Zobrazeno 1 - 10
of 361
pro vyhledávání: '"Francis A Ortega"'
Autor:
Zaniar Ghazizadeh, Jiajun Zhu, Faranak Fattahi, Alice Tang, Xiaolu Sun, Sadaf Amin, Su-Yi Tsai, Mona Khalaj, Ting Zhou, Ryan M. Samuel, Tuo Zhang, Francis A. Ortega, Miriam Gordillo, Dorota Moroziewicz, Daniel Paull, Scott A. Noggle, Jenny Zhaoying Xiang, Lorenz Studer, David J. Christini, Geoffrey S. Pitt, Todd Evans, Shuibing Chen
Publikováno v:
iScience, Vol 25, Iss 4, Pp 104153- (2022)
Summary: The sinoatrial node (SAN) is the primary pacemaker of the heart. The human SAN is poorly understood due to limited primary tissue access and limitations in robust in vitro derivation methods. We developed a dual SHOX2:GFP; MYH6:mCherry knock
Externí odkaz:
https://doaj.org/article/fef061437c7f48f58546ebc077cf20d3
Autor:
Serge Sicular, Mehmet Alpaslan, Francis A. Ortega, Nora Keathley, Srivas Venkatesh, Rebecca M. Jones, Robert V. Lindsey
Publikováno v:
Respiratory Medicine Case Reports, Vol 39, Iss , Pp 101733- (2022)
Lung cancer is often missed on chest radiographs, despite chest radiography typically being the first imaging modality in the diagnosis pathway. We present a 46 year-old male with chest pain referred for chest X-ray, and initial interpretation report
Externí odkaz:
https://doaj.org/article/4a5e72b4f56c4c9ba5b5fe1df69fa674
Publikováno v:
Frontiers in Physiology, Vol 8 (2018)
Dynamic clamp, a hybrid-computational-experimental technique that has been used to elucidate ionic mechanisms underlying cardiac electrophysiology, is emerging as a promising tool in the discovery of potential anti-arrhythmic targets and in pharmacol
Externí odkaz:
https://doaj.org/article/0ea4d51a30f84a319f332ff8fd449ee4
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
In silico cardiac myocyte models present powerful tools for drug safety testing and for predicting phenotypical consequences of ion channel mutations, but their accuracy is sometimes limited. For example, several models describing human ventricular e
Externí odkaz:
https://doaj.org/article/582cb2052ed644cda88a02e6e89bf906
Autor:
Kemar Brown, Stephanie Legros, Francis A Ortega, Yunkai Dai, Michael Xavier Doss, David J Christini, Richard B Robinson, Ann C Foley
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189818 (2017)
In vivo, cardiomyocytes comprise a heterogeneous population of contractile cells defined by unique electrophysiologies, molecular markers and morphologies. The mechanisms directing myocardial cells to specific sub-lineages remain poorly understood. H
Externí odkaz:
https://doaj.org/article/b5f7aed9224a42478ecb7be635eb5f22
Autor:
Zaniar, Ghazizadeh, Jiajun, Zhu, Faranak, Fattahi, Alice, Tang, Xiaolu, Sun, Sadaf, Amin, Su-Yi, Tsai, Mona, Khalaj, Ting, Zhou, Ryan M, Samuel, Tuo, Zhang, Francis A, Ortega, Miriam, Gordillo, Dorota, Moroziewicz, Daniel, Paull, Scott A, Noggle, Jenny Zhaoying, Xiang, Lorenz, Studer, David J, Christini, Geoffrey S, Pitt, Todd, Evans, Shuibing, Chen
Publikováno v:
iScience. 25(4)
The sinoatrial node (SAN) is the primary pacemaker of the heart. The human SAN is poorly understood due to limited primary tissue access and limitations in robust
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d519a640ec8271ca23bd68d2f96d3e1b
https://pubmed.ncbi.nlm.nih.gov/35434558
https://pubmed.ncbi.nlm.nih.gov/35434558
Autor:
Willemijn Groenendaal, Francis A Ortega, Armen R Kherlopian, Andrew C Zygmunt, Trine Krogh-Madsen, David J Christini
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 4, p e1004242 (2015)
The traditional cardiac model-building paradigm involves constructing a composite model using data collected from many cells. Equations are derived for each relevant cellular component (e.g., ion channel, exchanger) independently. After the equations
Externí odkaz:
https://doaj.org/article/955d66251d1f439a96259fddd41f95af
Autor:
Isabella Mengarelli, Arie O. Verkerk, Francis A. Ortega, Ruben Coronel, David J. Christini, Trine Krogh-Madsen, Edward J. Vigmond, Namit Gaur
Publikováno v:
Journal of Molecular and Cellular Cardiology
Journal of Molecular and Cellular Cardiology, Elsevier, 2020, 145, pp.122-132. ⟨10.1016/j.yjmcc.2020.04.019⟩
Journal of molecular and cellular cardiology, 145, 122-132. Academic Press Inc.
Journal of Molecular and Cellular Cardiology, Elsevier, 2020, 145, pp.122-132. ⟨10.1016/j.yjmcc.2020.04.019⟩
Journal of molecular and cellular cardiology, 145, 122-132. Academic Press Inc.
Repolarization reserve, the robustness of a cell to repolarize even when one of the repolarization mechanisms is failing, has been described qualitatively in terms of ionic currents, but has not been quantified by a generic metric that is applicable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95c82429aefd2325f3b6c2439d8bee68
https://hal.archives-ouvertes.fr/hal-03492208
https://hal.archives-ouvertes.fr/hal-03492208
Publikováno v:
Applications of Machine Learning 2020.
Conventional microscopy focusing methods perform a time consuming sweep through the Z-axis in order to estimate the focal plane. As an alternative, we developed a deep learning model that predicts in one shot the distance offset to the focal plane fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0a50f356f558eda89e50f26e7973478
https://doi.org/10.1117/12.2568990
https://doi.org/10.1117/12.2568990
Publikováno v:
Applications of Machine Learning 2020.
Low signal to noise ratio (SNR) conditions degrade microscopy imaging quality, which complicates downstream post-processing and analysis. One conventional method to improve SNR by reducing noise is to average a large number of sequentially acquired i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42dfa91d8f7fe0f9dd9c6d89531c302e
https://doi.org/10.1117/12.2568986
https://doi.org/10.1117/12.2568986