.1074/jbc.m407999200
Autor:
Brian Cutting, Mauro Zurini, Francis Bitsch, Gabriele Fendrich, André Strauss, Patrick Graff, Janis Liebetanz, Wolfgang Jahnke
Publikováno v:
Journal of Biomolecular NMR. 26:367-372
Culture conditions for successful amino–acid-type selective isotope labeling of proteins expressed in Baculovirus-infected insect cells are described. The method was applied to the selective labeling of the catalytic domain of c-Abl kinase with 15N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dabf2686370cb9a54e864b5a4a6c755d
https://doi.org/10.1023/a:1024013111478
https://doi.org/10.1023/a:1024013111478
Autor:
Brigitte Fournier, Sabine Geisse, Martin Geiser, Isabelle Delhon, Jean-Marc Schlaeppi, Francis Bitsch, Joerg Kallen
Publikováno v:
Structure. 10(12):1697-1707
The retinoic acid-related orphan receptor alpha (RORalpha) is an orphan member of the subfamily 1 of nuclear hormone receptors. No X-ray structure of RORalpha has been described so far, and no ligand has been identified. We describe the first crystal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2557cb6ba3c876e3882860f13ce9975d
Autor:
Isabelle Vachier, Reto Naef, Pascal Channez, Brigitte Charpiot, Lazzaro Mazzoni, Thomas Mueller, Karl-Heinz Buchheit, Francis Bitsch
Publikováno v:
Bioorganic & Medicinal Chemistry. 9:1793-1805
Disease activated drugs (DAD) are pro-drugs of one active principle or combinations of two drugs, which have a proven efficacy for the treatment of the target disease. In opposition to pro-drugs, DAD are activated in inflamed but not normal tissues.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b07a9f811ed10cf33780aa9bdb8f4d2
https://doi.org/10.1016/s0968-0896(01)00077-3
https://doi.org/10.1016/s0968-0896(01)00077-3
Publikováno v:
Enzyme and Microbial Technology. 21:405-412
In order to obtain derivatives of rapamycin, a total of 28 bacterial and 72 fungal strains were screened for their ability to transform rapamycin. In the course of this screening, the already known derivatives 39-o-demethylrapamycin, 27-o-demethylrap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3eb429e54f9e9e395eec77673ddb545e
https://doi.org/10.1016/s0141-0229(97)00013-6
https://doi.org/10.1016/s0141-0229(97)00013-6
Autor:
MICHAELA KUHNT, FRANCIS BITSCH, JULIEN FRANCE, HANS HOFMANN, JEAN-JACQUES SANGLIER, RENE TRABÉR
Publikováno v:
The Journal of Antibiotics. 49:781-787
In order to mimic the human metabolic pathway of cyclosporin A (CyA) a total of 28 bacterial and 72 fungal strains was screened for their ability to transform CyA. Among 3 bacteria and 11 fungi, which produced the main human metabolite OL-17 [eta HyM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74900e3506a2134f694ca41507aeb87e
https://doi.org/10.7164/antibiotics.49.781
https://doi.org/10.7164/antibiotics.49.781