Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Franciele Martini"'
Publikováno v:
Molecular Biology Reports. 47:2205-2215
Intracerebroventricular streptozotocin injection (icv STZ) is a well established sporadic Alzheimer's disease (AD) model in rodents. AD is characterized by neuronal degeneration accompanied by central oxidative stress. Studies also indicate periphera
Autor:
Mayara Sandrielly Pereira Soares, Wilson Cunico, Daniel Schuch da Silva, Cristina W. Nogueira, João Luis Rheingantz Scaini, Franciele Martini, Bruna da Silveira de Mattos, Anita Avila de Souza, Cesar Emiliano Hoffman da Silva, Karina S. Machado, Ana Paula Pesarico, Roselia Maria Spanevello
Publikováno v:
Neurochemical Research. 45:241-253
This work evaluated the in vitro effect of thiazolidin-4-ones on the activity of AChE (total and isoforms) isolated from the cerebral cortex, hippocampus, and lymphocytes. Kinetic parameters were evaluated and molecular docking was performed. Our res
Autor:
Hecson Jesser, Segat, Franciele, Martini, Karine, Roversi, Suzan Gonçalves, Rosa, Sabrina Grendene, Muller, Domenika Rubert, Rossato, Cristina Wayne, Nogueira, Marilise Escobar, Burger
Publikováno v:
Physiology & Behavior. 251:113804
Amphetamine (AMPH) abuse results in neurobehavioral alterations related to the reward circuit. The hippocampus plays a role in cognition, reward, and drug addiction. There are no pharmacological approaches to prevent AMPH relapse. Physical exercise h
Publikováno v:
Molecular Neurobiology. 55:8991-9000
The present study aimed to investigate the m-trifluoromethyl-diphenyl diselenide [(m-CF3-PhSe)2] effects on prefrontal cortical MOR and KOR protein levels and phenotype induced by repeated forced swim stress (FSS) in mice. Adult Swiss mice were subje
Autor:
Ana Paula Pesarico, Cristina W. Nogueira, Gilson Zeni, César Augusto Brüning, Franciele Martini
Publikováno v:
Journal of Cellular Biochemistry. 119:5598-5608
There is a well-known relationship between the cholinergic system and learning, memory, and other common cognitive processes. The process for researching and developing new drugs has lead researchers to repurpose older ones. This study investigated t
Autor:
Raquel Cristine Silva Barcelos, H.J. Segat, Marilise Escobar Burger, Franciele Martini, Cristina W. Nogueira, César Augusto Brüning
Publikováno v:
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 66:1-7
Amphetamine (AMPH) abuse is a world concern and a serious public health problem. Repeated administration of high doses of AMPH induces neuropsychiatric consequences, including addiction, reward and psychosis, whose pharmacological treatment has shown
Autor:
Sabrina Grendene Müller, Ana Paula Pesarico, Cristina W. Nogueira, Suzan Gonçalves Rosa, Franciele Martini
Publikováno v:
Chemico-Biological Interactions. 317:108959
The isoquinoline 7-fluoro-1,3-diphenylisoquinoline-1-amine (FDPI) has been studied due to its multitarget properties, such as modulation of GABAergic and glutamatergic systems, antioxidant, and anti-inflammatory. This study investigated the contribut
Autor:
Bruna da Cruz Weber Fulco, Francine Luciano Rahmeier, Franciele Martini, Marilda da Cruz Fernandes, Fabiano B. Carvalho, Suzan Gonçalves Rosa, Cristina W. Nogueira, Isabella Pregardier Klann
Publikováno v:
Journal of psychiatric research. 109
Alzheimer 's disease (AD) is characterized by progressive cognitive decline including memory impairment, cortical dysfunction, and neuropsychiatric disturbances. The drug discovery to treat AD consists to develop compounds able to act in multiple mol
Autor:
César Augusto Brüning, Cristina W. Nogueira, Suelen Mendonça Soares, Gilson Zeni, Franciele Martini
Publikováno v:
Scopus-Elsevier
Ebselen is a synthetic organoselenium compound that has been considered a potential pharmacological agent with low toxicity, showing antioxidant, anti-inflammatory and neuroprotective effects. It is bioavailable, blood-brain barrier permeant and safe
Autor:
Cristina W. Nogueira, Gilson Zeni, Suzan Gonçalves Rosa, Tales A. C. Goulart, Franciele Martini, Ana Paula Pesarico
Publikováno v:
Journal of psychiatric research. 94
Certain stressful life events have been associated with the onset of depression. This study aims to investigate if 7-fluoro-1,3-diphenylisoquinoline-1-amine (FDPI) is effective against social avoidance induced by social defeat stress model in mice. F