Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Franchesca D Houghton"'
Autor:
Lauren A. Griffith, Katherine M. Arnold, Bram G. Sengers, Rahul S. Tare, Franchesca D. Houghton
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Articular cartilage functions as a shock absorber and facilitates the free movement of joints. Currently, there are no therapeutic drugs that promote the healing of damaged articular cartilage. Limitations associated with the two clinically
Externí odkaz:
https://doaj.org/article/b31043f49b7b4effa1cec79d6a35537d
Publikováno v:
Stem Cell Reports, Vol 12, Iss 4, Pp 728-742 (2019)
Summary: Glycolysis and hypoxia are key regulators of human embryonic stem cell (hESC) self-renewal, but how changes in metabolism affect gene expression is poorly understood. C-terminal binding proteins (CTBPs) are glycolytic sensors that through NA
Externí odkaz:
https://doaj.org/article/f31bb570edb84a878e6a7d2491dc57ca
Autor:
Katherine M. Arnold, Rahul S. Tare, Lauren A. Griffith, Bram G. Sengers, Franchesca D. Houghton
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports
Scientific Reports
Articular cartilage functions as a shock absorber and facilitates the free movement of joints. Currently, there are no therapeutic drugs that promote the healing of damaged articular cartilage. Limitations associated with the two clinically relevant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5be9037715284fcb72e1bdf74fb10729
https://doaj.org/article/b31043f49b7b4effa1cec79d6a35537d
https://doaj.org/article/b31043f49b7b4effa1cec79d6a35537d
Publikováno v:
Cellular Physiology and Biochemistry, Vol 33, Iss 1, Pp 237-246 (2014)
Background/Aims: Human embryonic stem cells (hESCs) are a potential source of cells for treatment of many degenerative diseases, but in culture have a propensity to spontaneously differentiate, possibly due to suboptimal conditions. Culture at low ox
Externí odkaz:
https://doaj.org/article/8a8142aca9634599befcc73636cf9e9a
Autor:
Alexandra J Kermack, Irina Fesenko, David R Christensen, Kate L Parry, Philippa Lowen, Susan J Wellstead, Scott F Harris, Philip C Calder, Nicholas S Macklon, Franchesca D Houghton
Publikováno v:
Human reproduction (Oxford, England). 37(12)
STUDY QUESTION Does the type of incubator used to culture human preimplantation embryos affect development to the blastocyst stage and alter amino acid utilization of embryos in assisted reproduction? SUMMARY ANSWER Culturing embryos in a time lapse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78d516ac16e338aa2618b5b4ddd2eab1
https://pubmed.ncbi.nlm.nih.gov/36287638
https://pubmed.ncbi.nlm.nih.gov/36287638
Autor:
Raffaella Petruzzelli, David R Christensen, Kate L Parry, Tilman Sanchez-Elsner, Franchesca D Houghton
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e108309 (2014)
Low O2 tension is beneficial for human embryonic stem cell (hESC) maintenance but the mechanism of regulation is unknown. HIF-2α was found to bind directly to predicted hypoxic response elements (HREs) in the proximal promoter of OCT4, NANOG and SOX
Externí odkaz:
https://doaj.org/article/8aac01414f9c45d3a2fb3f181c899cf4
Autor:
Nick S. Macklon, Philip C. Calder, Helena L. Fisk, Franchesca D. Houghton, Susan J. Wellstead, Alexandra J Kermack, Ying Cheong
The fatty acid composition of human follicular fluid is important for oocyte development and for pregnancy following in vitro fertilization (IVF). This study investigated whether a dietary intervention that included an increase in marine omega-3 fatt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afd40654e1363620f579b361d02bfdfd
https://eprints.soton.ac.uk/447715/
https://eprints.soton.ac.uk/447715/
Autor:
Franchesca D. Houghton, Jocelyn D. Glazier, Nick Ashton, Alaa Alkhalefah, Warwick B. Dunn, James W. Allwood, Kate L. Parry
Publikováno v:
Alkhalefah, A, Dunn, W, Allwood, J W, Parry, K L, Houghton, F, Ashton, N & Glazier, J 2021, ' Maternal intermittent fasting during pregnancy induces fetal growth restriction and downregulated placental system A amino acid transport in the rat ', Clinical Science . https://doi.org/10.1042/CS20210137
During Ramadan, many pregnant Muslim women fast between dawn and sunset. Although the impacts of prolonged maternal intermittent fasting (IF) on fetal growth and placental function are under-researched, reported effects include reduced placental weig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9298fb3cd9ab58d9d16bf37039aa2f7d
https://pubmed.ncbi.nlm.nih.gov/34467967
https://pubmed.ncbi.nlm.nih.gov/34467967
Autor:
Catherine E Forristal, David R Christensen, Fay E Chinnery, Raffaella Petruzzelli, Kate L Parry, Tilman Sanchez-Elsner, Franchesca D Houghton
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e62507 (2013)
Energy metabolism is intrinsic to cell viability but surprisingly has been little studied in human embryonic stem cells (hESCs). The current study aims to investigate the effect of environmental O2 tension on carbohydrate utilisation of hESCs. Highly
Externí odkaz:
https://doaj.org/article/ba1b8fe218e34a1dbb4e0fee01a9cbbf
Autor:
Franchesca D. Houghton
Publikováno v:
Reproduction (Cambridge, England). 161(1)
Development of the preimplantation embryo is reliant on nutrients present in the milieu of the reproductive tract. While carbohydrates, amino acids, lipids, and micronutrients are often considered when discussing preimplantation embryo nutrition, env
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a1c5031c9d87f50061a9320833e29b9
https://pubmed.ncbi.nlm.nih.gov/33258799
https://pubmed.ncbi.nlm.nih.gov/33258799