Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Francis A. Ayuk"'
Autor:
Inga Hansen, Julian Kött, Silke Heidenreich, Francis A. Ayuk, Patricia Doll, Finn Abeck, Nina Booken, Christoffer Gebhardt, Stefan W. Schneider
Publikováno v:
JEADV Clinical Practice, Vol 3, Iss 1, Pp 317-320 (2024)
Abstract Immune checkpoint inhibitors have established in the treatment of malignant melanoma and have significantly improved prognosis in advanced tumour stages. As they interfere with immunoregulatory pathways by blocking checkpoints, nonspecific a
Externí odkaz:
https://doaj.org/article/ea3af48b841d4a40abaacdc47bb1db9f
Autor:
Evren Bayraktar, Theresa Graf, Francis A. Ayuk, Gernot Beutel, Olaf Penack, Thomas Luft, Nicole Brueder, Gastone Castellani, H. Christian Reinhardt, Nicolaus Kröger, Dietrich W. Beelen, Amin T. Turki
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Despite advances in allogeneic hematopoietic cell transplantation, acute graft-versus-host disease (aGVHD) remains its leading complication, yet with heterogeneous outcomes. Here, we analyzed aGVHD phenotypes and clinical classifications in
Externí odkaz:
https://doaj.org/article/bb726bc78632416a8d9d063e67a7b93f
Autor:
Maraike Harfmann, Tanja Schröder, Dawid Głów, Maximilian Jung, Almut Uhde, Nicolaus Kröger, Stefan Horn, Kristoffer Riecken, Boris Fehse, Francis A. Ayuk
Publikováno v:
Cancers, Vol 16, Iss 2, p 334 (2024)
Background: CAR-T cell therapy has shown impressive results and is now part of standard-of-care treatment of B-lineage malignancies, whereas the treatment of myeloid diseases has been limited by the lack of suitable targets. CD45 is expressed on almo
Externí odkaz:
https://doaj.org/article/07fe5cf1325b4994ab5d50273a349540
Autor:
Nico Gagelmann, Francis A. Ayuk, Evgeny Klyuchnikov, Christine Wolschke, Susanna Carolina Berger, Nicolaus Kröger
Publikováno v:
Haematologica, Vol 108, Iss 10 (2023)
Externí odkaz:
https://doaj.org/article/6500714330dc4e408008243ae395b75c
Autor:
Susanna Carolina Berger, Boris Fehse, Nuray Akyüz, Maria Geffken, Christine Wolschke, Dietlinde Janson, Nico Gagelmann, Marlene Luther, Dominic Wichmann, Christian Frenzel, Guenther Thayssen, Anna Alegiani, Anita Badbaran, Silke Zeschke, Judith Dierlamm, Nicolaus Kröger, Francis A. Ayuk
Publikováno v:
Haematologica, Vol 108, Iss 2 (2022)
CD19-specific chimeric antigen receptor (CD19-CAR) T-cell therapies mediate durable responses in late-stage B-cell malignancies, but can be complicated by a potentially severe immune effector cell-associated neurotoxicity syndrome (ICANS). Despite br
Externí odkaz:
https://doaj.org/article/6a291010901a42279b07877a1f0e54c0
Autor:
Boris Fehse, Anita Badbaran, Carolina Berger, Tanja Sonntag, Kristoffer Riecken, Maria Geffken, Nicolaus Kröger, Francis A. Ayuk
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 16, Iss , Pp 172-178 (2020)
Treatment with axicabtagene ciloleucel (Axi-cel) CD19-CAR-T (chimeric antigen receptor T) cells has been approved for refractory/relapsed diffuse large B cell lymphoma (DLBCL) and primary mediastinal large B cell lymphoma (PMBCL). Because treatment s
Externí odkaz:
https://doaj.org/article/0ef2052a84b24f2fbe81c5a1227bd768
Autor:
Anita Badbaran, Carolina Berger, Kristoffer Riecken, Anne Kruchen, Maria Geffken, Ingo Müller, Nicolaus Kröger, Francis A. Ayuk, Boris Fehse
Publikováno v:
Cancers, Vol 12, Iss 7, p 1970 (2020)
Immunotherapy with CD19-specific chimeric antigen receptor (CAR-) T cells has shown excellent efficacy in relapsed/refractory B-cell cancers. The in vivo expansion and persistence of CAR-T cells after infusion are important response- and toxicity-det
Externí odkaz:
https://doaj.org/article/f7811c63712c4b3cae1a7b3627074d21
Autor:
Peter Bader, Claudia Rossig, Martin Hutter, Francis Ayuketang Ayuk, Claudia D. Baldus, Veit L. Bücklein, Halvard Bonig, Gunnar Cario, Hermann Einsele, Udo Holtick, Christian Koenecke, Shahrzad Bakhtiar, Annette Künkele, Roland Meisel, Fabian Müller, Ingo Müller, Olaf Penack, Eva Rettinger, Martin G. Sauer, Paul-Gerhardt Schlegel, Jan Soerensen, Arend von Stackelberg, Brigitte Strahm, Julia Hauer, Tobias Feuchtinger, Andrea Jarisch
Publikováno v:
Blood Advances. 7:2436-2448
Patients with precursor B-cell acute lymphoblastic leukemia (pB-ALL) who have relapsed after allogeneic hematopoietic stem cell transplantation (allo-HSCT), have relapsed more than once, or are resistant upfront have a dismal prognosis. CD19-targeted
Autor:
Maja-Theresa Dieterlen, Kristin Klaeske, Alexander A. Bernhardt, Michael A. Borger, Sara Klein, Jens Garbade, Sven Lehmann, Francis Ayuketang Ayuk, Herrmann Reichenspurner, Markus J. Barten
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
BackgroundExtracorporeal photopheresis (ECP) induces immunological changes that lead to a reduced risk of transplant rejection. The aim of the present study was to determine optimum conditions for ECP treatment by analyzing a variety of tolerance-ind
Externí odkaz:
https://doaj.org/article/9e20f57845e04d4e8d621edbd68297a3
Autor:
Tatjana Holzer, Stefanie Biedermann, Inga Herfort, Birte Friedrichs, Silke Holtkamp, Linda Hanssens, Mario Assenmacher, Ulf Bethke, Dina Schneider, Stefan Miltenyi, Toon Overstijns, Christoph Schmid, Francis A. Ayuk, Christoph Scheid, Anja Jühling, Udo Holtick, Philipp Gödel, Peter Borchmann, Iris Bürger
Publikováno v:
Blood. 140:4581-4583