Brain cross‐protection against SARS‐CoV‐2 variants by a lentiviral vaccine in new transgenic mice

Autor: Min‐Wen Ku, Pierre Authié, Maryline Bourgine, François Anna, Amandine Noirat, Fanny Moncoq, Benjamin Vesin, Fabien Nevo, Jodie Lopez, Philippe Souque, Catherine Blanc, Ingrid Fert, Sébastien Chardenoux, llta Lafosse, Delphine Cussigh, David Hardy, Kirill Nemirov, Françoise Guinet, Francina Langa Vives, Laleh Majlessi, Pierre Charneau

Publikováno v: EMBO Molecular Medicine, Vol 13, Iss 12, Pp 1-21 (2021)

Abstract COVID‐19 vaccines already in use or in clinical development may have reduced efficacy against emerging SARS‐CoV‐2 variants. In addition, although the neurotropism of SARS‐CoV‐2 is well established, the vaccine strategies currently

Externí odkaz: https://doaj.org/article/e281ac5ccf5c4d798e95aba80cc3ff64

Mitochondrial AIF loss causes metabolic reprogramming, caspase-independent cell death blockade, embryonic lethality, and perinatal hydrocephalus

Autor: Laure Delavallée, Navrita Mathiah, Lauriane Cabon, Aurélien Mazeraud, Marie-Noelle Brunelle-Navas, Leticia K. Lerner, Mariana Tannoury, Alexandre Prola, Raquel Moreno-Loshuertos, Mathieu Baritaud, Laura Vela, Kevin Garbin, Delphine Garnier, Christophe Lemaire, Francina Langa-Vives, Martine Cohen-Salmon, Patricio Fernández-Silva, Fabrice Chrétien, Isabelle Migeotte, Santos A. Susin

Publikováno v: Molecular Metabolism, Vol 40, Iss , Pp 101027- (2020)

Objectives: Apoptosis-Inducing Factor (AIF) is a protein involved in mitochondrial electron transport chain assembly/stability and programmed cell death. The relevant role of this protein is underlined because mutations altering mitochondrial AIF pro

Externí odkaz: https://doaj.org/article/8c134e4208ad45a592079ac9a2feb0b1

Clonal hematopoiesis driven by chromosome 1q/MDM4 trisomy defines a canonical route toward leukemia in Fanconi anemia

Autor: Marie Sebert, Stéphanie Gachet, Thierry Leblanc, Alix Rousseau, Olivier Bluteau, Rathana Kim, Raouf Ben Abdelali, Flore Sicre de Fontbrune, Loïc Maillard, Carèle Fedronie, Valentine Murigneux, Léa Bellenger, Naira Naouar, Samuel Quentin, Lucie Hernandez, Nadia Vasquez, Mélanie Da Costa, Pedro H. Prata, Lise Larcher, Marie de Tersant, Matthieu Duchmann, Anna Raimbault, Franck Trimoreau, Odile Fenneteau, Wendy Cuccuini, Nathalie Gachard, Nathalie Auger, Giulia Tueur, Maud Blanluet, Claude Gazin, Michèle Souyri, Francina Langa Vives, Aaron Mendez-Bermudez, Hélène Lapillonne, Etienne Lengline, Emmanuel Raffoux, Pierre Fenaux, Lionel Adès, Edouard Forcade, Charlotte Jubert, Carine Domenech, Marion Strullu, Bénédicte Bruno, Nimrod Buchbinder, Caroline Thomas, Arnaud Petit, Guy Leverger, Gérard Michel, Marina Cavazzana, Eliane Gluckman, Yves Bertrand, Nicolas Boissel, André Baruchel, Jean-Hugues Dalle, Emmanuelle Clappier, Eric Gilson, Ludovic Deriano, Sylvie Chevret, François Sigaux, Gérard Socié, Dominique Stoppa-Lyonnet, Hugues de Thé, Christophe Antoniewski, Dominique Bluteau, Régis Peffault de Latour, Jean Soulier

Publikováno v: Cell Stem Cell
Cell Stem Cell, 2023, 30 (2), pp.153-170.e9. ⟨10.1016/j.stem.2023.01.006⟩

International audience; Fanconi anemia (FA) patients experience chromosome instability, yielding hematopoietic stem/progenitor cell (HSPC) exhaustion and predisposition to poor-prognosis myeloid leukemia. Based on a longitudinal cohort of 335 patient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c04c73d99e0cccd9d3216befe9e7cea
https://hal.science/hal-04157812

MITF - A controls branching morphogenesis and nephron endowment.

Autor: Aurélie Phelep, Denise Laouari, Kapil Bharti, Martine Burtin, Salvina Tammaccaro, Serge Garbay, Clément Nguyen, Florence Vasseur, Thomas Blanc, Sophie Berissi, Francina Langa-Vives, Evelyne Fischer, Anne Druilhe, Heinz Arnheiter, Gerard Friedlander, Marco Pontoglio, Fabiola Terzi

Publikováno v: PLoS Genetics, Vol 13, Iss 12, p e1007093 (2017)

Congenital nephron number varies widely in the human population and individuals with low nephron number are at risk of developing hypertension and chronic kidney disease. The development of the kidney occurs via an orchestrated morphogenetic process

Externí odkaz: https://doaj.org/article/6752b6f74c8d47d5b382dee7a6c03339

Rab35-regulated lipid turnover by myotubularins represses mTORC1 activity and controls myelin growth

Autor: Kerstin Klinkert, Volker Haucke, Alessandra Bolino, Genaro Patino-Lopez, Linda Sawade, Francina Langa-Vives, Federica Grandi, Marianna Mignanelli, Roberta Di Guardo, Arnaud Echard

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Nature Communications
Nature Communications, 2020, 11 (1), pp.2835. ⟨10.1038/s41467-020-16696-6⟩
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.2835. ⟨10.1038/s41467-020-16696-6⟩

Inherited peripheral neuropathies (IPNs) represent a broad group of disorders including Charcot-Marie-Tooth (CMT) neuropathies characterized by defects primarily arising in myelin, axons, or both. The molecular mechanisms by which mutations in nearly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d272e17089887567cb28e00b272173e6
https://doaj.org/article/d1e62855b2dc4aa889b4c3bfd2e4dbff