Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Francis A. J. Kerdesky"'
Autor:
Bhadra H. Shelat, Eric A. Voight, Steven M. Hannick, Jerome F. Daanen, Kort Michael E, Francis A. J. Kerdesky, Daniel J. Plata
Publikováno v:
Tetrahedron Letters. 51:5904-5907
Starting from a variety of substituted chroman-4-ones, a highly enantioselective CBS reduction using in situ-generated B–H catalyst gave ( S )-chroman-4-ols. Azide inversion and reduction gave crude ( R )-chroman-4-amines, which could be purified w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47cca33c4f082453d7aa503a50967ce7
https://doi.org/10.1016/j.tetlet.2010.09.006
https://doi.org/10.1016/j.tetlet.2010.09.006
Autor:
David M. Barnes, Jufang Barkalow, Yong Chen, Francis A. J. Kerdesky, John E. Hengeveld, Anthony R. Haight, Bryan Macri, Ashok K. Gupta, Agnes Pal, Brian J. Kotecki
Publikováno v:
Organic Process Research & Development. 13:225-229
The impact of entropic effects on the classical salt resolution of a 2-arylpyrrolidine is described. We have found that the crystallization of a racemic mixture of the base with tartaric acid led to a salt in which the undesired enantiomer is incorpo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cb0d59362c48dc4c483d2151dc2b518
https://doi.org/10.1021/op800242y
https://doi.org/10.1021/op800242y
Autor:
John C. Tolle, Francis A. J. Kerdesky, Seble Wagaw, Calvin L. Becker, Weifeng Wang, Kenneth M. Engstrom
Publikováno v:
Organic Process Research & Development. 12:1114-1118
A convergent, scalable process was developed for the synthesis of adamantane 11-β-hydroxysteroid dehydrogenase-1 inhibitors E-4-(2-methyl-2-(4-(5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)propionylamino)adamantane-1-carboxylic acid (1) and E-4-(2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df6ec9b256cacaf931d62b26c5260219
https://doi.org/10.1021/op800065q
https://doi.org/10.1021/op800065q
Autor:
John E. Lallaman, Jianguo Ji, Wenke Li, Howard E. Morton, Ji Zhang, Francis A. J. Kerdesky, M. Robert Leanna
Publikováno v:
Organic Process Research & Development. 10:512-517
An efficient chemical process for the multikilogram synthesis of ABT-963 (3) is described. The potent and selective COX-2 inhibitor was prepared in four steps in 36% overall isolated yield from commercially available 3,4-difluoroaniline (4). The chem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::337a8c24dfdafd064fcba98fe007c78e
https://doi.org/10.1021/op060016v
https://doi.org/10.1021/op060016v
Autor:
M. Robert Leanna, Eric J. Stoner, Maureen A. McLaughlin, Steven L. Condon, Steven A. King, Francis A. J. Kerdesky, Steven J. Wittenberger, Matthew J. Peterson, Michael Rasmussen, Daniel J. Plata
Publikováno v:
Tetrahedron. 60:10171-10180
A practical and efficient synthesis of ketolide antibiotic cethromycin (ABT-773) (1) is described. An effective protection strategy allows high yielding, regioselective C6-O-alkylation and subsequent stereoselective modification of the erythromycin n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::990cac469b4f323dc77b688cee009d73
https://doi.org/10.1016/j.tet.2004.09.027
https://doi.org/10.1016/j.tet.2004.09.027
Autor:
Gregory S. Wayne, John E. Lallaman, Lakshmi Bhagavatula, Jonathan P. Pease, Ramiya H. Premchandran, Steven A. King, William H. Arnold, Francis A. J. Kerdesky, Howard E. Morton, Sou-Jen Chang
Publikováno v:
Organic Process Research & Development. 6:869-875
An efficient and practical synthesis of 2‘-O-benzoyl-3-keto-6-O-propargyl-11,12-carbamoyl erythromycin A (4) is described. The semisynthetic macrolide was prepared on large scale in seven steps in 38% overall isolated yield from the readily availab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b69503992080c905ff0b708a26f8db0a
https://doi.org/10.1021/op025535m
https://doi.org/10.1021/op025535m
Autor:
Michael Fitzgerald, Michael S. Allen, Francis A. J. Kerdesky, Lakshmi Bhagavatula, J. A. Menzia, Timothy L. Stuk, Anthony R. Haight, Timothy A. Robbins, Shyamal I. Parekh, Steven M. Hannick, and David Scarpetti, Jien-Heh J. Tien
Publikováno v:
Organic Process Research & Development. 3:94-100
The reduction of (5S)-2-amino-5-dibenzylamino-4-oxo-1,6-diphenylhex-2-ene was optimized for diastereoselectivity and overall conversion to (2S,3S,5S)-5-amino-2-dibenzylamino-3-hydroxy-1,6-diphenylhexane (2a). A two-step reduction sequence is describe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1768dca23e201241c30ff2bf6e79e668
https://doi.org/10.1021/op9802071
https://doi.org/10.1021/op9802071
Publikováno v:
Synthetic Communications. 26:1007-1013
A novel and efficient synthesis of A-81988, an angiotensin II receptor antagonist, is described. The key step utilizes a palladium-catalyzed biaryl coupling between a phenylboronic acid derivative and N-trityl-5-(2-bromophenyl)tetrazole.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c4b86e14121a5407e74ae9e54fd23ed
https://doi.org/10.1080/00397919608003705
https://doi.org/10.1080/00397919608003705
Autor:
Francis A. J. Kerdesky, Louis S. Seif
Publikováno v:
Synthetic Communications. 25:4081-4086
The hydrogenation of halothiazoles is described. The best results were obtained utilizing 10% palladium on carbon as catalyst at four atmospheres of pressure with the bromide derivatives.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8910a97e7671bcc6c96c9cb8f0b8a93f
https://doi.org/10.1080/00397919508011485
https://doi.org/10.1080/00397919508011485
Autor:
Francis A. J. Kerdesky, Louis S. Seif
Publikováno v:
Synthetic Communications. 25:2639-2645
A novel and efficient synthesis of 5-(hydroxymethyl) thiazole, an important synthon for the preparation of biologically active compounds, is described. The research also provides additional insight into the properties of halothiazoles.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d7acd72da6e2888975430a1da1a1eb9
https://doi.org/10.1080/00397919508011810
https://doi.org/10.1080/00397919508011810