Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Francine Liard"'
Publikováno v:
Pharmaceutical Research. 21:2079-2084
The current study describes the design and validation of a novel oral vehicle for delivering poorly water-soluble herpes simplex virus (HSV)-helicase inhibitors in preclinical pharmacokinetic (PK) and pharmacodynamic (PD) evaluations.Poorly water-sol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41bca4574113d7bdb5cfaf28487ccd53
https://doi.org/10.1023/b:pham.0000048200.98837.6f
https://doi.org/10.1023/b:pham.0000048200.98837.6f
Autor:
Francine Liard, Nicole Lapeyre, Michel Garneau, Gordon Bolger, Jorge Jaramillo, Thaddeus D. Allen
Publikováno v:
Antiviral Research. 35:157-165
Using the SKH-1 hairless mouse (HM) we have addressed the issue as to whether topically applied acyclovir (ACV) may mediate some of its antiviral actions by a systemic effect. When topically applied in a formulation consisting of polyvinyl alcohol (2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e94ac486021ead0244c572150347e7c2
https://doi.org/10.1016/s0166-3542(97)00024-7
https://doi.org/10.1016/s0166-3542(97)00024-7
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 14:151-154
A novel series of hydroxyethylamine-based inhibitors of HIV protease which contain a substituted pipecolinic amide were developed. After preliminary screening, a representative of this series, compound BILA 2185 BS, demonstrated an IC 50 value of 3.3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a490baa89451aaf21696ad50fdb56574
https://doi.org/10.1016/0731-7085(95)01625-2
https://doi.org/10.1016/0731-7085(95)01625-2
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 70:377-384
The contractile activity of and binding sites for endothelin-1 (ET-1) were investigated in isolated guinea-pig ileal longitudinal smooth muscle (GPILM). ET-1 produced concentration-dependent contractions of GPILM that either slowly subsided in the co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32cfb70342ed1d924b7299d2fbe17abf
https://doi.org/10.1139/y92-047
https://doi.org/10.1139/y92-047
Autor:
Michel Garneau, Nicole Lapeyre-Paquette, Montse Llinas-Brunet, Youla S. Tsantrizos, Anne-Marie Faucher, Christian Brochu, Ghiro Elise, Vida Gorys, Francine Liard, Murray D. Bailey, Ted Halmos, Martin Poirier, Daniel Lamarre, Gordon Bolger, Manon Rhéaume, Jean Marie Ferland, Chantal Grand-Maître
Publikováno v:
Journal of medicinal chemistry. 47(7)
From the discovery of competitive hexapeptide inhibitors, potent and selective HCV NS3 protease macrocyclic inhibitors have been identified. Structure-activity relationship studies were performed focusing on optimizing the N-terminal carbamate and th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a01e6eaf4a839ffb890587353b1d286
https://pubmed.ncbi.nlm.nih.gov/15027850
https://pubmed.ncbi.nlm.nih.gov/15027850
Autor:
Jianmin Duan, Michael G. Cordingley, Michel Liuzzi, Bruno Simoneau, Abigail Browne, Anne-Marie Faucher, Francine Liard, Nathalie Dansereau, William Paris
This study investigated the oral bioavailability and efficacy of BILS 45 BS, a selective herpes simplex virus (HSV) helicase-primase inhibitor, against acyclovir (ACV)-resistant (ACV r ) infections mediated by the HSV type 1 (HSV-1) dl sptk and PAA r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71c20f94807585d859b8690825dc4471
https://europepmc.org/articles/PMC155846/
https://europepmc.org/articles/PMC155846/
Autor:
Louis Plamondon, William Paris, Francine Liard, Daniel Lamarre, Paul C. Anderson, Pierre L. Beaulieu, Gilbert Croteau, Dominik Wernic, Francois Soucy, Liang Tong, Vida Gorys, Susan Pav, Diane Thibeault, Dale R. Cameron, Chantal Grand-Maître, Christiane Yoakim
Publikováno v:
Journal of medicinal chemistry. 43(6)
Starting from palinavir (1), our lead HIV protease inhibitor, we have discovered a new series of truncated analogues in which the P(3)-P(2) quinaldic-valine portion of 1 was replaced by 2', 6'-dimethylphenoxyacetyl. With EC(50)'s in the 1-2 nM range,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::468c8b2501190b16291ce68d35e4c559
https://pubmed.ncbi.nlm.nih.gov/10737742
https://pubmed.ncbi.nlm.nih.gov/10737742
Autor:
Daniel Lamarre, Diane Thibeault, Francine Liard, Jorge Jaramillo, Grace Jung, Bruno Simoneau, Gordon Bolger, Jean-Claude Vigeant, Paul C. Anderson, Louise Pilote
Publikováno v:
Canadian journal of physiology and pharmacology. 77(11)
The human renin infused rat model (HRIRM) was used as an in vivo small-animal model for evaluating the efficacy of a collection of inhibitors of human renin. The intravenous infusion of recombinant human renin (2.4 µg·kg-1·min-1) in the ganglion-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e8ab6b04a5b1afb6dabf1b7b036f730
https://pubmed.ncbi.nlm.nih.gov/10593662
https://pubmed.ncbi.nlm.nih.gov/10593662
Publikováno v:
Journal of pharmaceutical sciences. 87(6)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab9128f8c8d46bae83a2d06a47edf5ec
https://pubmed.ncbi.nlm.nih.gov/9607960
https://pubmed.ncbi.nlm.nih.gov/9607960
Publikováno v:
Canadian journal of physiology and pharmacology. 69(8)
The potential interaction (s) between atrial natriuretic factor (ANF) and porcine–human endothelin (ET-1) was investigated in the endothelium-denuded rat aortic ring preparation. ET-1 produced a sustained contraction of aortic rings with an ED50 of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f8e67c79dd021e0a277320f18eecff5
https://pubmed.ncbi.nlm.nih.gov/1838297
https://pubmed.ncbi.nlm.nih.gov/1838297