Zobrazeno 1 - 10
of 370
pro vyhledávání: '"Francesco Simone"'
Autor:
Alyssa Miller, Sean Chia, Ewa Klimont, Tuomas P. J. Knowles, Michele Vendruscolo, Francesco Simone Ruggeri
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-9 (2024)
Abstract Many proteins self-assemble to form amyloid fibrils, which are highly organized structures stabilized by a characteristic cross-β network of hydrogen bonds. This process underlies a variety of human diseases and can be exploited to develop
Externí odkaz:
https://doaj.org/article/4a28be5ad5b94f218a0a4df7e56e8bbc
Publikováno v:
IEEE Access, Vol 11, Pp 11430-11450 (2023)
The interaction between the physical world and information technologies creates advantages and novel emerging threats. Cyber-physical systems (CPSs) result vulnerable to cyber-related disruptive scenarios, and, for some critical systems, cyber failur
Externí odkaz:
https://doaj.org/article/a285e0cfd64d492ba3863ac5b3875275
Autor:
Stefano Mazza, Nicole Piazza O. Sed, Francesco Simone Conforti, Alberto Fascì, Alessandro Rimondi, Beatrice Marinoni, Valentina Casini, Chiara Ricci, Francesca Munari, Lorena Pirola, Pietro Invernizzi, Carlo Girelli, Guido Lupinacci, Luca Pastorelli, Flaminia Cavallaro, Luca Ferraris, Alice Colucci, Arnaldo Amato, Gian Eugenio Tontini, Maurizio Vecchi, Gionata Fiorino, Flavio Caprioli
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 1, Pp 172-181 (2022)
Abstract Data regarding double switching from originator infliximab (IFX) to IFX biosimilars in inflammatory bowel diseases (IBDs) are lacking. The purpose of this study was to evaluate the safety and efficacy of switching from originator IFX to CT
Externí odkaz:
https://doaj.org/article/e03578acc9754c6fb34334e43c6266ac
Autor:
Matthias M. Schneider, Saurabh Gautam, Therese W. Herling, Ewa Andrzejewska, Georg Krainer, Alyssa M. Miller, Victoria A. Trinkaus, Quentin A. E. Peter, Francesco Simone Ruggeri, Michele Vendruscolo, Andreas Bracher, Christopher M. Dobson, F. Ulrich Hartl, Tuomas P. J. Knowles
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Molecular chaperones from the Hsp70 family can break up protein aggregates, including amyloids. Here, the authors utilize microfluidic diffusional sizing to assess the mechanism of α-synuclein (αS) disaggregation by the Hsc70–DnaJB1–Apg2 system
Externí odkaz:
https://doaj.org/article/9d156d4ff127467f8d1a03fe03aed8f5
Autor:
Ayaka Kamada, Marc Rodriguez-Garcia, Francesco Simone Ruggeri, Yi Shen, Aviad Levin, Tuomas P. J. Knowles
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Green use of plant derived proteins in functional materials has been limited by inefficient methods to control micro and nanoscale structure. Here, the authors use nanoscale assembly of water-insoluble plant proteins to make meter scale films with co
Externí odkaz:
https://doaj.org/article/d8263357e5e94e8cb18eea56171b225d
Autor:
Francesco Simone Ruggeri, Johnny Habchi, Sean Chia, Robert I. Horne, Michele Vendruscolo, Tuomas P. J. Knowles
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Our understanding of the molecular mechanisms underlying pathological protein aggregation remains incomplete. Here, single molecule infrared nanospectroscopy (AFM-IR) offers insight into the structure of Aβ42 oligomeric and fibrillar species and the
Externí odkaz:
https://doaj.org/article/7f8ac1eb0b6149b48b24e7005907776f
Autor:
Francesco Simone Ruggeri, Benedetta Mannini, Roman Schmid, Michele Vendruscolo, Tuomas P. J. Knowles
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
While infrared nanospectroscopy methods based on thermomechanical detection (AFM-IR) enables the acquisition of absorption spectra at the nanoscale, single molecule detection has not been possible so far. Here, the authors present off-resonance, low
Externí odkaz:
https://doaj.org/article/75fd9014aacf4a8eacc2ca3e369c4d03
Autor:
Andrea Costantino, Flavio Caprioli, Luca Elli, Leda Roncoroni, Davide Stocco, Luisa Doneda, Nicoletta Nandi, Francesco Simone Conforti, Daniele Noviello, Roberto Penagini, Maurizio Vecchi
Publikováno v:
Informatics in Medicine Unlocked, Vol 29, Iss , Pp 100867- (2022)
Background: The introduction of telemedicine into gastroenterology practice has been a major change over the past decade. Particularly during the COVID-19 pandemic, it has been very helpful for patients with chronic gastrointestinal disease as it has
Externí odkaz:
https://doaj.org/article/77309da91b11451ab612a8f4afc1a485
Autor:
Jozef Adamcik, Francesco Simone Ruggeri, Joshua T. Berryman, Afang Zhang, Tuomas P. J. Knowles, Raffaele Mezzenga
Publikováno v:
Advanced Science, Vol 8, Iss 2, Pp n/a-n/a (2021)
Abstract Nanomechanical properties of amyloid fibrils and nanocrystals depend on their secondary and quaternary structure, and the geometry of intermolecular hydrogen bonds. Advanced imaging methods based on atomic force microscopy (AFM) have unravel
Externí odkaz:
https://doaj.org/article/d08c5ef0afe6488bb81552dd1465ae27
Autor:
Francesco Simone Mensa, Maurizio Muzzi, Federica Spani, Giuliana Tromba, Christian Dullin, Andrea Di Giulio
Publikováno v:
Applied Sciences, Vol 12, Iss 2, p 769 (2022)
Many techniques are used today to study insect morphology, including light and electron microscopy. Most of them require to specifically prepare the sample, precluding its use for further investigation. In contrast, micro-CT allows a sample to be stu
Externí odkaz:
https://doaj.org/article/2d649ff227ba448bb1be1a151b60265e