Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Francien Talens"'
Autor:
Dario Zimmerli, Chiara S. Brambillasca, Francien Talens, Jinhyuk Bhin, Renske Linstra, Lou Romanens, Arkajyoti Bhattacharya, Stacey E. P. Joosten, Ana Moises Da Silva, Nuno Padrao, Max D. Wellenstein, Kelly Kersten, Mart de Boo, Maurits Roorda, Linda Henneman, Roebi de Bruijn, Stefano Annunziato, Eline van der Burg, Anne Paulien Drenth, Catrin Lutz, Theresa Endres, Marieke van de Ven, Martin Eilers, Lodewyk Wessels, Karin E. de Visser, Wilbert Zwart, Rudolf S. N. Fehrmann, Marcel A. T. M. van Vugt, Jos Jonkers
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Tripe-negative breast cancers poorly respond to immune checkpoint inhibition therapy, due to their immune-hostile tumour microenvironment. Authors here show that the oncogene MYC plays a pivotal role in suppressing anti-tumour immunity via directly r
Externí odkaz:
https://doaj.org/article/07f7321be51a4bf993332239abb08b2b
Autor:
Anne Margriet Heijink, Francien Talens, Lucas T. Jae, Stephanie E. van Gijn, Rudolf S. N. Fehrmann, Thijn R. Brummelkamp, Marcel A. T. M. van Vugt
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The loss of homologous recombination (HR) genes such as BRCA1 and BRCA2 is deleterious to the survival of normal cells, yet it is tolerated in cancer cells. Here the authors identify TNFα signaling as a determinant of viability in BRCA2- inactivated
Externí odkaz:
https://doaj.org/article/fe87c5673305416fa0c30e5631b208ed
Autor:
Pepijn M. Schoonen, Francien Talens, Colin Stok, Ewa Gogola, Anne Margriet Heijink, Peter Bouwman, Floris Foijer, Madalena Tarsounas, Sohvi Blatter, Jos Jonkers, Sven Rottenberg, Marcel A. T. M. van Vugt
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Mutations in BRCA1 and BRCA2 render a cancer cell hypersensitive to PARP inhibitors but they can acquire resistance and relapse. Here the authors find that PARP inhibition leads to replication fork instability, cytokinesis failure and cell death, aid
Externí odkaz:
https://doaj.org/article/86272fb47c1c44e091878a6dfa6f26de
Autor:
Marcel A. T. M. van Vugt, Thijn R. Brummelkamp, Anne Margriet Heijink, Stephanie E van Gijn, Rudolf S N Fehrmann, Francien Talens, Lucas T. Jae
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications, 10(1):100. Nature Publishing Group
Nature Communications
Nature Communications, 10(1):100. Nature Publishing Group
Loss of BRCA2 affects genome stability and is deleterious for cellular survival. Using a genome-wide genetic screen in near-haploid KBM-7 cells, we show that tumor necrosis factor-alpha (TNFα) signaling is a determinant of cell survival upon BRCA2 i
Autor:
Ana Moises Da Silva, Stacey E. P. Joosten, Jinhyuk Bhin, Marcel A. T. M. van Vugt, Maurits Roorda, Wilbert Zwart, Anne Paulien Drenth, Chiara S. Brambillasca, Roebi de Bruijn, Lodewyk F. A. Wessels, Rudolf S N Fehrmann, Catrin Lutz, Linda Henneman, Arkajyoti Bhattacharya, Dario Zimmerli, Eline van der Burg, Jos Jonkers, Max D. Wellenstein, Marieke van de Ven, Karin E. de Visser, Francien Talens, Stefano Annunziato, Mart de Boo, Kelly Kersten
Immune checkpoint inhibitor (ICI) treatment has thus far shown limited efficacy in triple-negative breast cancer (TNBC) patients, presumably due to sparse or unresponsive tumor-infiltrating lymphocytes. We reveal a strong correlation between MYC expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1a3a50f12778f74686f5c57e2768675
https://doi.org/10.1101/2021.02.24.432659
https://doi.org/10.1101/2021.02.24.432659
Autor:
Francien Talens
In order for cells to divide, all the DNA in a cell must be copied and divided into two new cells. However, DNA in our cells is constantly dealing with different types of damage, either from factors outside (eg UV rays in sunlight) or inside the body
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bb6e432abe6b2b792218b0bab36aa22
https://research.rug.nl/en/publications/b00e2986-e8e8-43f1-bd2c-6a913a020671
https://research.rug.nl/en/publications/b00e2986-e8e8-43f1-bd2c-6a913a020671
Autor:
Francien Talens, Colin Stok, Sven Rottenberg, Ewa Gogola, Floris Foijer, Madalena Tarsounas, Marcel A. T. M. van Vugt, Peter Bouwman, Pepijn M Schoonen, Sohvi Blatter, Anne Margriet Heijink, Jos Jonkers
Publikováno v:
Nature Communications
Schoonen, Pepijn M; Talens, Francien; Stok, Colin; Gogola, Ewa; Heijink, Anne Margriet; Bouwman, Peter; Foijer, Floris; Tarsounas, Madalena; Blatter, Sohvi Tuulikki; Jonkers, Jos; Rottenberg, Sven; van Vugt, Marcel A T M (2017). Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells. Nature communications, 8(15981), p. 15981. Nature Publishing Group 10.1038/ncomms15981
Nature Communications, 8:15981. Nature Publishing Group
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Schoonen, Pepijn M; Talens, Francien; Stok, Colin; Gogola, Ewa; Heijink, Anne Margriet; Bouwman, Peter; Foijer, Floris; Tarsounas, Madalena; Blatter, Sohvi Tuulikki; Jonkers, Jos; Rottenberg, Sven; van Vugt, Marcel A T M (2017). Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells. Nature communications, 8(15981), p. 15981. Nature Publishing Group 10.1038/ncomms15981
Nature Communications, 8:15981. Nature Publishing Group
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Mutations in homologous recombination (HR) genes BRCA1 and BRCA2 predispose to tumorigenesis. HR-deficient cancers are hypersensitive to Poly (ADP ribose)-polymerase (PARP) inhibitors, but can acquire resistance and relapse. Mechanistic understanding
Publikováno v:
Expert Opinion on Drug Discovery
Introduction: DNA double-strand breaks (DSBs) are toxic DNA lesions that can be repaired by non-homologous end-joining (NHEJ) or homologous recombination (HR). Mutations in HR genes elicit a predisposition to cancer; yet, they also result in increase
Publikováno v:
Cancer Research. 77:2488-2488
Introduction Breast cancer 2, early onset (BRCA2) is involved in DNA-damage repair via homologous recombination (HR). Defective HR leads to severe genomic instability and homozygous deletion of BRCA2 is therefore deleterious for survival of normal ce
Publikováno v:
Cell Cycle
Recent studies have shown that genomic instability in tumor cells leads to activation of inflammatory signaling through the cGAS/STING pathway. In this review, we describe multiple ways by which genomic instability leads to cGAS/STING-mediated inflam