HIF-2α regulates NANOG expression in human embryonic stem cells following hypoxia and reoxygenation through the interaction with an Oct-Sox cis regulatory element.

Autor: Raffaella Petruzzelli, David R Christensen, Kate L Parry, Tilman Sanchez-Elsner, Franchesca D Houghton

Publikováno v: PLoS ONE, Vol 9, Iss 10, p e108309 (2014)

Low O2 tension is beneficial for human embryonic stem cell (hESC) maintenance but the mechanism of regulation is unknown. HIF-2α was found to bind directly to predicted hypoxic response elements (HREs) in the proximal promoter of OCT4, NANOG and SOX

Externí odkaz: https://doaj.org/article/8aac01414f9c45d3a2fb3f181c899cf4

A scaffold-free approach to cartilage tissue generation using human embryonic stem cells

Autor: Katherine M. Arnold, Rahul S. Tare, Lauren A. Griffith, Bram G. Sengers, Franchesca D. Houghton

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports

Articular cartilage functions as a shock absorber and facilitates the free movement of joints. Currently, there are no therapeutic drugs that promote the healing of damaged articular cartilage. Limitations associated with the two clinically relevant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5be9037715284fcb72e1bdf74fb10729
https://doaj.org/article/b31043f49b7b4effa1cec79d6a35537d

Glycolysis Regulates Human Embryonic Stem Cell Self-Renewal under Hypoxia through HIF-2α and the Glycolytic Sensors CTBPs

Autor: Sophie A. Arthur, Jeremy P. Blaydes, Franchesca D. Houghton

Publikováno v: Stem Cell Reports, Vol 12, Iss 4, Pp 728-742 (2019)
Stem Cell Reports

Summary Glycolysis and hypoxia are key regulators of human embryonic stem cell (hESC) self-renewal, but how changes in metabolism affect gene expression is poorly understood. C-terminal binding proteins (CTBPs) are glycolytic sensors that through NAD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b6e1d9e58a5f32355de50edf2fad308
http://www.sciencedirect.com/science/article/pii/S2213671119300530

Maternal intermittent fasting during pregnancy induces fetal growth restriction and down-regulated placental system A amino acid transport in the rat

Autor: Franchesca D. Houghton, Jocelyn D. Glazier, Nick Ashton, Alaa Alkhalefah, Warwick B. Dunn, James W. Allwood, Kate L. Parry

Publikováno v: Alkhalefah, A, Dunn, W, Allwood, J W, Parry, K L, Houghton, F, Ashton, N & Glazier, J 2021, ' Maternal intermittent fasting during pregnancy induces fetal growth restriction and downregulated placental system A amino acid transport in the rat ', Clinical Science . https://doi.org/10.1042/CS20210137

During Ramadan, many pregnant Muslim women fast between dawn and sunset. Although the impacts of prolonged maternal intermittent fasting (IF) on fetal growth and placental function are under-researched, reported effects include reduced placental weig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9298fb3cd9ab58d9d16bf37039aa2f7d
https://pubmed.ncbi.nlm.nih.gov/34467967

Effect of a 6-week 'Mediterranean' dietary intervention on in vitro human embryo development: the Preconception Dietary Supplements in Assisted Reproduction double-blinded randomized controlled trial

Autor: Helena L. Fisk, Susan J. Wellstead, Alexandra J Kermack, Philip C. Calder, Clive Osmond, Nick S. Macklon, Franchesca D. Houghton, Ying Cheong, Philippa Lowen, Markus Montag

Publikováno v: Fertility and sterility. 113(2)

Objective To study the impact of increased dietary intake of omega-3 fatty acids, vitamin D, and olive oil for 6 weeks before in vitro fertilization (IVF) or IVF–intracytoplasmic sperm injection (ICSI) on morphokinetic markers of early embryo devel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87e10e981da7734b957cf7cf835812a1
https://pubmed.ncbi.nlm.nih.gov/31870562