Výsledky vyhledávání - "Francielle Tramontini Gomes de Sousa"

Akademický článek

SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-β signaling

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)

Severe COVID-19 is associated with epithelial and endothelial barrier dysfunction, however, the molecular pathways resulting in endothelial barrier dysfunction and vascular leakage are only sparsely understood. Here, Biering et al. show that SARS-CoV

Externí odkaz: https://doaj.org/article/4d267ba8c95f4d14abd51985e3d493fd

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Akademický článek

Flavivirus NS1 Triggers Tissue-Specific Disassembly of Intercellular Junctions Leading to Barrier Dysfunction and Vascular Leak in a GSK-3β-Dependent Manner

Autor: Henry Puerta-Guardo, Scott B. Biering, Francielle Tramontini Gomes de Sousa, Jeffrey Shu, Dustin R. Glasner, Jeffrey Li, Sophie F. Blanc, P. Robert Beatty, Eva Harris

Publikováno v: Pathogens, Vol 11, Iss 6, p 615 (2022)

The flavivirus nonstructural protein 1 (NS1) is secreted from infected cells and contributes to endothelial barrier dysfunction and vascular leak in a tissue-dependent manner. This phenomenon occurs in part via disruption of the endothelial glycocaly

Externí odkaz: https://doaj.org/article/8292051f206346839fc9001624ad368f

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Akademický článek

Intradermal Delivery of Dendritic Cell-Targeting Chimeric mAbs Genetically Fused to Type 2 Dengue Virus Nonstructural Protein 1

Autor: Lennon Ramos Pereira, Elaine Cristina Matos Vicentin, Sara Araujo Pereira, Denicar Lina Nascimento Fabris Maeda, Rúbens Prince dos Santos Alves, Robert Andreata-Santos, Francielle Tramontini Gomes de Sousa, Marcio Massao Yamamoto, Maria Fernanda Castro-Amarante, Marianna Teixeira de Pinho Favaro, Camila Malta Romano, Ester Cerdeira Sabino, Silvia Beatriz Boscardin, Luís Carlos de Souza Ferreira

Publikováno v: Vaccines, Vol 8, Iss 4, p 565 (2020)

Targeting dendritic cells (DCs) by means of monoclonal antibodies (mAbs) capable of binding their surface receptors (DEC205 and DCIR2) has previously been shown to enhance the immunogenicity of genetically fused antigens. This approach has been repea

Externí odkaz: https://doaj.org/article/5571df404a6342e2b65a252d6397abe7

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Akademický článek

Serum from dengue virus-infected patients with and without plasma leakage differentially affects endothelial cells barrier function in vitro.

Autor: Francielle Tramontini Gomes de Sousa Cardozo, Gyulnar Baimukanova, Marion Christine Lanteri, Sheila Marie Keating, Frederico Moraes Ferreira, John Heitman, Cláudio Sérgio Pannuti, Shibani Pati, Camila Malta Romano, Ester Cerdeira Sabino

Publikováno v: PLoS ONE, Vol 12, Iss 6, p e0178820 (2017)

BACKGROUND:Although most of cases of dengue infections are asymptomatic or mild symptomatic some individuals present warning signs progressing to severe dengue in which plasma leakage is a hallmark. METHODOLOGY/PRINCIPAL FINDINGS:The present study us

Externí odkaz: https://doaj.org/article/57a5c36c5dfc4838bafcbfb846e7c499

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Structural basis for antibody inhibition of flavivirus NS1–triggered endothelial dysfunction

Publikováno v: Science (New York, N.Y.), vol 371, iss 6525

Two antibodies against flaviviruses Flaviviruses are a group of RNA viruses that include the human pathogens dengue virus, Zika virus, and West Nile virus. The envelope protein (E) on the virus surface has been the target of vaccine development, but

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ef2b61f780300561fecb6ab2ed38bd1
https://doi.org/10.1126/science.abc0476

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Sulfated β-glucan from Agaricus subrufescens inhibits flavivirus infection and nonstructural protein 1-mediated pathogenesis

Autor: Francielle Tramontini Gomes de Sousa, Scott B. Biering, Trishna S. Patel, Sophie F. Blanc, Carla M. Camelini, Dalila Venzke, Ricardo J. Nunes, Camila M. Romano, P. Robert Beatty, Ester C. Sabino, Eva Harris

Publikováno v: Antiviral Research. 203:105330

Despite substantial morbidity and mortality, no therapeutic agents exist for treatment of dengue or Zika, and the currently available dengue vaccine is only recommended for dengue virus (DENV)-immune individuals. Thus, development of therapeutic and/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82aba4de702813d4b2b603b1f0a4958a
https://doi.org/10.1016/j.antiviral.2022.105330

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Intradermal delivery of dendritic cell-targeting chimeric mAbs genetically fused to type 2 Dengue virus nonstructural protein 1

Autor: Silvia Beatriz Boscardin, Rúbens Prince dos Santos Alves, Ester Cerdeira Sabino, Sara Araujo Pereira, Elaine Cristina Matos Vicentin, Francielle Tramontini Gomes de Sousa, Robert Andreata-Santos, Luís Carlos de Souza Ferreira, Camila Malta Romano, Maria Fernanda de Castro-Amarante, Lennon Ramos Pereira, Marcio Massao Yamamoto, Marianna Teixeira de Pinho Favaro, Denicar Lina Nascimento Fabris Maeda

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Vaccines
Volume 8
Issue 4
Vaccines, Vol 8, Iss 565, p 565 (2020)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec6a8f22d7d93b9a80265c9d3f288c7b

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Anti-Zika virus activity of several abietane-type ferruginol analogues

Autor: Miguel A. González-Cardenete, Camila Malta Romano, Francielle Tramontini Gomes de Sousa, Ester Cerdeira Sabino, Cristina F. Nunes

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
Revista do Instituto de Medicina Tropical de São Paulo, Volume: 62, Article number: e97, Published: 07 DEC 2020
Revista do Instituto de Medicina Tropical de São Paulo, Vol 62 (2020)
Revista do Instituto de Medicina Tropical de São Paulo
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 62 (2020); e97
Revista do Instituto de Medicina Tropical de São Paulo; v. 62 (2020); e97
Instituto de Medicina Tropical (IMT)
instacron:IMT

[EN] Abietane diterpenoids are naturally occurring plant metabolites with a broad spectrum of biological effects including antibacterial. antileishmanial, antitumor, antioxidant, as well as antiinfiammatory activities. Recently, we found that some an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f59642f4b5cfa75370d5e6aa63692f7c
http://hdl.handle.net/10261/253203

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