Výsledky vyhledávání - "Francine E. Garrett-Bakelman"

Akademický článek

Multi-ancestry epigenome-wide analyses identify methylated sites associated with aortic augmentation index in TOPMed MESA

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)

Abstract Despite the prognostic value of arterial stiffness (AS) and pulsatile hemodynamics (PH) for cardiovascular morbidity and mortality, epigenetic modifications that contribute to AS/PH remain unknown. To gain a better understanding of the link

Externí odkaz: https://doaj.org/article/2566eec7931e4736bf4aa961b170b4a1

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Akademický článek

DNA methylation landscapes of 1538 breast cancers reveal a replication-linked clock, epigenomic instability and cis-regulation

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)

Understanding the molecular mechanisms underlying DNA methylation in cancer and its clinical relevance remains crucial. Here, the authors study RRBS-based profiles of 1538 breast tumours and 244 normal breast tissues from the METABRIC cohort and repo

Externí odkaz: https://doaj.org/article/7832b4cd7ff242839e4e5e73265c879e

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Akademický článek

COCOA: coordinate covariation analysis of epigenetic heterogeneity

Autor: John T. Lawson, Jason P. Smith, Stefan Bekiranov, Francine E. Garrett-Bakelman, Nathan C. Sheffield

Publikováno v: Genome Biology, Vol 21, Iss 1, Pp 1-23 (2020)

Abstract A key challenge in epigenetics is to determine the biological significance of epigenetic variation among individuals. We present Coordinate Covariation Analysis (COCOA), a computational framework that uses covariation of epigenetic signals a

Externí odkaz: https://doaj.org/article/bc97834d68b740c984d5e872e29801cd

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Akademický článek

An Esrrb and Nanog Cell Fate Regulatory Module Controlled by Feed Forward Loop Interactions

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Cell fate decisions during development are governed by multi-factorial regulatory mechanisms including chromatin remodeling, DNA methylation, binding of transcription factors to specific loci, RNA transcription and protein synthesis. However, the mec

Externí odkaz: https://doaj.org/article/67b02d769bf444e29916c542735c28dd

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Akademický článek

Cell-free DNA (cfDNA) and Exosome Profiling from a Year-Long Human Spaceflight Reveals Circulating Biomarkers

Publikováno v: iScience, Vol 23, Iss 12, Pp 101844- (2020)

Summary: Liquid biopsies based on cell-free DNA (cfDNA) or exosomes provide a noninvasive approach to monitor human health and disease but have not been utilized for astronauts. Here, we profile cfDNA characteristics, including fragment size, cellula

Externí odkaz: https://doaj.org/article/03949e9af66945e29ccf6aa8c8313a46

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Akademický článek

Validation of CRISPR targeting for proliferation and cytarabine resistance control genes in the acute myeloid leukemia cell line MOLM-13

Autor: Subhash C Prajapati, Nicholas Dunham, Hao Fan, Francine E Garrett-Bakelman

Publikováno v: BioTechniques, Vol 72, Iss 3, Pp 81-84 (2022)

Acute myeloid leukemia patients with FMS-like tyrosine kinase 3–internal tandem duplications and mixed lineage leukemia–protein AF9 fusion proteins suffer from poor clinical outcomes. The MOLM-13 acute myeloid leukemia cell line harbors both of t

Externí odkaz: https://doaj.org/article/eea737c93eee4030afede8a113d58336

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Acute myeloid leukemia stratifies as two clinically relevant sphingolipidomic subtypes

Autor: B. Bishal Paudel, Su-Fern Tan, Todd E. Fox, Johnson Ung, Jeremy Shaw, Wendy Dunton, Irene Lee, Arati Sharma, Aaron D. Viny, Brian M. Barth, Martin S. Tallman, Myles Cabot, Francine E. Garrett-Bakelman, Ross L. Levine, Mark Kester, David Claxton, David J. Feith, Kevin A. Janes, Thomas P. Loughran

Publikováno v: bioRxiv

Acute myeloid leukemia (AML) is an aggressive disease with complex and heterogeneous biology. Although several genomic classifications have been proposed, there is a growing interest in going beyond genomics to stratify AML. In this study, we profile

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d818fb462fe8955009591cb49d720dd6
https://europepmc.org/articles/PMC10153188/

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