JAK–STAT signalling shapes the NF‐κB response in CLL towards venetoclax sensitivity or resistance via Bcl‐XL

Autor: Marco V. Haselager, Rachel Thijssen, Danique Bax, Demi Both, Francien De Boer, Simon Mackay, Julie Dubois, Clemens Mellink, Arnon P. Kater, Eric Eldering

Publikováno v: Molecular Oncology, Vol 17, Iss 6, Pp 1112-1128 (2023)

Preventing or overcoming resistance to the Bcl‐2 inhibitor venetoclax is an emerging unmet clinical need in patients with chronic lymphocytic leukaemia (CLL). The upregulation of anti‐apoptotic Bcl‐2 members through signalling pathways within t

Externí odkaz: https://doaj.org/article/2e43009de0ac4b10a008f5313a882ab0

JAK–STAT signalling shapes the NF-κB response in CLL towards venetoclax sensitivity or resistance via Bcl-XL

Autor: Marco V. Haselager, Rachel Thijssen, Danique Bax, Demi Both, Francien De Boer, Simon Mackay, Julie Dubois, Clemens Mellink, Arnon P. Kater, Eric Eldering

Publikováno v: Molecular oncology. Elsevier
Haselager, M V, Thijssen, R, Bax, D, Both, D, de Boer, F, Mackay, S, Dubois, J, Mellink, C, Kater, A P & Eldering, E 2022, ' JAK–STAT signalling shapes the NF-κB response in CLL towards venetoclax sensitivity or resistance via Bcl-XL ', Molecular oncology . https://doi.org/10.1002/1878-0261.13364

Preventing or overcoming resistance to the Bcl-2 inhibitor venetoclax is an emerging unmet clinical need in patients with chronic lymphocytic leukaemia (CLL). The upregulation of anti-apoptotic Bcl-2 members through signalling pathways within the tum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39d35d8654653f5b16a694f07088fe92
https://pure.amc.nl/en/publications/jakstat-signalling-shapes-the-nfb-response-in-cll-towards-venetoclax-sensitivity-or-resistance-via-bclxl(4a996479-0622-45fc-93e2-335ac2000c94).html