A scaffold-free approach to cartilage tissue generation using human embryonic stem cells

Autor: Lauren A. Griffith, Katherine M. Arnold, Bram G. Sengers, Rahul S. Tare, Franchesca D. Houghton

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)

Abstract Articular cartilage functions as a shock absorber and facilitates the free movement of joints. Currently, there are no therapeutic drugs that promote the healing of damaged articular cartilage. Limitations associated with the two clinically

Externí odkaz: https://doaj.org/article/b31043f49b7b4effa1cec79d6a35537d

Effect of Oxygen Tension on the Amino Acid Utilisation of Human Embryonic Stem Cells

Autor: David R. Christensen, Philip C. Calder, Franchesca D. Houghton

Publikováno v: Cellular Physiology and Biochemistry, Vol 33, Iss 1, Pp 237-246 (2014)

Background/Aims: Human embryonic stem cells (hESCs) are a potential source of cells for treatment of many degenerative diseases, but in culture have a propensity to spontaneously differentiate, possibly due to suboptimal conditions. Culture at low ox

Externí odkaz: https://doaj.org/article/8a8142aca9634599befcc73636cf9e9a

Incubator type affects human blastocyst formation and embryo metabolism: a randomized controlled trial

Autor: Alexandra J Kermack, Irina Fesenko, David R Christensen, Kate L Parry, Philippa Lowen, Susan J Wellstead, Scott F Harris, Philip C Calder, Nicholas S Macklon, Franchesca D Houghton

Publikováno v: Human reproduction (Oxford, England). 37(12)

STUDY QUESTION Does the type of incubator used to culture human preimplantation embryos affect development to the blastocyst stage and alter amino acid utilization of embryos in assisted reproduction? SUMMARY ANSWER Culturing embryos in a time lapse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78d516ac16e338aa2618b5b4ddd2eab1
https://pubmed.ncbi.nlm.nih.gov/36287638

Maternal intermittent fasting during pregnancy induces fetal growth restriction and down-regulated placental system A amino acid transport in the rat

Autor: Franchesca D. Houghton, Jocelyn D. Glazier, Nick Ashton, Alaa Alkhalefah, Warwick B. Dunn, James W. Allwood, Kate L. Parry

Publikováno v: Alkhalefah, A, Dunn, W, Allwood, J W, Parry, K L, Houghton, F, Ashton, N & Glazier, J 2021, ' Maternal intermittent fasting during pregnancy induces fetal growth restriction and downregulated placental system A amino acid transport in the rat ', Clinical Science . https://doi.org/10.1042/CS20210137

During Ramadan, many pregnant Muslim women fast between dawn and sunset. Although the impacts of prolonged maternal intermittent fasting (IF) on fetal growth and placental function are under-researched, reported effects include reduced placental weig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9298fb3cd9ab58d9d16bf37039aa2f7d
https://pubmed.ncbi.nlm.nih.gov/34467967

Effect of a 6-week 'Mediterranean' dietary intervention on in vitro human embryo development: the Preconception Dietary Supplements in Assisted Reproduction double-blinded randomized controlled trial

Autor: Helena L. Fisk, Susan J. Wellstead, Alexandra J Kermack, Philip C. Calder, Clive Osmond, Nick S. Macklon, Franchesca D. Houghton, Ying Cheong, Philippa Lowen, Markus Montag

Publikováno v: Fertility and sterility. 113(2)

Objective To study the impact of increased dietary intake of omega-3 fatty acids, vitamin D, and olive oil for 6 weeks before in vitro fertilization (IVF) or IVF–intracytoplasmic sperm injection (ICSI) on morphokinetic markers of early embryo devel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87e10e981da7734b957cf7cf835812a1
https://pubmed.ncbi.nlm.nih.gov/31870562