SJL mice infected with Acanthamoeba castellanii develop central nervous system autoimmunity through the generation of cross-reactive T cells for myelin antigens.

Autor: Chandirasegaran Massilamany, Francine Marciano-Cabral, Bruno da Rocha-Azevedo, Melissa Jamerson, Arunakumar Gangaplara, David Steffen, Rana Zabad, Zsolt Illes, Raymond A Sobel, Jay Reddy

Publikováno v: PLoS ONE, Vol 9, Iss 5, p e98506 (2014)

We recently reported that Acanthamoeba castellanii (ACA), an opportunistic pathogen of the central nervous system (CNS) possesses mimicry epitopes for proteolipid protein (PLP) 139-151 and myelin basic protein 89-101, and that the epitopes induce exp

Externí odkaz: https://doaj.org/article/a2d2e596145c4eb9808305e9df4324ee

Diagnosis of Infections Caused by Pathogenic Free-Living Amoebae

Autor: Bruno da Rocha-Azevedo, Herbert B. Tanowitz, Francine Marciano-Cabral

Publikováno v: Interdisciplinary Perspectives on Infectious Diseases, Vol 2009 (2009)

Naegleria fowleri, Acanthamoeba spp., Balamuthia mandrillaris, and Sappinia sp. are pathogenic free-living amoebae. N. fowleri causes Primary Amoebic Meningoencephalitis, a rapidly fatal disease of the central nervous system, while Acanthamoeba spp.

Externí odkaz: https://doaj.org/article/2209aa67c7d345c48bd0ea48ebf85abb

Genomics and transcriptomics yields a system-level view of the biology of the pathogen Naegleria fowleri

Autor: Kristína Záhonová, Lillian K. Fritz-Laylin, Georgina Macintyre, Denise C. Zysset-Burri, Michael L. Ginger, Marek Eliáš, Matthew T. Weirauch, Joel B. Dacks, Geoffrey J. Puzon, Inmaculada Ramírez-Macías, Tom Walsh, Emily K. Herman, Anastasios D. Tsaousis, Katrina B. Velle, Alexander L. Greninger, Francine Marciano-Cabral, Romana Vargová, Norbert Müller, Charles Y. Chiu, Sebastian Rodrigo Najle, Mark van der Giezen, Haylea C. Miller, Claudio H. Slamovits, Matthew J. Morgan, Mattias Wittwer

Publikováno v: BMC Biology
Herman, Emily K; Greninger, Alex; van der Giezen, Mark; Ginger, Michael L; Ramirez-Macias, Inmaculada; Miller, Haylea C; Morgan, Matthew J; Tsaousis, Anastasios D; Velle, Katrina; Vargová, Romana; Záhonová, Kristína; Najle, Sebastian Rodrigo; MacIntyre, Georgina; Muller, Norbert; Wittwer, Mattias; Zysset-Burri, Denise Corinne; Eliáš, Marek; Slamovits, Claudio H; Weirauch, Matthew T; Fritz-Laylin, Lillian; ... (2021). Genomics and transcriptomics yields a system-level view of the biology of the pathogen Naegleria fowleri. BMC biology, 19(1), p. 142. BioMed Central 10.1186/s12915-021-01078-1
BMC Biology, Vol 19, Iss 1, Pp 1-18 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
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[Background] The opportunistic pathogen Naegleria fowleri establishes infection in the human brain, killing almost invariably within 2 weeks. The amoeba performs piece-meal ingestion, or trogocytosis, of brain material causing direct tissue damage an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f65e98aaa4032faf2ad946d969104d0b
https://doi.org/10.1186/s12915-021-01078-1

A comparative ‘omics approach to candidate pathogenicity factor discovery in the brain-eating amoebaNaegleria fowleri

Autor: Norbert Müller, Mark van der Giezen, Claudio H. Slamovits, Kristína Záhonová, Denise C. Zysset-Burri, Matthew T. Weirauch, Anastasios D. Tsaousis, Sebastian Rodrigo Najle, Haylea C. Miller, Katrina B. Velle, Matthias Wittwer, Marek Eliáš, Tom Walsh, Romana Vargová, Joel B. Dacks, Geoffrey J. Puzon, Francine Marciano-Cabral, Charles Y. Chiu, Michael L. Ginger, Alex Greninger, Lillian K. Fritz-Laylin, Georgina Macintyre, Inmaculada Ramírez-Macías, Emily K. Herman, Matthew J. Morgan

Of the 40 describedNaegleriaspecies, onlyN. fowlerican establish infection in humans, killing almost invariably within two weeks. In the brain, the amoeba performs piece-meal ingestion, or trogocytosis, of brain material causing massive inflammation.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f70e65bd960ae9dfa831ed97b6ac54d1
https://doi.org/10.1101/2020.01.16.908186

Identification of Naegleria fowleri proteins linked to primary amoebic meningoencephalitis

Autor: Francine Marciano-Cabral, Jay Park, Melissa Jamerson, Guy A. Cabral, Jacqueline A Schmoyer

Publikováno v: Microbiology. 163:322-332

Naegleria fowleri (N. fowleri) causes primary amoebic meningoencephalitis, a rapidly fatal disease of the central nervous system. N. fowleri can exist in cyst, flagellate or amoebic forms, depending on environmental conditions. The amoebic form can i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c481d89de6f6d7f73c885a668b39db4
https://doi.org/10.1099/mic.0.000428